Cyclin-dependent kinase inhibitor 2 (KRP2) Recombinant Protein | KRP2 recombinant protein
Recombinant Arabidopsis thaliana Cyclin-dependent kinase inhibitor 2 (KRP2)
NCBI and Uniprot Product Information
NCBI Description
Kip-related protein (KRP) gene, encodes CDK (cyclin-dependent kinase) inhibitor (CKI), negative regulator of cell division. A member of seven KRP genes found in Arabidopsis thaliana. Differential expression patterns for distinct KRPs were revealed by in situ hybridization. Gene was isolated from a yeast two hybrid screen as an interacting protein of CDC2A. Recombinant protein has a strong kinase inhibitor activity in vitro. Transcript is expressed in all tissues examined but is differentially distributed from ICK1. Controls the onset of the endoreduplication cycle through inhibition of CDKA;1. The KRP2 protein abundance is regulated by proteolysis through CDKB1;1 phosphorylation.
Uniprot Description
Binds and inhibits CYCD2-1/CDKA-1 complex kinase activity. Regulates cell division which is crucial for plant growth, development and morphogenesis. May regulate early lateral root initiation by blocking the G1/S phase transition. Controls the mitosis-to-endocycle transition and the onset of the endoreduplication cycle during leaf development through inhibition of mitotic CDKA-1 kinase complexes. Specifically targets CDKA-1.
Research Articles on KRP2
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Product Notes
The KRP2 krp2 (Catalog #AAA1344167) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-209, Full length protein. The amino acid sequence is listed below: MAAVRRRERD VVEENGVTTT TVKRRKMEEE VDLVESRIIL SPCVQATNRG GIVARNSAGA SETSVVIVRR RDSPPVEEQC QIEEEDSSVS CCSTSEEKSK RRIEFVDLEE NNGDDRETET SWIYDDLNKS EESMNMDSSS VAVEDVESRR RLRKSLHETV KEAELEDFFQ VAEKDLRNKL LECSMKYNFD FEKDEPLGGG RYEWVKLNP. It is sometimes possible for the material contained within the vial of "Cyclin-dependent kinase inhibitor 2 (KRP2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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