Smith-Magenis syndrome chromosomal region candidate gene 8-B protein homolog (smcr8b) Recombinant Protein | smcr8b recombinant protein

Recombinant Danio rerio Smith-Magenis syndrome chromosomal region candidate gene 8-B protein homolog (smcr8b), partial

• Gene Names: smcr8b; smcr8
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Smith-Magenis syndrome chromosomal region candidate gene 8-B protein homolog (smcr8b); Recombinant Danio rerio Smith-Magenis syndrome chromosomal region candidate gene 8-B protein homolog (smcr8b); partial; smcr8b recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 985

• Species: Zebrafish
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 47550897
• NCBI GeneID: 407723
• NCBI Accession #: NP_999967.1
• NCBI GenBank Nucleotide #: NM_214802.1
• UniProt Accession #: Q6PUR7
• Molecular Weight: 110,604 Da
• NCBI Official Full Name: guanine nucleotide exchange protein smcr8b
• NCBI Official Synonym Full Names: Smith-Magenis syndrome chromosome region, candidate 8b
• NCBI Official Symbol: smcr8b
• NCBI Official Synonym Symbols: smcr8
• NCBI Protein Information: guanine nucleotide exchange protein smcr8b
• UniProt Protein Name: Guanine nucleotide exchange protein smcr8b
• Protein Family: Smith-Magenis syndrome chromosomal region candidate gene 8-B protein
• UniProt Gene Name: smcr8b
• UniProt Synonym Gene Names: smcr8

Uniprot Description

Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.