Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) Recombinant Protein | TERF2IP recombinant protein

Recombinant Human Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP)

Cat. Num. AAA1300166

• Gene Names: TERF2IP; RAP1; DRIP5
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP); Recombinant Human Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP); TERF2IP recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-399, Full length protein
• Sequence: AEAMDLGKDPNGPTHSSTLFVRDDGSSMSFYVRPSPAKRRLSTLILHGGGTVCRVQEPGAVLLAQPGEALAEASGDFISTQYILDCVERNERLELEAYRLGPASAADTGSEAKPGALAEGAAEPEPQRHAGRIAFTDADDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLRGQEHKYLLGDAPVSPSSQKLKRKAEEDPEAADSGEPQNKRTPDLPEEEYVKEEIQENEEAVKKMLVEATREFEEVVVDESPPDFEIHITMCDDDPPTPEEDSETQPDEEEEEEEEKVSQPEVGAAIKIIRQLMEKFNLDLSTVTQAFLKNSGELEATSAFLASGQRADGYPIWSRQDDIDLQKDDEDTREALVKKFGAQNVARRIEFRKK
• Sequence Length: 398

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 52627149
• NCBI GeneID: 54386
• NCBI Accession #: NP_061848.2
• NCBI GenBank Nucleotide #: NM_018975.3
• UniProt Accession #: Q9NYB0; Q4W4Y2; Q8WYZ3; Q9NWR2; B4DQN4
• Molecular Weight: 44,260 Da
• NCBI Official Full Name: telomeric repeat-binding factor 2-interacting protein 1
• NCBI Official Synonym Full Names: TERF2 interacting protein
• NCBI Official Symbol: TERF2IP
• NCBI Official Synonym Symbols: RAP1; DRIP5
• NCBI Protein Information: telomeric repeat-binding factor 2-interacting protein 1
• UniProt Protein Name: Telomeric repeat-binding factor 2-interacting protein 1
• Protein Family: Telomeric repeat-binding factor 2-interacting protein
• UniProt Gene Name: TERF2IP
• UniProt Synonym Gene Names: DRIP5; RAP1; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; RAP1 homolog; hRap1

NCBI Description

The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010]

Uniprot Description

Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.