Adenylyltransferase and sulfurtransferase MOCS3 (AGAP001737) Recombinant Protein | AGAP001737 recombinant protein
Recombinant Anopheles gambiae Adenylyltransferase and sulfurtransferase MOCS3 (AGAP001737)
NCBI and Uniprot Product Information
Uniprot Description
Plays a central role in 2-thiolation of mcm5S2U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
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Product Notes
The AGAP001737 agap001737 (Catalog #AAA1300025) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-441, full length protein. The amino acid sequence is listed below: MGEMNGEGQI EVLENDIRTL RKQLQEKVQQ LKTLKKHFQK NCITKLNNDE IARYSRQIIL SEIGVQGQLK LKKASVLVVG AGGLGCPAAL YLAGAGIGRI GVLDYDEVEL TNLHRQLLHT EATVGLTKVT SVQSYLEQLN SQIEIETHHA QLTSENALAL LEPYDVVVDA TDNVATRYLL NDACVLLRKP LVSGSALQLE GQLTVYNYRG GPCYRCLFPT PPPPESVTNC GDGGVLGAIT GVIGALQALE TIKIILSNEG VLAGRLLLFD GQQSAFRNLK LRPKKPTCAV CSEAPTLTKL IDYEQFCGMR ATDKDAALTL LEPCERISVR DYHDGWLAAG RDHLLVDVRN ANQYEMCQLP GAPVNVPIED ILSNRRTEEL LARAQQAQLP VYVVCRRGND SQLAVRHLAP LFRERNLPAP RDLIGGLHAW TKTIDPNFPI Y. It is sometimes possible for the material contained within the vial of "Adenylyltransferase and sulfurtransferase MOCS3 (AGAP001737), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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