Triadin (TRDN) Recombinant Protein | TRDN recombinant protein

Recombinant Human Triadin (TRDN), partial

Cat. Num. AAA1293193

• Gene Names: TRDN; TDN; CPVT5; TRISK
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Triadin (TRDN); Recombinant Human Triadin (TRDN); partial; TRDN recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-47
• Sequence: MTEITAEGNA STTTTVIDSK NGSVPKSPGK VLKRTVTEDI VTTFSSP
• Sequence Length: 47

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 365192558
• NCBI GeneID: 10345
• NCBI Accession #: NP_001242949.1
• NCBI GenBank Nucleotide #: NM_001256020.1
• UniProt Accession #: Q13061; Q6NSB8; A5D6W5; F5H2W7
• Molecular Weight: 18,468 Da
• NCBI Official Full Name: triadin isoform 3
• NCBI Official Synonym Full Names: triadin
• NCBI Official Symbol: TRDN
• NCBI Official Synonym Symbols: TDN; CPVT5; TRISK
• NCBI Protein Information: triadin
• UniProt Protein Name: Triadin
• Protein Family: Triadin
• UniProt Gene Name: TRDN

NCBI Description

This gene encodes an integral membrane protein that contains a single transmembrane domain. As similar protein in rabbits plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex in association with the ryanodine receptor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and single nucleotide polymorphisms in this gene may be markers for IgA nephritis. [provided by RefSeq, Oct 2011]

Uniprot Description

Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.