Poliovirus receptor-related protein 3 (PVRL3) Recombinant Protein | PVRL3 recombinant protein

Recombinant Human Poliovirus receptor-related protein 3 (PVRL3), partial

Cat. Num. AAA1287558

• Gene Names: NECTIN3; PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Poliovirus receptor-related protein 3 (PVRL3); Recombinant Human Poliovirus receptor-related protein 3 (PVRL3); partial; PVRL3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 58-404
• Sequence: GPI IVEPHVTAVW GKNVSLKCLI EVNETITQIS WEKIHGKSSQ TVAVHHPQYG FSVQGEYQGR VLFKNYSLND ATITLHNIGF SDSGKYICKA VTFPLGNAQS STTVTVLVEP TVSLIKGPDS LIDGGNETVA AICIAATGKP VAHIDWEGDL GEMESTTTSF PNETATIISQ YKLFPTRFAR GRRITCVVKH PALEKDIRYS FILDIQYAPE VSVTGYDGNW FVGRKGVNLK CNADANPPPF KSVWSRLDGQ WPDGLLASDN TLHFVHPLTF NYSGVYICKV TNSLGQRSDQ KVIYISDPPT TTTLQPTIQW HPSTADIEDL ATEPKKLPFP LSTLATIKDD TIAT
• Sequence Length: 347

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 343168783
• NCBI GeneID: 25945
• NCBI Accession #: NP_001230215.1
• NCBI GenBank Nucleotide #: NM_001243286.1
• UniProt Accession #: Q9NQS3; Q6NVZ3; Q8NC05; Q8WVU4; Q9BVA9; Q9Y412; E9PFR0
• Molecular Weight: 54,375 Da
• NCBI Official Full Name: nectin-3 isoform 2
• NCBI Official Synonym Full Names: nectin cell adhesion molecule 3
• NCBI Official Symbol: NECTIN3
• NCBI Official Synonym Symbols: PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3
• NCBI Protein Information: nectin-3
• UniProt Protein Name: Nectin-3
• UniProt Gene Name: NECTIN3

NCBI Description

This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Description

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.