TNFAIP3 cdna clone
TNFAIP3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
Uniprot Description
TNFAIP3: Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF. Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the interaction requires TAX1BP1. Interacts with TRAF6; the interaction is inhibited by HTLV-1 protein Tax. By TNF. Belongs to the peptidase C64 family.
Protein type: Ubiquitin conjugating system; Apoptosis; Protease; EC 3.4.19.12
Chromosomal Location of Human Ortholog: 6q23
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protease binding; protein binding; protein self-association; ubiquitin binding; ubiquitin-protein ligase activity; ubiquitin-specific protease activity
Biological Process: B-1 B cell homeostasis; inhibition of NF-kappaB transcription factor; negative regulation of B cell activation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of inflammatory response; negative regulation of innate immune response; negative regulation of interferon type I production; negative regulation of interleukin-2 production; negative regulation of interleukin-6 production; negative regulation of protein ubiquitination; negative regulation of smooth muscle cell proliferation; negative regulation of toll-like receptor 3 signaling pathway; negative regulation of tumor necrosis factor production; positive regulation of protein catabolic process; protein deubiquitination; regulation of germinal center formation; regulation of inflammatory response; response to molecule of bacterial origin
Disease: Autoinflammatory Syndrome, Familial, Behcet-like
Research Articles on TNFAIP3
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Product Notes
The TNFAIP3 tnfaip3 (Catalog #AAA1278667) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCTGAAC AAGTCCTTCC TCAGGCTTTG TATTTGAGCA ATATGCGGAA AGCTGTGAAG ATACGGGAGA GAACTCCAGA AGACATTTTT AAACCTACTA ATGGGATCAT TCATCATTTT AAAACCATGC ACCGATACAC ACTGGAAATG TTCAGAACTT GCCAGTTTTG TCCTCAGTTT CGGGAGATCA TCCACAAAGC CCTCATCGAC AGAAACATCC AGGCCACCCT GGAAAGCCAG AAGAAACTCA ACTGGTGTCG AGAAGTCCGG AAGCTTGTGG CGCTGAAAAC GAACGGTGAC GGCAATTGCC TCATGCATGC CACTTCTCAG TACATGTGGG GCGTTCAGGA CACAGACTTG GTACTGAGGA AGGCGCTGTT CAGCACGCTC AAGGAAACAG ACACACGCAA CTTTAAATTC CGCTGGCAAC TGGAGTCTCT CAAATCTCAG GAATTTGTTG AAACGGGGCT TTGCTATGAT ACTCGGAACT GGAATGATGA ATGGGACAAT CTTATCAAAA TGGCTTCCAC AGACACACCC ATGGCCCGAA GTGGACTTCA GTACAACTCA CTGGAAGAAA TACACATATT TGTCCTTTGC AACATCCTCA GAAGGCCAAT CATTGTCATT TCAGACAAAA TGCTAAGAAG TTTGGAATCA GGTTCCAATT TCGCCCCTTT GAAAGTGGGT GGAATTTACT TGCCTCTCCA CTGGCCTGCC CAGGAATGCT ACAGATACCC CATTGTTCTC GGCTATGACA GCCATCATTT TGTACCCTTG GTGACCCTGA AGGACAGTGG GCCTGAAATC CGAGCTGTTC CACTTGTTAA CAGAGACCGG GGAAGATTTG AAGACTTAAA AGTTCACTTT TTGACAGATC CTGAAAATGA GATGAAGGAG AAGCTCTTAA AAGAGTACTT AATGGTGATA GAAATCCCCG TCCAAGGCTG GGACCATGGC ACAACTCATC TCATCAATGC CGCAAAGTTG GATGAAGCTA ACTTACCAAA AGAAATCAAT CTGGTAGATG ATTACTTTGA ACTTGTTCAG CATGAGTACA AGAAATGGCA GGAAAACAGC GAGCAGGGGA GGAGAGAGGG GCACGCCCAG AATCCCATGG AACCTTCCGT GCCCCAGCTT TCTCTCATGG ATGTAAAATG TGAAACGCCC AACTGCCCCT TCTTCATGTC TGTGAACACC CAGCCTTTAT GCCATGAGTG CTCAGAGAGG CGGCAAAAGA ATCAAAACAA ACTCCCAAAG CTGAACTCCA AGCCGGGCCC TGAGGGGCTC CCTGGCATGG CGCTCGGGGC CTCTCGGGGA GAAGCCTATG AGCCCTTGGC GTGGAACCCT GAGGAGTCCA CTGGGGGGCC TCATTCGGCC CCACCGACAG CACCCAGCCC TTTTCTGTTC AGTGAGACCA CTGCCATGAA GTGCAGGAGC CCCGGCTGCC CCTTCACACT GAATGTGCAG CACAACGGAT TTTGTGAACG TTGCCACAAC GCCCGGCAAC TTCACGCCAG CCACGCCCCA GACCACACAA GGCACTTGGA TCCCGGGAAG TGCCAAGCCT GCCTCCAGGA TGTTACCAGG ACATTTAATG GGATCTGCAG TACTTGCTTC AAAAGGACTA CAGCAGAGGC CTCCTCCAGC CTCAGCACCA GCCTCCCTCC TTCCTGTCAC CAGCGTTCCA AGTCAGATCC CTCGCGGCTC GTCCGGAGCC CCTCCCCGCA TTCTTGCCAC AGAGCTGGAA ACGACGCCCC TGCTGGCTGC CTGTCTCAAG CTGCACGGAC TCCTGGGGAC AGGACGGGGA CGAGCAAGTG CAGAAAAGCC GGCTGCGTGT ATTTTGGGAC TCCAGAAAAC AAGGGCTTTT GCACACTGTG TTTCATCGAG TACAGAGAAA ACAAACATTT TGCTGCTGCC TCAGGGAAAG TCAGTCCCAC AGCGTCCAGG TTCCAGAACA CCATTCCGTG CCTGGGGAGG GAATGCGGCA CCCTTGGAAG CACCATGTTT GAAGGATACT GCCAGAAGTG TTTCATTGAA GCTCAGAATC AGAGATTTCA TGAGGCCAAA AGGACAGAAG AGCAACTGAG ATCGAGCCAG CGCAGAGATG TGCCTCGAAC CACACAAAGC ACCTCAAGGC CCAAGTGCGC CCGGGCCTCC TGCAAGAACA TCCTGGCCTG CCGCAGCGAG GAGCTCTGCA TGGAGTGTCA GCATCCCAAC CAGAGGATGG GCCCTGGGGC CCACCGGGGT GAGCCTGCCC CCGAAGACCC CCCCAAGCAG CGTTGCCGGG CCCCCGCCTG TGATCATTTT GGCAATGCCA AGTGCAACGG CTACTGCAAC GAATGCTTTC AGTTCAAGCA GATGTATGGC TAA. It is sometimes possible for the material contained within the vial of "TNFAIP3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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