RTN3 cdna clone
RTN3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]
Uniprot Description
RTN3: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: endomembrane system; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular space; plasma membrane
Molecular Function: protein binding
Biological Process: synaptic transmission
Research Articles on RTN3
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Product Notes
The RTN3 rtn3 (Catalog #AAA1278061) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcggagc cgtcggcggc cactcagtcc cattccatct cctcgtcgtc cttcggagcc gagccgtccg cgcccggcgg cggcgggagc ccaggagcct gccccgccct ggggacgaag agctgcagct cctcctgtgc ggtgcacgat ctgattttct ggagagatgt gaagaagact gggtttgtct ttggcaccac gctgatcatg ctgctttccc tggcagcttt cagtgtcatc agtgtggttt cttacctcat cctggctctt ctctctgtca ccatcagctt caggatctac aagtccgtca tccaagctgt acagaagtca gaagaaggcc atccattcaa agcctacctg gacgtagaca ttactctgtc ctcagaagct ttccataatt acatgaatgc tgccatggtg cacatcaaca gggccctgaa actcattatt cgtctctttc tggtagaaga tctggttgac tccttgaagc tggctgtctt catgtggctg atgacctatg ttggtgctgt ttttaacgga atcacccttc taattcttgc tgaactgctc attttcagtg tcccgattgt ctatgagaag tacaagaccc agattgatca ctatgttggc atcgcccgag atcagaccaa gtcaattgtt gaaaagatcc aagcaaaact ccctggaatc gccaaaaaaa aggcagaata a. It is sometimes possible for the material contained within the vial of "RTN3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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