SATB2 cdna clone
SATB2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]
Uniprot Description
SATB2: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper- layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI). A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis. A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22). Belongs to the CUT homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 2q33
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: protein binding; sequence-specific DNA binding
Biological Process: regulation of transcription from RNA polymerase II promoter
Disease: Glass Syndrome
Research Articles on SATB2
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Product Notes
The SATB2 satb2 (Catalog #AAA1277995) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGAGCGGC GGAGCGAGAG CCCGTGTCTG CGGGACAGCC CCGACCGGCG GAGCGGCAGC CCGGACGTCA AGGGGCCTCC CCCAGTGAAG GTGGCCCGGC TGGAGCAGAA CGGCAGCCCC ATGGGAGCCC GCGGGAGGCC CAACGGCGCC GTGGCCAAGG CCGTGGGAGG TTTGATGATT CCTGTCTTTT GTGTCGTGGA GCAGTTGGAC GGCTCTCTTG AATATGACAA CAGAGAAGAA CACGCCGAGT TTGTCCTGGT GCGGAAAGAT GTGCTTTTTA GCCAGCTGGT GGAGACTGCG CTCCTGGCCC TGGGGTATTC TCACAGCTCT GCGGCCCAGG CCCAAGGAAT AATCAAGCTG GGAAGGTGGA ACCCTCTCCC CCTCAGTTAT GTGACAGATG CACCCGACGC GACAGTGGCC GACATGCTAC AAGATGTCTA TCATGTTGTG ACGTTGAAAA TCCAATTACA AAGTTGTTCA AAGTTGGAAG ACTTGCCTGC GGAGCAGTGG AACCATGCCA CAGTCCGCAA TGCCTTAAAG GAACTGCTCA AAGAGATGAA CCAGAGCACA TTAGCCAAAG AATGCCCTCT CTCCCAGAGT ATGATTTCAT CCATTGTAAA TAGCACATAT TATGCCAATG TGTCAGCAAC CAAGTGCCAG GAGTTTGGGA GATGGTATAA AAAGTACAAG AAGATTAAAG TGGAAAGAGT GGAACGAGAA AACCTTTCAG ACTATTGTGT TCTGGGCCAG CGTCCAATGC ATTTACCAAA TATGAACCAG CTGGCATCCC TGGGGAAAAC CAACGAACAG TCTCCTCACA GCCAAATTCA CCACAGTACT CCAATCCGAA ACCAAGTGCC CGCATTACAG CCCATCATGA GCCCTGGTCT TCTTTCTCCC CAGCTTAGTC CACAACTTGT AAGGCAACAA ATAGCCATGG CCCATCTGAT AAACCAACAG ATTGCCGTTA GCCGGCTCCT GGCTCACCAG CATCCTCAAG CCATCAACCA GCAGTTCCTG AACCATCCAC CCATCCCCAG AGCAGTTAAG CCAGAGCCAA CCAACTCTTC CGTGGAAGTC TCTCCAGATA TCTACCAGCA AGTCAGAGAT GAGCTGAAGA GGGCCAGTGT GTCCCAAGCT GTCTTTGCAA GAGTGGCATT CAACCGCACA CAGGGATTGT TGTCTGAGAT TCTGCGTAAG GAAGAAGACC CTCGGACAGC CTCTCAGTCT CTTCTAGTAA ACCTGAGGGC CATGCAGAAT TTCCTCAATC TGCCAGAAGT GGAGCGAGAT CGCATCTACC AGGATGAGAG GGAGCGGAGC ATGAATCCCA ATGTGAGCAT GGTCTCCTCG GCCTCCAGCA GTCCCAGCTC CTCCCGAACC CCTCAGGCCA AAACCTCGAC ACCGACAACA GACCTCCCTA TTAAGGTGGA CGGCGCCAAC ATCAACATCA CAGCTGCCAT TTATGACGAG ATCCAACAGG AGATGAAAAG GGCCAAGGTG TCTCAAGCCC TGTTTGCCAA AGTGGCTGCA AATAAAAGTC AGGGCTGGCT GTGTGAACTG CTCCGCTGGA AGGAGAACCC AAGCCCAGAA AACCGCACCC TCTGGGAAAA CCTCTGTACC ATCCGTCGCT TCCTGAACCT TCCCCAGCAT GAGAGGGATG TCATCTATGA GGAGGAGTCA AGGCATCACC ACAGCGAACG CATGCAACAC GTGGTCCAGC TTCCCCCTGA GCCGGTGCAG GTACTTCATA GACAGCAGTC TCAGCCAGCC AAGGAGAGTT CCCCTCCCAG AGAAGAAGCG CCTCCCCCAC CTCCTCCGAC TGAAGACAGT TGTGCCAAAA AGCCCCGGTC TCGCACAAAG ATCTCCTTAG AAGCCCTGGG GATCCTCCAA AGCTTTATTC ATGATGTAGG CCTGTACCCA GACCAGGAAG CCATCCACAC TCTTTCGGCT CAGCTGGATC TCCCCAAACA CACCATCATC AAGTTCTTCC AGAACCAGCG GTACCACGTG AAGCACCACG GGAAGCTGAA AGAGCACCTG GGCTCCGCGG TGGACGTGGC TGAATATAAG GACGAGGAGC TGCTGACCGA GTCAGAGGAG AACGACAGCG AGGAAGGCTC CGAGGAGATG TACAAAGTGG AGGCTGAGGA GGAAAATGCT GACAAAAGCA AGGCAGCACC TGCCGAAATT GACCAGAGAT AA. It is sometimes possible for the material contained within the vial of "SATB2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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