HSD17B12 cdna clone
HSD17B12 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011]
Uniprot Description
HSD17B12: Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
Protein type: Membrane protein, integral; Lipid Metabolism - unsaturated fatty acid biosynthesis; EC 1.1.1.62; Oxidoreductase; Lipid Metabolism - androgen and estrogen; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: endoplasmic reticulum membrane
Molecular Function: long-chain-3-hydroxyacyl-CoA dehydrogenase activity; protein binding
Research Articles on HSD17B12
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Product Notes
The HSD17B12 hsd17b12 (Catalog #AAA1277903) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagagcg ctctccccgc cgccggcttc ctgtactggg tcggcgcggg caccgtggcc tacctagccc tgcgtatttc gtactcgctc ttcacggccc tccgggtctg gggagtgggg aatgaggcgg gggtcggccc ggggctcgga gaatgggcag ttgtcacagg tagtactgat ggaattggaa aatcatatgc agaagagtta gcaaagcatg gaatgaaggt tgtccttatc agcagatcaa aggataaact tgaccaggtt tccagtgaaa taagcaatta tacttga. It is sometimes possible for the material contained within the vial of "HSD17B12, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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