HTR2A cdna clone
HTR2A cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Description
5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR
Chromosomal Location of Human Ortholog: 13q14-q21
Cellular Component: plasma membrane
Molecular Function: drug binding; serotonin binding; serotonin receptor activity
Biological Process: cellular calcium ion homeostasis; phosphoinositide 3-kinase cascade; phospholipase C activation; positive regulation of phosphatidylinositol biosynthetic process; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; synaptic transmission
Disease: Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Major Depressive Disorder; Obsessive-compulsive Disorder; Schizophrenia
Research Articles on HTR2A
Similar Products
Product Notes
The HTR2A htr2a (Catalog #AAA1277861) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggatattc tttgtgaaga aaatacttct ttgagctcaa ctacgaactc cctaatgcaa ttaaatgatg acaccaggct ctacagtaat gactttaact ccggagaagc taacacttct gatgcattta actggacagt cgactctgaa aatcgaacca acctttcctg tgaagggtgc ctctcaccgt cgtgtctctc cttacttcat ctccaggaaa aaaactggtc tgctttactg acagccgtag tgattattct aactattgct ggaaacatac tcgtcatcat ggcagtgtcc ctagagaaaa agctgcagaa tgccaccaac tatttcctga tgtcacttgc catagctgat atgctgctgg gtttccttgt catgcccgtg tccatgttaa ccatcctgta tgggtaccgg tggcctctgc cgagcaagct ttgtgcagtc tggatttacc tggacgtgct cttctccacg gcctccatca tgcacctctg cgccatctcg ctggaccgct acgtcgccat ccagaatccc atccaccaca gccgcttcaa ctccagaact aaggcatttc tgaaaatcat tgctgtttgg accatatcag taggtatatc catgccaata ccagtctttg ggctacagga cgattcgaag gtctttaagg aggggagttg cttactcgcc gatgataact ttgtcctgat cggctctttt gtgtcatttt tcattccctt aaccatcatg gtgatcacct actttctaac tatcaagtca ctccagaaag aagctacttt gtgtgtaagt gatcttggca cacgggccaa attagcttct ttcagcttcc tccctcagag ttctttgtct tcagaaaagc tcttccagcg gtcgatccat agggagccag ggtcctacac aggcaggagg actatgcagt ccatcagcaa tgagcaaaag gcatgcaagg tgctgggcat cgtcttcttc ctgtttgtgg tgatgtggtg ccctttcttc atcacaaaca tcatggccgt catctgcaaa gagtcctgca atgaggatgt cattggggcc ctgctcaatg tgtttgtttg gatcggttat ctctcttcag cagtcaaccc actagtctac acactgttca acaagaccta taggtcagcc ttttcacggt atattcagtg tcagtacaag gaaaacaaaa aaccattgca gttaatttta gtgaacacaa taccggcttt ggcctacaag tctagccaac ttcaaatggg acaaaaaaag aattcaaagc aagatgccaa gacaacagat aatgactgct caatggttgc tctaggaaag cagcattctg aagaggcttc taaagacaat agcgacggag tgaatgaaaa ggtgagctgt gtgtga. It is sometimes possible for the material contained within the vial of "HTR2A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
