MTMR14 cdna clone
MTMR14 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with autosomal dominant centronuclear myopathy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 18.[provided by RefSeq, Apr 2010]
Uniprot Description
MTMR14: Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein phosphatase, tyrosine (non-receptor); Phosphatase, lipid; EC 3.1.3.-
Chromosomal Location of Human Ortholog: 3p26
Cellular Component: cytosol; perinuclear region of cytoplasm; ruffle
Molecular Function: phosphatidylinositol-3-phosphatase activity; protein binding; protein serine/threonine phosphatase activity
Biological Process: macroautophagy; phosphatidylinositol biosynthetic process
Disease: Myopathy, Centronuclear, 1
Research Articles on MTMR14
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Product Notes
The MTMR14 mtmr14 (Catalog #AAA1277534) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccggcg ctcgggccgc cgccgccgct gcctcggcgg ggtcctcggc ctcttcaggc aaccagccgc ctcaggagct ggggcttggg gagctgctgg aggagttctc ccggactcag taccgggcca aggatggcag cgggaccggc ggctctaagg ttgagcgcat tgagaagaga tgtctggagc tgtttggccg agactactgt ttcagcgtga ttccaaacac gaatggggat atctgtggcc actatccccg gcacatcgtg ttcctggagt atgagagttc tgagaaggag aaagacacgt ttgagagtac cgtacaggtg agcaagttgc aagacctcat ccaccgcagc aagatggccc ggtgcagagg acggtttgtc tgcccagtaa tcctgttcaa gggcaagcac atttgcaggt cggccacact ggctggatgg ggagagctgt atggacgctc aggctacaac tattttttct cagggggtgc agatgatgcc tgggcagatg tggaggacgt cacggaggag gactgtgctc ttcgaagtgg tgacacgcat ctttttgata aggtcagagg ctatgacatc aagctgcttc gatacctgtc agtcaaatac atctgtgacc tgatggtgga gaacaagaag gtgaagtttg gcatgaatgt aacctcctct gagaaggtgg acaaagccca gcgctatgcc gacttcactc tcctctccat cccgtatcca ggctgtgaat ttttcaagga atataaagat cgggattaca tggcagaagg gctcatattt aactggaagc aggactacgt tgatgcccca ttgagcatcc ccgacttcct gactcactct ctgaacattg actggagcca gtatcagtgt tgggatctgg tgcaacaaac acaaaactac ctgaagctgc tgctttcctt agttaacagt gatgatgaca gcgggctgct ggtacactgt atctcaggct gggatcggac ccccctcttc atctccctcc tgcgcctttc cttgtgggct gatgggctca tccacacgtc cctgaagccc actgagatcc tctacctcac tgtggcctat gactggttcc tcttcgggca catgttggta gatcggctca gcaaagggga ggagattttc ttcttctgct tcaatttttt gaagcatatt acctccgagg agttctctgc tctgaagacc cagaggagga agagtttgcc agcccgggat ggaggcttca ccctggaaga catctgcatg ctgagacgaa aggaccgtgg cagcaccacc agccttggca gcgacttctc cctggtcatg gagagttccc caggagccac tgggagcttc acctatgagg ccgtggagct ggtcccagca ggagcgccaa ctcaggcagc ttggaggaag agccactcat cctctccaca gagtgtcctc tggaaccggc cacaaccctc agaggaccgc ttgccttccc agcaggggct ggcggaagcc aggtcttcca gctcctcttc ctcaaaccat tctgataact ttttcaggat gggtagcagt cccctggagg tccccaaacc caggcttgca gccctgagtg atcgagagac tcggctgcag gaggtgcgct cagccttctt ggctgcgtac agcagcacag tggggcttcg ggcagtagcc cccagtcctt ccggtgccat cgggggcctg ctggagcaat ttgcccgtgg tgttggactc cggagcatca gcagcaatgc cttgtga. It is sometimes possible for the material contained within the vial of "MTMR14, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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