IBTK cdna clone
IBTK cDNA Clone
Gene Names
IBTK; BTKI; BTBD26
Synonyms
IBTK; IBTK cDNA Clone; IBTK cdna clone
Sequence
atgagttcacccatgcctgactgcacatcaaagtgtcgatccctgaagcatgctttggatgtcctttctgtggtaacaaaggggagcgaaaaccagattaaggcctttctctccagtcattgttacaatgctgcaactatcaaggatgtttttggcaggaatgccctccaccttgtttcctcctgtggaaagaaaggagtgttagattggcttattcagaaaggagtggatctgttggtgaaagacaaagagtctggatggacagcattgcacagaagcattttttatggacatattgattgtgtttggtctctattgaagcatggtgttagtctgtatattcaagataaagaaggcttgtcagctttggatcttgtaatgaaggatagaccaactcatgtagtattcaagaatactgatcctacagatgtttatacttggggcgataatacaaattttaccctgggtcatggaagccagaatagcaaacatcatccagagttggtggatctgttctccaggagtgggatttatatcaagcaggtggtgctttgtaaatttcactccgtgtttctgtctcagaaagggcaggtttatacctgtggtcatggtcctggagggcgattaggacatggagatgaacagacatgcttggtccctcggcttgtggaaggactgaatggtcataattgttcccaagtggcagctgctaaggatcatactgttgtattaactgaagatggatgtgtttatacatttggtctaaacatttttcatcaattaggaattattccaccgccttccagttgtaatgtacccagacagatacaggcaaaatatctgaaaggaaggacaatcattggcgttgcagcaggcaggtttcatacagtcctatggactagagaagctgtttacactatgggactaaatggtggacaactgggttgtttgctagatcccaatggagaaaagtgtgtaactgctcctcgtcaggtctctgcccttcaccataaagacattgctctgtctttggttgctgcaagtgatggagctacagtctgtgttaccacaaggggagatatttacttacttgcagactatcagtgcaagaagatggcttctaaacagttgaacttgaaaaaagttcttgtgtctgggggtcatatggaatacaaggttgatcctgaacatttgaaagaaaatgggggtcaaaaaatttgcattcttgcaatggatggagctggaagggtgttttgctggagatcagtcaacagttctctgaagcagtgtcgatgggcctatccacgtcaggtcttcatttctgatattgctttaaatagaaatgaaattctatttgttacgcaagatggagaaggatttagagggagatggtttgaagagaaaagaaagagttctgaaaagaaagagattttatcaaaccttcacaattcctcatcagatgtgtcttatgtctctgatataaatagtgtgtatgaaagaattcgacttgagaaacttacctttgcacatagagctgttagtgtcagcacagatccaagtggatgcaactttgcaatcctgcagtcagatcctaaaacaagcctttatgaaattccagctgtgtcctcatcatccttttttgaagagtttggcaaactgttgagggaagcagatgaaatggacagcattcatgatgtgacatttcaagttggcaatagactcttccctgcacataaatatattttggcagtgcattctgatttttttcagaaattgtttctttcagatggtaatacttcagaatttacagatatttaccagaaagatgaagattctgcagggtgccatctctttgtggtagagaaggttcatcctgacatgtttgaataccttttacaatttatatacacagatacttgtgactttttaactcatggcttcaaaccaagaatacacttaaacaaaaacccagaagaatatcagggaactctgaattctcatttgaataaagtgaatttccatgaagatgataaccagaagtctgcatttgaagtttacaaaagtaatcaagctcaaacagttagtgagaggcagaagagcaaacctaaatcttgtaaaaaaggaaaaaatattagggaagatgatcctgtaagaatgttgcaaactgttgcaaagaaattcgacttcagtaatttgagtagtaggttagatggagtcagatttgaaaatgaaaaaattaatgttattgccaagaacactggtaataaactgaagctaagtcagaaaaaatgttcatttctgtgtgacgtgaccatgaaatcagtggatggaaaggaatttccttgtcataaatgtgttctttgtgctagacttgaatattttcatagtatgctgagtagctcatggattgaggcttccagttgtgcagctctggaaatgccaatacattctgatatattaaaagttattttggactacctctatactgatgaagctgtggtgataaaagaatctcaaaatgtagattttatttgtagtgttcttgtggtggctgatcaacttctcataacccggttgaaagagatttgtgaagtagcattaactgaaaaacttaccctgaagaatgctgctatgctactggaatttgcagcaatgtatagtgcaaaacagttgaaactgtcttgtttacagtttataggattgaatatggcagctttacttgaagcaaggtctcttgatgttttaagcgatggtgttttgaaggatctttctgagttttaccggaaaatgattccagcaatggatagaagagtcattacaccatatcaagatggaccagatattagctatttggaagtagaagatggagatatcttcttgaaagaagaaataaatatggaacaaaatcattcggaaactatgttcaagaaagcaaaaacaaaagctaaaaagaagccacgtaaacgttcagatagttctggaggttataacctttcagatattattcagagtccatcatctacaggattattaaagtctggtaagaccaattctgtggaatctcttccagaactgttgacatcagactctgaaggaagctatgcaggagtgggtagtcctagagatttacagtcccctgatttcacaacaggatttcattcagataagattgaggcgaaagtcaaaccgtatgttaatggtacatctcctgtgtattctagggaagatttaaaaccatgggaaaagtcaccaatacttaaaatatctgctccacagcctattcccagtaacagaattgatactaccagctctgccagttgggttgctggttctttcagtcctgtcagccctcctgttgtggatctcagaactatcatggaaatagaagaaagtagacaaaaatgtggagctacaccaaagtcacatttaggcaaaacagtttctcatggagttaaactttctcagaagcaacgaaaaatgattgcattgactaccaaggaaaacaattcaggaatgaatagcatggaaacagttttattcactccttcaaaagcccccaaaccagtgaatgcatgggcatcttctctgcattcagtttcatccaagtcattccgggatttcttactagaagaaaaaaagtctgttactagccatagttcaggcgatcatgtcaaaaaagtttcttttaaaggaattgaaaattctcaggcaccaaaaattgtcagatgctctacccatggtaccccaggaccagaaggcaaccatatttcagatttaccacttctagacagtcccaatccctggctatcttcttcagtgactgctccatccatggtagccccagtcacttttgcatctattgtagaagaagaactacaacaagaagcagctcttattagaagtcgagaaaaaccgttggctctgattcagattgaggagcatgccatacaagatttattggttttctatgaggcatttggcaaccctgaagagtttgtcattgttgaaaggacaccgcagggaccactggcagtacctatgtggaataagcatggatgctag
Sequence Length
4062
Vector
pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
26,314 Da
NCBI Official Full Name
Homo sapiens inhibitor of Bruton agammaglobulinemia tyrosine kinase, mRNA
NCBI Official Synonym Full Names
inhibitor of Bruton tyrosine kinase
NCBI Official Symbol
IBTK
NCBI Official Synonym Symbols
BTKI; BTBD26
NCBI Protein Information
inhibitor of Bruton tyrosine kinase
UniProt Protein Name
Inhibitor of Bruton tyrosine kinase
Protein Family
UniProt Gene Name
IBTK
UniProt Synonym Gene Names
BTKI; KIAA1417; IBtk
UniProt Entry Name
IBTK_HUMAN
NCBI Description
Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Uniprot Description
IBTK: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 6q14.1
Cellular Component: cytoplasm; nucleoplasm
Molecular Function: protein kinase binding; protein tyrosine kinase inhibitor activity
Biological Process: negative regulation of protein amino acid phosphorylation; release of sequestered calcium ion into cytosol
Research Articles on IBTK
Similar Products
Product Notes
The IBTK ibtk (Catalog #AAA1276751) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgagttcac ccatgcctga ctgcacatca aagtgtcgat ccctgaagca tgctttggat gtcctttctg tggtaacaaa ggggagcgaa aaccagatta aggcctttct ctccagtcat tgttacaatg ctgcaactat caaggatgtt tttggcagga atgccctcca ccttgtttcc tcctgtggaa agaaaggagt gttagattgg cttattcaga aaggagtgga tctgttggtg aaagacaaag agtctggatg gacagcattg cacagaagca ttttttatgg acatattgat tgtgtttggt ctctattgaa gcatggtgtt agtctgtata ttcaagataa agaaggcttg tcagctttgg atcttgtaat gaaggataga ccaactcatg tagtattcaa gaatactgat cctacagatg tttatacttg gggcgataat acaaatttta ccctgggtca tggaagccag aatagcaaac atcatccaga gttggtggat ctgttctcca ggagtgggat ttatatcaag caggtggtgc tttgtaaatt tcactccgtg tttctgtctc agaaagggca ggtttatacc tgtggtcatg gtcctggagg gcgattagga catggagatg aacagacatg cttggtccct cggcttgtgg aaggactgaa tggtcataat tgttcccaag tggcagctgc taaggatcat actgttgtat taactgaaga tggatgtgtt tatacatttg gtctaaacat ttttcatcaa ttaggaatta ttccaccgcc ttccagttgt aatgtaccca gacagataca ggcaaaatat ctgaaaggaa ggacaatcat tggcgttgca gcaggcaggt ttcatacagt cctatggact agagaagctg tttacactat gggactaaat ggtggacaac tgggttgttt gctagatccc aatggagaaa agtgtgtaac tgctcctcgt caggtctctg cccttcacca taaagacatt gctctgtctt tggttgctgc aagtgatgga gctacagtct gtgttaccac aaggggagat atttacttac ttgcagacta tcagtgcaag aagatggctt ctaaacagtt gaacttgaaa aaagttcttg tgtctggggg tcatatggaa tacaaggttg atcctgaaca tttgaaagaa aatgggggtc aaaaaatttg cattcttgca atggatggag ctggaagggt gttttgctgg agatcagtca acagttctct gaagcagtgt cgatgggcct atccacgtca ggtcttcatt tctgatattg ctttaaatag aaatgaaatt ctatttgtta cgcaagatgg agaaggattt agagggagat ggtttgaaga gaaaagaaag agttctgaaa agaaagagat tttatcaaac cttcacaatt cctcatcaga tgtgtcttat gtctctgata taaatagtgt gtatgaaaga attcgacttg agaaacttac ctttgcacat agagctgtta gtgtcagcac agatccaagt ggatgcaact ttgcaatcct gcagtcagat cctaaaacaa gcctttatga aattccagct gtgtcctcat catccttttt tgaagagttt ggcaaactgt tgagggaagc agatgaaatg gacagcattc atgatgtgac atttcaagtt ggcaatagac tcttccctgc acataaatat attttggcag tgcattctga tttttttcag aaattgtttc tttcagatgg taatacttca gaatttacag atatttacca gaaagatgaa gattctgcag ggtgccatct ctttgtggta gagaaggttc atcctgacat gtttgaatac cttttacaat ttatatacac agatacttgt gactttttaa ctcatggctt caaaccaaga atacacttaa acaaaaaccc agaagaatat cagggaactc tgaattctca tttgaataaa gtgaatttcc atgaagatga taaccagaag tctgcatttg aagtttacaa aagtaatcaa gctcaaacag ttagtgagag gcagaagagc aaacctaaat cttgtaaaaa aggaaaaaat attagggaag atgatcctgt aagaatgttg caaactgttg caaagaaatt cgacttcagt aatttgagta gtaggttaga tggagtcaga tttgaaaatg aaaaaattaa tgttattgcc aagaacactg gtaataaact gaagctaagt cagaaaaaat gttcatttct gtgtgacgtg accatgaaat cagtggatgg aaaggaattt ccttgtcata aatgtgttct ttgtgctaga cttgaatatt ttcatagtat gctgagtagc tcatggattg aggcttccag ttgtgcagct ctggaaatgc caatacattc tgatatatta aaagttattt tggactacct ctatactgat gaagctgtgg tgataaaaga atctcaaaat gtagatttta tttgtagtgt tcttgtggtg gctgatcaac ttctcataac ccggttgaaa gagatttgtg aagtagcatt aactgaaaaa cttaccctga agaatgctgc tatgctactg gaatttgcag caatgtatag tgcaaaacag ttgaaactgt cttgtttaca gtttatagga ttgaatatgg cagctttact tgaagcaagg tctcttgatg ttttaagcga tggtgttttg aaggatcttt ctgagtttta ccggaaaatg attccagcaa tggatagaag agtcattaca ccatatcaag atggaccaga tattagctat ttggaagtag aagatggaga tatcttcttg aaagaagaaa taaatatgga acaaaatcat tcggaaacta tgttcaagaa agcaaaaaca aaagctaaaa agaagccacg taaacgttca gatagttctg gaggttataa cctttcagat attattcaga gtccatcatc tacaggatta ttaaagtctg gtaagaccaa ttctgtggaa tctcttccag aactgttgac atcagactct gaaggaagct atgcaggagt gggtagtcct agagatttac agtcccctga tttcacaaca ggatttcatt cagataagat tgaggcgaaa gtcaaaccgt atgttaatgg tacatctcct gtgtattcta gggaagattt aaaaccatgg gaaaagtcac caatacttaa aatatctgct ccacagccta ttcccagtaa cagaattgat actaccagct ctgccagttg ggttgctggt tctttcagtc ctgtcagccc tcctgttgtg gatctcagaa ctatcatgga aatagaagaa agtagacaaa aatgtggagc tacaccaaag tcacatttag gcaaaacagt ttctcatgga gttaaacttt ctcagaagca acgaaaaatg attgcattga ctaccaagga aaacaattca ggaatgaata gcatggaaac agttttattc actccttcaa aagcccccaa accagtgaat gcatgggcat cttctctgca ttcagtttca tccaagtcat tccgggattt cttactagaa gaaaaaaagt ctgttactag ccatagttca ggcgatcatg tcaaaaaagt ttcttttaaa ggaattgaaa attctcaggc accaaaaatt gtcagatgct ctacccatgg taccccagga ccagaaggca accatatttc agatttacca cttctagaca gtcccaatcc ctggctatct tcttcagtga ctgctccatc catggtagcc ccagtcactt ttgcatctat tgtagaagaa gaactacaac aagaagcagc tcttattaga agtcgagaaa aaccgttggc tctgattcag attgaggagc atgccataca agatttattg gttttctatg aggcatttgg caaccctgaa gagtttgtca ttgttgaaag gacaccgcag ggaccactgg cagtacctat gtggaataag catggatgct ag. It is sometimes possible for the material contained within the vial of "IBTK, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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