PSMD1 cdna clone
PSMD1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2010]
Uniprot Description
PSMD1: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Interacts with ADRM1. Belongs to the proteasome subunit S1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: cytosol; membrane; nucleoplasm; nucleus; proteasome complex; proteasome regulatory particle
Molecular Function: endopeptidase activity
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Research Articles on PSMD1
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Product Notes
The PSMD1 psmd1 (Catalog #AAA1275837) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGATCACCT CGGCCGCTGG AATTATTTCT CTTCTGGATG AAGATGAACC ACAGCTTAAG GAATTTGCAC TACACAAATT GAATGCAGTT GTTAATGACT TCTGGGCAGA AATTTCCGAG TCCGTAGACA AAATAGAGGT TTTATACGAA GATGAAGGTT TCCGGAGTCG GCAGTTTGCA GCCTTAGTGG CATCTAAAGT ATTTTATCAC CTGGGGGCTT TTGAGGAGTC TCTGAATTAT GCTCTTGGAG CAGGGGACCT CTTCAATGTC AATGATAACT CTGAATATGT GGAAACTATT ATAGCAAAAT GCATTGATCA CTACACCAAA CAATGTGTGG AAAATGCAGA TTTGCCTGAA GGAGAAAAAA AACCAATTGA CCAGAGATTG GAAGGCATCG TAAATAAAAT GTTCCAGCGA TGTCTAGATG ATCACAAGTA TAAACAGGCT ATTGGCATTG CTCTGGAGAC ACGAAGACTG GACGTCTTTG AAAAGACCAT ACTGGAGTCG AATGATGTCC CAGGAATGTT AGCTTATAGC CTTAAGCTCT GCATGTCTTT AATGCAGAAT AAACAGTTTC GGAATAAAGT ACTAAGAGTT CTAGTTAAAA TCTACATGAA CTTGGAGAAA CCTGATTTCA TCAATGTTTG TCAGTGCTTA ATTTTCTTAG ATGATCCTCA GGCTGTGAGT GATATCTTAG AGAAACTGGT AAAGGAAGAC AACCTCCTGA TGGCATATCA GATTTGTTTT GATTTGTATG AAAGTGCTAG CCAGCAGTTT TTGTCATCTG TAATCCAGAA TCTTCGAACT GTTGGCACCC CTATTGCTTC TGTGCCTGGA TCCACTAATA CGGGTACTGT TCCGGGATCA GAGAAAGACA GTGACTCGAT GGAAACAGAA GAAAAGACAA GCAGTGCATT TGTAGGAAAG ACACCAGAAG CCAGTCCAGA GCCTAAGGAC CAGACTTTGA AAATGATTAA AATTTTAAGT GGTGAAATGG CTATTGAGTT ACATCTGCAG TTCTTAATAC GAAACAATAA TACAGACCTC ATGATTCTAA AAAACACAAA GGATGCAGTA CGGAATTCTG TATGTCATAC TGCAACCGTT ATAGCAAACT CTTTTATGCA CTGTGGGACA ACCAGTGACC AGTTTCTTAG AGATAATTTG GAATGGTTAG CCAGAGCCAC TAACTGGGCA AAATTTACTG CTACAGCCAG TTTGGGTGTA ATTCATAAGG GTCATGAAAA AGAAGCATTA CAGTTAATGG CAACATACCT TCCCAAGGAT ACTTCTCCAG GATCAGCCTA TCAGGAAGGT GGAGGTCTCT ATGCACTAGG TCTTATTCAT GCCAATCATG GTGGTGATAT AATTGACTAT CTGCTTAATC AGCTTAAGAA CGCCAGCAAT GATATCGTTA GACACGGTGG CAGTCTGGGC CTTGGTTTGG CAGCCATGGG AACTGCACGT CAAGATGTTT ATGATTTGCT AAAAACAAAC CTTTATCAGG ATGATGCAGT AACAGGGGAA GCAGCTGGCC TGGCCCTAGG TTTGGTTATG TTGGGCTCTA AAAATGCTCA GGCTATTGAG GACATGGTTG GTTATGCACA AGAAACTCAA CATGAGAAGA TTCTGCGTGG TCTTGCAGTT GGCATAGCTT TAGTAATGTA TGGGAGGATG GAAGAGGCTG ATGCTCTCAT TGAATCTCTC TGTCGTGACA AGGACCCAAT TCTTCGAAGG TCTGGAATGT ATACTGTAGC CATGGCTTAT TGTGGCTCTG GTAACAACAA AGCAATTCGA CGCCTGCTAC ATGTTGCTGT AAGTGATGTT AATGATGATG TCAGGAGGGC AGCAGTAGAA TCACTTGGGT TCATTCTATT CAGAACCCCT GAACAGTGCC CAAGTGTTGT CTCTTTGTTG TCAGAGAGTT ACAACCCTCA TGTGCGCTAC GGAGCTGCAA TGGCCTTGGG GATATGCTGT GCTGGTACAG GAAACAAGGA AGCCATTAAT TTGCTAGAAC CAATGACAAA CGACCCCGTG AACTACGTGA GGCAAGGGGC ACTCATAGCT TCAGCTCTCA TCATGATCCA GCAGACTGAA ATCACTTGTC CAAAGGTGAA TCAGTTCAGA CAGCTGTATT CCAAAGTCAT CAATGATAAG CATGATGATG TCATGGCCAA GTTTGGCGCT ATTCTGGCCC AGGGCATACT GGATGCAGGT GGTCATAATG TCACAATCTC CTTGCAGTCC AGGACTGGGC ATACTCATAT GCCTTCTGTG GTTGGCGTCC TTGTATTTAC CCAGTTTTGG TTCTGGTTTC CTCTTTCACA CTTCCTGTCA TTGGCTTATA CCCCTACCTG TGTCATTGGC CTTAACAAGG ACTTAAAGAT GCCGAAAGTT CAGTATAAAT CGAACTGTAA ACCATCCACA TTTGCATATC CTGCCCCTCT GGAAGTACCA AAAGAAAAAG AAAAGGAAAA GGTTTCTACT GCTGTATTAT CTATAACTGC CAAGGCTAAA AAGAAGGAAA AAGAAAAGGA AAAAAAGGAG GAGGAGAAAA TGGAAGTGGA TGAGGCAGAG AAAAAGGAGG AAAAAGAGAA GAAAAAAGAA CCTGAGCCAA ACTTCCAGTT ATTGGATAAC CCAGCCCGAG TTATGCCTGC CCAGCTTAAG GTCCTAACCA TGCCGGAGAC CTGTAGATAC CAGCCTTTCA AACCACTCTC TATTGGAGGC ATCATCATTC TGAAGGATAC CAGTGAAGAC ATTGAGGAGC TGGTGGAACC TGTGGCAGCA CATGGCCCAA AAATCGAGGA GGAGGAACAA GAGCCAGAAC CCCCAGAACC ATTTGAGTAT ATTGATGATT AA. It is sometimes possible for the material contained within the vial of "PSMD1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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