SETD2 cdna clone
SETD2 cDNA Clone
Gene Names
SETD2; LLS; HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP
Synonyms
SETD2; SETD2 cDNA Clone; SETD2 cdna clone
Sequence
atggaaagaagaggcaagtattcttcaaaactagaaagagaatctaaaaggacttcagaaaatgaagcaattaaaagatgttgttctccccctaatgaactgggattccgacgagggtcatcatattctaagcatgacagtagtgcttcccgttataaatctaccctttcaaaacctatacccaagtctgataaatttaaaaattctttctgttgtacagaattaaatgaagaaatcaaacagtctcattcttttagtttacagacaccttgttcaaaaggtagtgaattaagaatgattaataaaaatcctgaaagagaaaaggctgggtctccagctccatcaaatcgattaaatgattcacctactttaaaaaagctagatgaattgcctatttttaagtccgaatttataacacatgatagccatgatagtattaaggaattagactctttatctaaagtgaagaatgatcaattaagaagtttttgtcccatagaattaaatataaatggatctcctggggcagaatctgatttggcaacattttgcacttctaaaactgatgctgttttaatgacttctgatgatagtgtgactggatcggaattatcccctttggtcaaagcatgcatgctttcatcaaatggatttcagaatattagtaggtgcaaagaaaaagacttggatgatacctgcatgctgcataagaagtcagaaagcccatttagagaaacagaacctctggtgtcaccacaccaagataaactcatgtctatgccagttatgactgtggattattccaaaacagtagttaaagaaccagttgatacgagggtttcttgctgcaaaaccaaagattcagacatatactgtactttgaacgatagcaacccttctttgtgtaactctgaagctgaaaatattgagccttcagttatgaagatttcttcaaatagctttatgaatgtgcatttggaatcaaaaccagttatatgtgatagtagaaatttgacagatcactcaaaatttgcatgtgaagaatataagcagagcatcggtagcactagttcagcttctgttaatcattttgatgatttatatcaacctattgggagttcaggtattgcttcatctcttcagagtcttccaccaggaataaaggtggacagtctaactctcttgaaatgcggagagaacacatctccagttctggatgcagtgctaaagagtaaaaaaagttcagagtttttaaagcatgcagggaaagaaacaatagtagaagtaggtagtgaccttcctgattcaggaaagggatttgcttccagggagaacaggcgtaataatgggttatctgggaaatgtttgcaagaggctcaagaagaagggaattccatattgcctgaaagaagaggaagaccagaaatctctttagatgaaagaggagaaggaggacatgtgcatacttctgatgactcagaagttgtattttcttcttgtgatttgaatttaaccatggaagacagtgatggtgtaacttatgcattaaagtgtgacagtagtggtcatgccccagaaattgtgtctacagttcatgaagattattctggctcttctgaaagttcaaatgatgaaagtgattcagaagatacagattcggatgatagcagtattccaagaaaccgtctccagtctgttgtggttgtgccaaagaattctactttgcccatggaagaaacaagtccttgttcttctcggagcagtcaaagttatagacactattctgaccattgggaagatgagagattggagtcaaggagacatttgtatgaggaaaaatttgaaagtatagcaagtaaagcctgtcctcaaactgataagtttttccttcataaaggaacagagaagaatccggaaatttcttttacacagtccagtagaaaacaaatagataaccgcctgcctgaactttctcatcctcagagtgatggggttgatagtacaagtcatacagatgtgaaatctgaccctctgggtcacccaaattcagaggaaaccgtgaaagccaaaataccttctaggcagcaagaagagctgccaatttattcttctgattttgaagatgtcccaaataagtcttggcaacagaccactttccaaaacaggccagatagtagactgggaaaaacagaattgagtttttcttcctcttgtgagataccacatgtggatggcttgcactcatcagaagagctcagaaacttaggttgggacttctctcaagaaaagccttctaccacgtatcagcaacctgacagtagctatggagcttgtggtggacacaagtatcagcaaaatgcagaacagtatggtgggacacgtgattactggcaaggcaatggttactgggatccaagatcaggtagacctcctggaactggggttgtgtatgatcgaactcaaggacaagtaccagattccctaacagatgatcgtgaagaagaggagaattgggatcaacaggatggatcccatttttcagaccagtccgataaatttcttctatcccttcagaaagacaaggggtcagtgcaagcacctgaaataagcagcaattccattaaggacactttagctgtgaatgaaaagaaagatttttcaaaaaacttagaaaaaaatgatatcaaagatagagggcctcttaaaaaaaggaggcaggaaatagagagtgattctgaaagtgatggtgagcttcaggacagaaagaaagttagagtggaggtagagcagggagagacatcagtgcccccaggttcagcactggttgggccctcctgtgtcatggatgacttcagggacccacagcgatggaaggaatgtgccaagcaagggaaaatgccatgttactttgatcttattgaagaaaatgtttatttaacagaaagaaagaagaataaatctcatcgagatattaagcgaatgcagtgtgagtgtacacctctttctaaagatgaaagagctcaaggtgaaatagcatgtggggaagattgtcttaatcgtcttctcatgattgaatgttcttctcggtgtccaaatggggattattgttccaatagacggtttcagagaaaacagcatgcagatgtggaagtcatactcacagaaaagaaaggctggggcttgagagctgccaaagaccttccttcgaacacctttgtcctagaatattgtggagaggtactcgatcataaagagtttaaagctcgagtgaaggagtatgcacgaaacaaaaacatccattactatttcatggccctgaagaatgatgagataatagatgccactcaaaaaggaaattgctctcgtttcatgaatcacagctgtgaaccaaattgtgaaacccaaaaatggactgtgaacggacaactgagggttgggttttttaccaccaaactggttccttcaggctcagagttaacgtttgactatcagttccagagatatggaaaagaagcccagaaatgtttctgcggatcagccaattgccggggttacctgggaggagaaaacagagtcagcatcagagcagcaggagggaaaatgaagaaggaacgatctcgtaagaaggattcagtggatggagagctagaagctctgatggaaaatggtgagggtctctctgataaaaaccaggtgctcagcttatcccggctaatggttagaattgaaactttggagcagaaacttacctgtctggaactcatacagaacacacactcacagtcctgcctgaagtcctttctggaacgtcatgggctgtctttgttgtggatctggatggcagagctaggtgacggccgggaaagtaaccagaagcttcaggaagagattataaagactttggaacacttgcccattcctactaaaaatatgttggaggaaagcaaagtacttccaattattcaacgctggtctcagactaagactgctgtccctccgttgagtgaaggagatgggtattctagtgagaatacatcgcgtgctcatacaccactcaacacacctgatccttccaccaagctgagcacagaagctgacacagacactcccaagaaactaatgtttcgcagactgaaaattataagtgaaaatagcatggacagtgcaatctctgatgcaaccagtgagctagaaggcaaggatggcaaagaggatcttgatcaattagaaaatgtccctgtagaggaagaggaagaattgcagtcacaacagctactcccacaacagctgcctgaatgcaaagttgatagtgaaaccaacatagaagctagtaagctacctacatctgaaccagaagctgacgctgaaatagagctcaaagagagcaacggcacaaaactagaagaacctattaatgaagaaacaccatcccaagatgaagaggagggtgtgtctgatgtggagagtgaaaggagccaagaacagccagataaaacagtggatataagtgatttggccaccaaactcctggacagttggaaagacctaaaggaggtatatcgaattccaaagaaaagtcaaactgaaaaggaaaacacaacaactgaacgaggaagggatgctgttggcttcagagatcaaacacctgccccgaagactcctaataggtcaagagagagagacccagacaagcaaactcaaaataaagagaaaaggaaacgaagaagctccctctcaccaccctcttctgcctatgagcggggaacaaaaaggccagatgacagatatgatacaccaacttctaaaaagaaagtacgaattaaagaccgcaataaactttctacagaggaacgccggaagttgtttgagcaagaggtggctcaacgggaggctcagaaacaacagcaacagatgcagaacctgggaatgacatcaccactgccctatgactctcttggttataatgccccgcatcatccctttgctggttacccaccaggttatcccatgcaggcctatgtggatcccagcaaccctaatgctggaaaggtgctcctgcccacacccagcatggacccagtgtgttctcctgctccttatgatcatgctcagcccttggtgggacattctacagaacccctttctgcccctccaccagtaccagtggtgccacatgtggcagctcctgtggaagtttccagttcccagtatgtggcccagagtgatggtgtagtacaccaagactccagcgttgctgtcttgccagtgccggcccccggcccagttcagggacagaattatagtgtttgggattcaaaccaacagtctgtcagtgtacagcagcagtactctcctgcacagtctcaagcaaccatatattatcaaggacagacatgtccaacagtctatggtgtgacatcaccttattcacagacaactccaccaattgtacagagttatgcccagccaagtcttcagtatatccaggggcaacagattttcacagctcatccacaaggagtggtggtacagccagccgcagcagtgactacaatagttgcaccagggcagcctcagcccttgcagccatctgaaatggttgtgacaaataatctcttggatctgccgcccccctctcctcccaaaccaaaaaccattgtcttacctcccaactggaagacagctcgagatccagaagggaagatttattactaccatgtgatcacaaggcagactcagtgggatcctcctacttgggaaagcccaggagatgatgccagccttgagcatgaagctgagatggacctgggaactccaacatatgatgaaaaccccatgaaggcctcgaaaaagcccaagacagcagaagcagacacctccagtgaactagcaaagaaaagcaaagaagtattcagaaaagagatgtcccagttcatcgtccagtgcctgaacccttaccggaaacctgactgcaaagtgggaagaattaccacaactgaagactttaaacatctggctcgcaagctgactcacggtgttatgaataaggagctgaagtactgtaagaatcctgaggacctggagtgcaatgagaatgtgaaacacaaaaccaaggagtacattaagaagtacatgcagaagtttggggctgtttacaaacccaaagaggacactgaattagagtga
Sequence Length
6186
Vector
pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
175,982 Da
NCBI Official Full Name
Homo sapiens SET domain containing 2, mRNA
NCBI Official Synonym Full Names
SET domain containing 2
NCBI Official Symbol
SETD2
NCBI Official Synonym Symbols
LLS; HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP
NCBI Protein Information
histone-lysine N-methyltransferase SETD2
UniProt Protein Name
Histone-lysine N-methyltransferase SETD2
Protein Family
UniProt Gene Name
SETD2
UniProt Synonym Gene Names
HIF1; HYPB; KIAA1732; KMT3A; SET2; HIP-1; hSET2
UniProt Entry Name
SETD2_HUMAN
NCBI Description
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
Uniprot Description
SETD2: Histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. Binds DNA at promoters. May also act as a transcription activator that binds to promoters. Binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. Belongs to the histone-lysine methyltransferase family. SET2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine; Amino Acid Metabolism - lysine degradation
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: nucleoplasm
Molecular Function: histone lysine N-methyltransferase activity (H3-K36 specific); histone-lysine N-methyltransferase activity; protein binding
Biological Process: mismatch repair; RNA elongation from RNA polymerase II promoter
Disease: Luscan-lumish Syndrome
Research Articles on SETD2
Similar Products
Product Notes
The SETD2 setd2 (Catalog #AAA1275087) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggaaagaa gaggcaagta ttcttcaaaa ctagaaagag aatctaaaag gacttcagaa aatgaagcaa ttaaaagatg ttgttctccc cctaatgaac tgggattccg acgagggtca tcatattcta agcatgacag tagtgcttcc cgttataaat ctaccctttc aaaacctata cccaagtctg ataaatttaa aaattctttc tgttgtacag aattaaatga agaaatcaaa cagtctcatt cttttagttt acagacacct tgttcaaaag gtagtgaatt aagaatgatt aataaaaatc ctgaaagaga aaaggctggg tctccagctc catcaaatcg attaaatgat tcacctactt taaaaaagct agatgaattg cctattttta agtccgaatt tataacacat gatagccatg atagtattaa ggaattagac tctttatcta aagtgaagaa tgatcaatta agaagttttt gtcccataga attaaatata aatggatctc ctggggcaga atctgatttg gcaacatttt gcacttctaa aactgatgct gttttaatga cttctgatga tagtgtgact ggatcggaat tatccccttt ggtcaaagca tgcatgcttt catcaaatgg atttcagaat attagtaggt gcaaagaaaa agacttggat gatacctgca tgctgcataa gaagtcagaa agcccattta gagaaacaga acctctggtg tcaccacacc aagataaact catgtctatg ccagttatga ctgtggatta ttccaaaaca gtagttaaag aaccagttga tacgagggtt tcttgctgca aaaccaaaga ttcagacata tactgtactt tgaacgatag caacccttct ttgtgtaact ctgaagctga aaatattgag ccttcagtta tgaagatttc ttcaaatagc tttatgaatg tgcatttgga atcaaaacca gttatatgtg atagtagaaa tttgacagat cactcaaaat ttgcatgtga agaatataag cagagcatcg gtagcactag ttcagcttct gttaatcatt ttgatgattt atatcaacct attgggagtt caggtattgc ttcatctctt cagagtcttc caccaggaat aaaggtggac agtctaactc tcttgaaatg cggagagaac acatctccag ttctggatgc agtgctaaag agtaaaaaaa gttcagagtt tttaaagcat gcagggaaag aaacaatagt agaagtaggt agtgaccttc ctgattcagg aaagggattt gcttccaggg agaacaggcg taataatggg ttatctggga aatgtttgca agaggctcaa gaagaaggga attccatatt gcctgaaaga agaggaagac cagaaatctc tttagatgaa agaggagaag gaggacatgt gcatacttct gatgactcag aagttgtatt ttcttcttgt gatttgaatt taaccatgga agacagtgat ggtgtaactt atgcattaaa gtgtgacagt agtggtcatg ccccagaaat tgtgtctaca gttcatgaag attattctgg ctcttctgaa agttcaaatg atgaaagtga ttcagaagat acagattcgg atgatagcag tattccaaga aaccgtctcc agtctgttgt ggttgtgcca aagaattcta ctttgcccat ggaagaaaca agtccttgtt cttctcggag cagtcaaagt tatagacact attctgacca ttgggaagat gagagattgg agtcaaggag acatttgtat gaggaaaaat ttgaaagtat agcaagtaaa gcctgtcctc aaactgataa gtttttcctt cataaaggaa cagagaagaa tccggaaatt tcttttacac agtccagtag aaaacaaata gataaccgcc tgcctgaact ttctcatcct cagagtgatg gggttgatag tacaagtcat acagatgtga aatctgaccc tctgggtcac ccaaattcag aggaaaccgt gaaagccaaa ataccttcta ggcagcaaga agagctgcca atttattctt ctgattttga agatgtccca aataagtctt ggcaacagac cactttccaa aacaggccag atagtagact gggaaaaaca gaattgagtt tttcttcctc ttgtgagata ccacatgtgg atggcttgca ctcatcagaa gagctcagaa acttaggttg ggacttctct caagaaaagc cttctaccac gtatcagcaa cctgacagta gctatggagc ttgtggtgga cacaagtatc agcaaaatgc agaacagtat ggtgggacac gtgattactg gcaaggcaat ggttactggg atccaagatc aggtagacct cctggaactg gggttgtgta tgatcgaact caaggacaag taccagattc cctaacagat gatcgtgaag aagaggagaa ttgggatcaa caggatggat cccatttttc agaccagtcc gataaatttc ttctatccct tcagaaagac aaggggtcag tgcaagcacc tgaaataagc agcaattcca ttaaggacac tttagctgtg aatgaaaaga aagatttttc aaaaaactta gaaaaaaatg atatcaaaga tagagggcct cttaaaaaaa ggaggcagga aatagagagt gattctgaaa gtgatggtga gcttcaggac agaaagaaag ttagagtgga ggtagagcag ggagagacat cagtgccccc aggttcagca ctggttgggc cctcctgtgt catggatgac ttcagggacc cacagcgatg gaaggaatgt gccaagcaag ggaaaatgcc atgttacttt gatcttattg aagaaaatgt ttatttaaca gaaagaaaga agaataaatc tcatcgagat attaagcgaa tgcagtgtga gtgtacacct ctttctaaag atgaaagagc tcaaggtgaa atagcatgtg gggaagattg tcttaatcgt cttctcatga ttgaatgttc ttctcggtgt ccaaatgggg attattgttc caatagacgg tttcagagaa aacagcatgc agatgtggaa gtcatactca cagaaaagaa aggctggggc ttgagagctg ccaaagacct tccttcgaac acctttgtcc tagaatattg tggagaggta ctcgatcata aagagtttaa agctcgagtg aaggagtatg cacgaaacaa aaacatccat tactatttca tggccctgaa gaatgatgag ataatagatg ccactcaaaa aggaaattgc tctcgtttca tgaatcacag ctgtgaacca aattgtgaaa cccaaaaatg gactgtgaac ggacaactga gggttgggtt ttttaccacc aaactggttc cttcaggctc agagttaacg tttgactatc agttccagag atatggaaaa gaagcccaga aatgtttctg cggatcagcc aattgccggg gttacctggg aggagaaaac agagtcagca tcagagcagc aggagggaaa atgaagaagg aacgatctcg taagaaggat tcagtggatg gagagctaga agctctgatg gaaaatggtg agggtctctc tgataaaaac caggtgctca gcttatcccg gctaatggtt agaattgaaa ctttggagca gaaacttacc tgtctggaac tcatacagaa cacacactca cagtcctgcc tgaagtcctt tctggaacgt catgggctgt ctttgttgtg gatctggatg gcagagctag gtgacggccg ggaaagtaac cagaagcttc aggaagagat tataaagact ttggaacact tgcccattcc tactaaaaat atgttggagg aaagcaaagt acttccaatt attcaacgct ggtctcagac taagactgct gtccctccgt tgagtgaagg agatgggtat tctagtgaga atacatcgcg tgctcataca ccactcaaca cacctgatcc ttccaccaag ctgagcacag aagctgacac agacactccc aagaaactaa tgtttcgcag actgaaaatt ataagtgaaa atagcatgga cagtgcaatc tctgatgcaa ccagtgagct agaaggcaag gatggcaaag aggatcttga tcaattagaa aatgtccctg tagaggaaga ggaagaattg cagtcacaac agctactccc acaacagctg cctgaatgca aagttgatag tgaaaccaac atagaagcta gtaagctacc tacatctgaa ccagaagctg acgctgaaat agagctcaaa gagagcaacg gcacaaaact agaagaacct attaatgaag aaacaccatc ccaagatgaa gaggagggtg tgtctgatgt ggagagtgaa aggagccaag aacagccaga taaaacagtg gatataagtg atttggccac caaactcctg gacagttgga aagacctaaa ggaggtatat cgaattccaa agaaaagtca aactgaaaag gaaaacacaa caactgaacg aggaagggat gctgttggct tcagagatca aacacctgcc ccgaagactc ctaataggtc aagagagaga gacccagaca agcaaactca aaataaagag aaaaggaaac gaagaagctc cctctcacca ccctcttctg cctatgagcg gggaacaaaa aggccagatg acagatatga tacaccaact tctaaaaaga aagtacgaat taaagaccgc aataaacttt ctacagagga acgccggaag ttgtttgagc aagaggtggc tcaacgggag gctcagaaac aacagcaaca gatgcagaac ctgggaatga catcaccact gccctatgac tctcttggtt ataatgcccc gcatcatccc tttgctggtt acccaccagg ttatcccatg caggcctatg tggatcccag caaccctaat gctggaaagg tgctcctgcc cacacccagc atggacccag tgtgttctcc tgctccttat gatcatgctc agcccttggt gggacattct acagaacccc tttctgcccc tccaccagta ccagtggtgc cacatgtggc agctcctgtg gaagtttcca gttcccagta tgtggcccag agtgatggtg tagtacacca agactccagc gttgctgtct tgccagtgcc ggcccccggc ccagttcagg gacagaatta tagtgtttgg gattcaaacc aacagtctgt cagtgtacag cagcagtact ctcctgcaca gtctcaagca accatatatt atcaaggaca gacatgtcca acagtctatg gtgtgacatc accttattca cagacaactc caccaattgt acagagttat gcccagccaa gtcttcagta tatccagggg caacagattt tcacagctca tccacaagga gtggtggtac agccagccgc agcagtgact acaatagttg caccagggca gcctcagccc ttgcagccat ctgaaatggt tgtgacaaat aatctcttgg atctgccgcc cccctctcct cccaaaccaa aaaccattgt cttacctccc aactggaaga cagctcgaga tccagaaggg aagatttatt actaccatgt gatcacaagg cagactcagt gggatcctcc tacttgggaa agcccaggag atgatgccag ccttgagcat gaagctgaga tggacctggg aactccaaca tatgatgaaa accccatgaa ggcctcgaaa aagcccaaga cagcagaagc agacacctcc agtgaactag caaagaaaag caaagaagta ttcagaaaag agatgtccca gttcatcgtc cagtgcctga acccttaccg gaaacctgac tgcaaagtgg gaagaattac cacaactgaa gactttaaac atctggctcg caagctgact cacggtgtta tgaataagga gctgaagtac tgtaagaatc ctgaggacct ggagtgcaat gagaatgtga aacacaaaac caaggagtac attaagaagt acatgcagaa gtttggggct gtttacaaac ccaaagagga cactgaatta gagtga. It is sometimes possible for the material contained within the vial of "SETD2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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