TOPBP1 cdna clone
TOPBP1 cDNA Clone
Gene Names
TOPBP1; TOP2BP1
Synonyms
TOPBP1; TOPBP1 cDNA Clone; TOPBP1 cdna clone
Sequence
atgcaccaccagcgatgtgtcccaagagccgaacatccagtttataatatggttatgtctgatgtaaccatatcttgtacaagtctggaaaaagaaaaaagggaagaagttcataaatatgtacaaatgatgggcggacgagtatacagagaccttaatgtatcagtaactcaccttattgcaggagaagttggtagcaaaaaatatttagttgctgcaaacctgaagaaacctattttgcttccctcttggataaaaacactttgggagaagtcacaagagaaaaaaataactagatatactgatataaacatggaagatttcaagtgtcctatttttcttggttgcataatctgtgtgactggcttatgtggcttagacaggaaagaagttcagcaactcacagttaagcatggaggtcaatacatgggacaattgaaaatgaatgaatgtacacacctcattgtgcaagaaccaaaaggtcagaagtatgagtgtgccaagagatggaatgtacactgtgtgaccacacagtggttttttgacagtattgagaaaggtttttgtcaggatgaatccatatacaagacagaacctagaccagaagcaaagactatgcccaattcttcaactcctaccagccagatcaacacaattgatagtcgtactctttcagatgtcagcaatatttccaacataaatgcaagttgcgtaagtgaatcaatatgtaattcacttaacagcaaactggagcctacacttgaaaatctagaaaatctggatgtcagtgcatttcaagcacctgaagatttattagatggttgtcggatatatctttgcggttttagtggcagaaagctagataaactgagaagacttattaacagtggaggtggagttcgttttaaccagctaaatgaagatgtaactcatgttattgtgggagattatgatgatgaattgaagcagttttggaataaatcagcccacaggcctcatgtagtgggagcaaagtggttgctagagtgtttcagtaaaggttatatgctttctgaagaaccatatatccatgctaattaccagccagtggaaattccagtttcacataagcctgaaagtaaagcagctcttttaaaaaagaagaacagcagcttctctaagaaagactttgctcctagtgaaaagcatgagcaagctgatgaagatctgctctctcaatatgaaaatggtagctccacagtagttgaggctaagacgtctgaagccaggccctttaatgattctactcatgctgagcccttgaatgattctactcacatttctttgcaagaagaaaaccagtcttctgtcagtcattgtgtccctgatgtttctacaattactgaagaaggcttatttagccaaaagagtttccttgttttgggttttagtaatgaaaatgaatctaacatcgcaaacatcataaaagaaaatgctgggaaaatcatgtcccttctgagcagaactgttgcggattatgctgtggttcctctgctggggtgtgaagtggaagccactgtgggagaagttgttacaaatacatggctggttacttgcatagactatcagactttgtttgatccaaagtcgaatcctctcttcacaccagttccagtaatgacaggaatgactcctttagaggattgtgttatttcatttagccagtgtgctggagcagaaaaagagtctttaacattcctagcaaacctccttggagcaagtgttcaagaatactttgttcgcaaatccaatgcaaagaaaggcatgtttgccagtactcatcttatactgaaagaacgtggtggctctaaatatgaagctgcaaagaagtggaatttacctgccgttactatagcttggctgttggagactgctagaacgggaaagagagcagacgaaagccattttctgattgaaaattcaactaaagaagaacgaagtttggaaacagaaataacaaatggaatcaatctaaattcagatactgcagagcatcctggcacacgcctgcaaactcacagaaaaaccgtcgttacacctttagatatgaaccgctttcagagtaaagctttccgtgctgtggtctcacaacatgccagacaggtcgcagcctccccagcagtaggacaaccacttcagaaggagccctcgttacacctggatacaccatcaaaattcctgtccaaggacaaactcttcaagccttcctttgatgtgaaggatgcacttgcagccttggaaactccaggacgtcccagccaacagaaaaggaaaccgagtacgccactctcagaagttattgtcaaaaacttgcaacttgctttggcaaatagctctcgaaatgctgtcgctctttctgccagccctcaactgaaagaggcccagtcagagaaggaagaagccccaaagccacttcacaaagtagtggtatgtgttagtaaaaaactcagtaagaagcagagtgaactaaatgggatcgcagcctctctaggagcagattacaggtggagttttgatgaaacagtgactcatttcatctatcaagggcggccaaatgacactaatcgggagtataaatctgtaaaagaaagaggagtacacattgtttccgagcactggcttttagattgtgcccaagagtgtaaacatcttcctgaatctctttatccacatacttataatcccaaaatgagcttggatatcagcgcagtgcaagatggccggctctgtaatagtcgactactctcagctgtgtcttcaacaaaggatgatgagccagatcctttgattttagaagaaaatgatgtagacaatatggccaccaataataaagagtcagcaccatcaaatggaagtggaaagaatgactctaaaggagttctgacacagaccttagagatgagagagaactttcagaagcagttacaggagataatgtctgcaacatcaatagtgaaaccccaagggcagaggacttccctttcaagaagtggttgtaacagcgcatcttcaacccctgacagcactcgctctgctcgcagtggacgaagtagagtcctagaggcactgaggcagtctcgtcagacagtacctgatgtcaacacagagccttcccaaaatgaacagatcatttgggatgaccctacagcaagggaggagagagcaaggcttgccagcaatttgcagtggcctagttgtcccacacaatactctgagcttcaggttgacattcaaaacttggaggattctccttttcaaaagcctttacatgattcagaaattgctaaacaggctgtctgtgatcctggaaacatacgtgtgactgaagctcccaaacacccaatctctgaagaactggaaactcccataaaagacagccacctgatccctacgcctcaagcccccagtattgcctttccactcgccaacccccctgtggctccgcaccctagagaaaagattataacgatagaggagactcatgaagaattaaaaaaacagtacatatttcagttatcatctctgaatcctcaagaacgtattgactattgtcatctgattgagaaactaggtggattggtgatagaaaagcagtgctttgatcccacctgtacacacattgttgtgggacatccacttcgaaacgagaagtatttagcctcagtggcagctgggaagtgggtgcttcatcgctcctaccttgaagcctgcaggactgctggacacttcgtgcaggaagaagactatgaatggggaagtagttccatacttgatgttctgactggaatcaatgtacagcaacgaagactagcacttgcagcaatgagatggagaaaaaaaatccagcaaagacaagaatctggcattgttgagggagcatttagtgggtggaaggttattttacatgtggatcagtctcgagaagcaggcttcaaacgccttcttcagtcaggaggagcaaaggtgctacctggtcattctgtacctttatttaaagaggccacacatcttttttctgacttgaataaactgaaaccagatgactcaggagttaatatagcagaagctgctgcccagaacgtgtactgcttgagaacagaatacattgctgattatctcatgcaggaatcacctcctcatgtagaaaattactgtctaccagaagctatttcatttattcagaataataaggaacttgggactggattatcacaaaagaggaaagctcctacagaaaaaaataaaatcaaacgacctagagtacactaa
Sequence Length
4308
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
170,679 Da
NCBI Official Full Name
Homo sapiens topoisomerase (DNA) II binding protein 1, mRNA
NCBI Official Synonym Full Names
topoisomerase (DNA) II binding protein 1
NCBI Official Symbol
TOPBP1
NCBI Official Synonym Symbols
TOP2BP1
NCBI Protein Information
DNA topoisomerase 2-binding protein 1
UniProt Protein Name
DNA topoisomerase 2-binding protein 1
Protein Family
UniProt Gene Name
TOPBP1
UniProt Synonym Gene Names
KIAA0259; TopBP1
UniProt Entry Name
TOPB1_HUMAN
NCBI Description
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]
Uniprot Description
TOPBP1: a DNA-binding protein and scaffolding protein that is required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR. Contains 7 BRCT domains, which are characteristic of proteins involved in cell cycle checkpoint control in response to DNA damage. Colocalizes with ATR and H2AFX at unsynapsed chromosome cores during prophase. Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Up-regulated during the S phase of the cell cycle. Up-regulated by E2F1 and interferon.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 3q22.1
Cellular Component: actin cytoskeleton; centrosome; chromosome; cytoplasm; Golgi apparatus; nucleoplasm; nucleus; PML body
Molecular Function: identical protein binding; protein binding; protein C-terminus binding
Biological Process: DNA metabolic process; DNA replication; response to DNA damage stimulus; response to ionizing radiation
Research Articles on TOPBP1
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Product Notes
The TOPBP1 topbp1 (Catalog #AAA1274842) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcaccacc agcgatgtgt cccaagagcc gaacatccag tttataatat ggttatgtct gatgtaacca tatcttgtac aagtctggaa aaagaaaaaa gggaagaagt tcataaatat gtacaaatga tgggcggacg agtatacaga gaccttaatg tatcagtaac tcaccttatt gcaggagaag ttggtagcaa aaaatattta gttgctgcaa acctgaagaa acctattttg cttccctctt ggataaaaac actttgggag aagtcacaag agaaaaaaat aactagatat actgatataa acatggaaga tttcaagtgt cctatttttc ttggttgcat aatctgtgtg actggcttat gtggcttaga caggaaagaa gttcagcaac tcacagttaa gcatggaggt caatacatgg gacaattgaa aatgaatgaa tgtacacacc tcattgtgca agaaccaaaa ggtcagaagt atgagtgtgc caagagatgg aatgtacact gtgtgaccac acagtggttt tttgacagta ttgagaaagg tttttgtcag gatgaatcca tatacaagac agaacctaga ccagaagcaa agactatgcc caattcttca actcctacca gccagatcaa cacaattgat agtcgtactc tttcagatgt cagcaatatt tccaacataa atgcaagttg cgtaagtgaa tcaatatgta attcacttaa cagcaaactg gagcctacac ttgaaaatct agaaaatctg gatgtcagtg catttcaagc acctgaagat ttattagatg gttgtcggat atatctttgc ggttttagtg gcagaaagct agataaactg agaagactta ttaacagtgg aggtggagtt cgttttaacc agctaaatga agatgtaact catgttattg tgggagatta tgatgatgaa ttgaagcagt tttggaataa atcagcccac aggcctcatg tagtgggagc aaagtggttg ctagagtgtt tcagtaaagg ttatatgctt tctgaagaac catatatcca tgctaattac cagccagtgg aaattccagt ttcacataag cctgaaagta aagcagctct tttaaaaaag aagaacagca gcttctctaa gaaagacttt gctcctagtg aaaagcatga gcaagctgat gaagatctgc tctctcaata tgaaaatggt agctccacag tagttgaggc taagacgtct gaagccaggc cctttaatga ttctactcat gctgagccct tgaatgattc tactcacatt tctttgcaag aagaaaacca gtcttctgtc agtcattgtg tccctgatgt ttctacaatt actgaagaag gcttatttag ccaaaagagt ttccttgttt tgggttttag taatgaaaat gaatctaaca tcgcaaacat cataaaagaa aatgctggga aaatcatgtc ccttctgagc agaactgttg cggattatgc tgtggttcct ctgctggggt gtgaagtgga agccactgtg ggagaagttg ttacaaatac atggctggtt acttgcatag actatcagac tttgtttgat ccaaagtcga atcctctctt cacaccagtt ccagtaatga caggaatgac tcctttagag gattgtgtta tttcatttag ccagtgtgct ggagcagaaa aagagtcttt aacattccta gcaaacctcc ttggagcaag tgttcaagaa tactttgttc gcaaatccaa tgcaaagaaa ggcatgtttg ccagtactca tcttatactg aaagaacgtg gtggctctaa atatgaagct gcaaagaagt ggaatttacc tgccgttact atagcttggc tgttggagac tgctagaacg ggaaagagag cagacgaaag ccattttctg attgaaaatt caactaaaga agaacgaagt ttggaaacag aaataacaaa tggaatcaat ctaaattcag atactgcaga gcatcctggc acacgcctgc aaactcacag aaaaaccgtc gttacacctt tagatatgaa ccgctttcag agtaaagctt tccgtgctgt ggtctcacaa catgccagac aggtcgcagc ctccccagca gtaggacaac cacttcagaa ggagccctcg ttacacctgg atacaccatc aaaattcctg tccaaggaca aactcttcaa gccttccttt gatgtgaagg atgcacttgc agccttggaa actccaggac gtcccagcca acagaaaagg aaaccgagta cgccactctc agaagttatt gtcaaaaact tgcaacttgc tttggcaaat agctctcgaa atgctgtcgc tctttctgcc agccctcaac tgaaagaggc ccagtcagag aaggaagaag ccccaaagcc acttcacaaa gtagtggtat gtgttagtaa aaaactcagt aagaagcaga gtgaactaaa tgggatcgca gcctctctag gagcagatta caggtggagt tttgatgaaa cagtgactca tttcatctat caagggcggc caaatgacac taatcgggag tataaatctg taaaagaaag aggagtacac attgtttccg agcactggct tttagattgt gcccaagagt gtaaacatct tcctgaatct ctttatccac atacttataa tcccaaaatg agcttggata tcagcgcagt gcaagatggc cggctctgta atagtcgact actctcagct gtgtcttcaa caaaggatga tgagccagat cctttgattt tagaagaaaa tgatgtagac aatatggcca ccaataataa agagtcagca ccatcaaatg gaagtggaaa gaatgactct aaaggagttc tgacacagac cttagagatg agagagaact ttcagaagca gttacaggag ataatgtctg caacatcaat agtgaaaccc caagggcaga ggacttccct ttcaagaagt ggttgtaaca gcgcatcttc aacccctgac agcactcgct ctgctcgcag tggacgaagt agagtcctag aggcactgag gcagtctcgt cagacagtac ctgatgtcaa cacagagcct tcccaaaatg aacagatcat ttgggatgac cctacagcaa gggaggagag agcaaggctt gccagcaatt tgcagtggcc tagttgtccc acacaatact ctgagcttca ggttgacatt caaaacttgg aggattctcc ttttcaaaag cctttacatg attcagaaat tgctaaacag gctgtctgtg atcctggaaa catacgtgtg actgaagctc ccaaacaccc aatctctgaa gaactggaaa ctcccataaa agacagccac ctgatcccta cgcctcaagc ccccagtatt gcctttccac tcgccaaccc ccctgtggct ccgcacccta gagaaaagat tataacgata gaggagactc atgaagaatt aaaaaaacag tacatatttc agttatcatc tctgaatcct caagaacgta ttgactattg tcatctgatt gagaaactag gtggattggt gatagaaaag cagtgctttg atcccacctg tacacacatt gttgtgggac atccacttcg aaacgagaag tatttagcct cagtggcagc tgggaagtgg gtgcttcatc gctcctacct tgaagcctgc aggactgctg gacacttcgt gcaggaagaa gactatgaat ggggaagtag ttccatactt gatgttctga ctggaatcaa tgtacagcaa cgaagactag cacttgcagc aatgagatgg agaaaaaaaa tccagcaaag acaagaatct ggcattgttg agggagcatt tagtgggtgg aaggttattt tacatgtgga tcagtctcga gaagcaggct tcaaacgcct tcttcagtca ggaggagcaa aggtgctacc tggtcattct gtacctttat ttaaagaggc cacacatctt ttttctgact tgaataaact gaaaccagat gactcaggag ttaatatagc agaagctgct gcccagaacg tgtactgctt gagaacagaa tacattgctg attatctcat gcaggaatca cctcctcatg tagaaaatta ctgtctacca gaagctattt catttattca gaataataag gaacttggga ctggattatc acaaaagagg aaagctccta cagaaaaaaa taaaatcaaa cgacctagag tacactaa. It is sometimes possible for the material contained within the vial of "TOPBP1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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