TSHZ3 cdna clone
TSHZ3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016]
Uniprot Description
TSHZ3: Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up- regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. Belongs to the teashirt C2H2-type zinc-finger protein family.
Protein type: Transcription factor; C2H2-type zinc finger protein; DNA-binding
Chromosomal Location of Human Ortholog: 19q12
Cellular Component: nucleoplasm; nucleus
Molecular Function: chromatin binding; protein binding
Biological Process: multicellular organismal development; negative regulation of transcription, DNA-dependent; neurological control of breathing; regulation of transcription from RNA polymerase II promoter
Research Articles on TSHZ3
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Product Notes
The TSHZ3 tshz3 (Catalog #AAA1274697) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCTCCCGG AGCCCAGCCT CTTCAGCACC GTGCAGCTGT ACCGGCAGAG CAGCAAGCTC TATGGCTCCA TCTTCACGGG GGCCAGCAAG TTCCGCTGTA AGGACTGCAG CGCTGCCTAC GACACCCTGG TGGAGTTGAC GGTGCACATG AACGAGACGG GGCATTACCG CGACGACAAC CATGAGACCG ATAACAACAA CCCCAAGCGC TGGTCCAAGC CTCGCAAACG CTCCTTGCTG GAAATGGAAG GGAAGGAAGA CGCCCAGAAG GTGCTGAAGT GCATGTACTG TGGCCACTCC TTTGAGTCCC TGCAGGATTT GAGTGTCCAT ATGATCAAAA CAAAACACTA CCAAAAAGTG CCTCTGAAGG AACCCGTCAC TCCTGTCGCC GCCAAAATCA TCCCTGCCAC TCGGAAGAAA GCTTCCCTGG AGCTGGAGCT CCCCAGCTCC CCAGATTCCA CAGGTGGAAC CCCCAAAGCC ACCATCTCAG ACACCAACGA TGCACTTCAG AAGAACTCCA ACCCTTACAT CACGCCAAAT AATCGGTACG GCCACCAGAA TGGGGCCAGC TATGCATGGC ACTTTGAGGC CCGGAAGTCG CAGATCCTGA AGTGCATGGA GTGTGGGAGC TCGCATGACA CCCTGCAGGA GCTCACTGCC CACATGATGG TCACTGGCCA CTTCATCAAG GTCACCAACT CTGCTATGAA AAAGGGGAAG CCCATTGTGG AGACGCCTGT CACACCTACC ATCACAACCC TGCTGGATGA GAAGGTCCAG TCCGTGCCCC TGGCAGCCAC CACCTTCACG TCCCCCTCCA ATACACCTGC CAGCATCTCC CCAAAACTGA ATGTGGAGGT CAAGAAGGAA GTCGACAAGG AGAAAGCGGT CACTGACGAG AAACCTAAGC AAAAAGACAA GCCTGGCGAA GAAGAGGAGA AGTGTGACAT CTCTTCCAAA TACCATTACT TGACTGAAAA TGACTTAGAA GAGAGTCCCA AGGGGGGGCT TGATATCCTC AAATCCTTGG AAAACACAGT GACATCCGCA ATCAACAAGG CCCAGAACGG CACTCCTAGC TGGGGGGGCT ATCCCAGCAT CCATGCCGCC TACCAACTTC CCAACATGAT GAAGTTGTCC CTGGGCTCGT CGGGGAAGAG CACGCCCCTG AAACCCATGT TTGGCAACAG TGAGATTGTC TCCCCGACGA AAAACCAGAC CCTGGTCTCT CCACCCAGCA GCCAGACGTC CCCCATGCCC AAGACAAACT TTCATGCCAT GGAGGAGCTG GTGAAAAAGG TCACTGAGAA AGTTGCCAAA GTGGAGGAGA AGATGAAGGA GCCGGATGGG AAGCTTTCCC CGCCCAAGCG GGCCACTCCC TCCCCATGTA GCAGCGAAGT CGGGGAACCC ATCAAGATGG AGGCATCCAG CGATGGGGGC TTCCGCAGCC AGGAGAACAG CCCCAGCCCC CCGCGGGATG GGTGCAAGGA TGGGAGCCCC CTCGCTGAGC CGGTGGAGAA TGGCAAGGAG CTGGTGAAGC CCCTAGCCAG CAGTTTGAGT GGCAGCACGG CCATCATCAC CGACCACCCG CCTGAACAGC CTTTTGTTAA CCCTTTGAGC GCCCTGCAGT CAGTCATGAA CATTCACCTG GGCAAGGCCG CCAAGCCCTC CCTGCCTGCC CTGGACCCCA TGAGCATGCT TTTCAAGATG AGCAACAGCC TGGCGGAGAA GGCTGCTGTG GCCACCCCGC CGCCCCTGCA GTCCAAGAAG GCAGACCACC TCGACCGCTA TTTCTACCAC GTCAACAACG ACCAGCCCAT AGACTTGACA AAAGGGAAGA GTGACAAAGG CTGCTCCTTG GGTTCAGTGC TTCTGTCACC CACGTCCACA GCCCCGGCAA CCTCCTCATC CACGGTGACA ACGGCAAAGA CATCTGCCGT CGTATCATTC ATGTCAAACT CGCCGCTACG CGAGAATGCC TTGTCAGATA TATCCGATAT GCTGAAGAAC TTGACAGAGA GCCACACGTC AAAATCCTCC ACTCCTTCCA GCATCTCCGA GAAGTCTGAC ATTGACGGGG CCACTCTGGA GGAGGCTGAG GAGTCGACGC CCGCCCAGAA GAGGAAGGGC CGCCAGTCAA ACTGGAACCC CCAGCACCTC CTGATCCTCC AGGCCCAGTT TGCCGCCAGC CTCCGGCAGA CCTCAGAAGG GAAGTACATC ATGTCAGACC TGAGCCCCCA GGAGCGGATG CATATCTCCA GGTTCACCGG GCTGTCCATG ACCACCATCA GCCACTGGCT GGCCAACGTG AAATACCAGC TTCGAAGGAC AGGTGGAACA AAGTTCCTCA AAAACTTGGA CACTGGCCAC CCCGTCTTCT TTTGTAACGA TTGTGCGTCC CAAATCAGGA CTCCTTCCAC GTACATCAGT CACCTAGAGT CACACTTAGG CTTCCGGCTA CGGGACTTAT CCAAACTGTC CACCGAACAG ATTAACAGTC AGATAGCACA AACCAAGTCA CCGTCAGAAA AAATGGTGAC GTCCTCCCCC GAGGAAGACC TGGGGACTTC CTATCAGTGC AAACTTTGCA ATCGGACCTT TGCCAGCAAG CACGCTGTTA AACTTCACCT TAGCAAAACA CACGGGAAAT CTCCGGAAGA CCACCTTCTG TATGTCTCTG AGTTAGAGAA GCAGTAG. It is sometimes possible for the material contained within the vial of "TSHZ3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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