USP36 cdna clone
USP36 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]
Uniprot Description
USP36: May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Belongs to the peptidase C19 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus; Ubiquitin-specific protease; EC 3.4.19.12; Protease; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: nucleolus; nucleus
Molecular Function: ubiquitin-specific protease activity
Biological Process: protein deubiquitination
Research Articles on USP36
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Product Notes
The USP36 usp36 (Catalog #AAA1274413) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgccaatag tggataagtt gaaggaggcc ctgaaacccg gccgcaagga ctcggctgat gatggagaac tggggaagct tcttgcctcc tctgccaaga aggtcctttt acagaaaatc gagttcgagc cagccagcaa gagcttctcc taccagctgg aggccttaaa gagcaaatat gtgttgctca accccaaaac agagggagct agtcgccaca agagtggaga tgacccaccg gccaggagac agggcagtga gcacacgtat gagagctgtg gtgacggagt cccagccccg cagaaagtgc ttttccccac ggagcgactg tctctgaggt gggagcgggt cttccgcgtg ggcgcaggac tccacaacct tggcaacacc tgctttctca atgccaccat ccagtgcttg acctacacac cacctctagc caactacctg ctctccaagg agcatgctcg cagctgccac cagggaagct tctgcatgct gtgtgtcatg cagaaccaca ttgtccaggc cttcgccaac agcggcaacg ccatcaagcc cgtctccttc atccgagacc tgaaaaagat cgcccgacac ttccgctttg ggaaccagga ggacgcgcat gagttcctgc ggtacaccat cgacgccatg cagaaagcct gcctgaatgg ctgtgccaag tgcgtgcttc cccacccacc ctcccagggc tttggacacc ttttctacat ggtggcagca gaacattcct atggcaacag ccagcccggc acctttctac ccaggctgcc cttgggtaga cgtggcagaa tttgcctctg ggtactcaaa ctgttggagc ccaaatag. It is sometimes possible for the material contained within the vial of "USP36, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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