GTPBP3 cdna clone

GTPBP3 cDNA Clone

Cat. Num. AAA1273932

• Gene Names: GTPBP3; MSS1; MTGP1; THDF1; GTPBG3; COXPD23
• Synonyms: GTPBP3; GTPBP3 cDNA Clone; GTPBP3 cdna clone

• Sequence: atgtggcgggggctttggaccctggcggcccaagcggcacgtgggcctcgcagattgtgcacgcgccggagcagcggcgcaccagcccccggctccggcgccaccatcttcgcgctaagctctggccaaggccgctgcggcatcgcagtgatccggaccagcggccccgccagcggccacgccctccgaattctcacagcaccccgagacctgccccttgctcgccacgccagcctgcgcctgctcagcgatccccgctccggggagcctctggaccgcgcactggtgctctggttcccaggtccccagagtttcaccggtgaggactgcgtggagttccacgtgcatggaggcccggcagtggtgagcggcgtcctgcaggccttgggcagcgtgccagggcttcgaccggcggaggcaggcgagttcaccagacgggcgttcgccaatgggaagctgaacctgaccgaagtggaggggctggcggaccttatccacgcggaaacagaggcgcagcggcggcaggccctcaggcagctggacggagagctgggccacctctgccgtggctgggccgagaccctcaccaaagctctggcccacgtggaggcctatatcgatttcggcgaggatgacaacctggaggagggggtcctggagcaagccgacatcgaagtacgggcactgcaggtggccctgggtgcacatctacgagatgccaggcgcgggcagaggctccgctcaggggtgcacgtagtggtcactggaccccccaatgcgggcaagagcagcctagtgaacctgctcagtcggaagcctgtgtccatcgtgtccccggagccagggaccacccgtgacgtgctggagaccccagtcgacctggccggatttcctgtgctgctgagcgacacggctgggttgcgggagggcgtggggcccgtggagcaggagggcgtgcggcgcgcccgggagaggctagagcaggctgacctcattctggccatgctggatgcttctgacctggcctctccctccagttgcaacttcctggccaccgtcgtagcctctgtgggagcccagagccccagtgacagcagccagcacctcctcctggtgctgaacaagtcggacctgctgtccccggagggcccaggtcccggtcctgacctgcccccgcacctgctgctgtcctgtctgacgggagaggggctggacggcctcctggaggcgctgaggaaggagctagctgcagtgtgtggggacccgtccacagatcccccgctgctgacccgagcaaggcaccagcaccacctccagggttgcctggatgccctcggccactacaagcagtcaaaagacctggccctggcggcagaggcgctgcgggtggcccggggtcacctgacccggctcacaggtggagggggtaccgaggagatcctggacatcatcttccaggacttctgtgtgggcaagtga
• Sequence Length: 1479

• Vector: Please Inquire

NCBI and Uniprot Product Information

• NCBI GI #: 17939530
• NCBI GeneID: 84705
• Molecular Weight: 54,440 Da
• NCBI Official Full Name: Homo sapiens GTP binding protein 3 (mitochondrial), mRNA
• NCBI Official Synonym Full Names: GTP binding protein 3 (mitochondrial)
• NCBI Official Symbol: GTPBP3
• NCBI Official Synonym Symbols: MSS1; MTGP1; THDF1; GTPBG3; COXPD23
• NCBI Protein Information: tRNA modification GTPase GTPBP3, mitochondrial
• UniProt Protein Name: tRNA modification GTPase GTPBP3, mitochondrial
• Protein Family: tRNA modification GTPase
• UniProt Gene Name: GTPBP3
• UniProt Synonym Gene Names: MTGP1
• UniProt Entry Name: GTPB3_HUMAN

NCBI Description

This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2010]

Uniprot Description

GTPBP3: GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs (Probable). Belongs to the Era/MnmE GTP-binding protein family. MnmE subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: mitochondrion

Molecular Function: GTP binding; GTPase activity; protein binding

Biological Process: tRNA methylation; tRNA wobble uridine modification

Disease: Combined Oxidative Phosphorylation Deficiency 23