IRAK2 cdna clone
IRAK2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]
Uniprot Description
IRAK2: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; IRAK family
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: cytoplasm; cytosol; endosome membrane; nucleus; plasma membrane
Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity; protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; inhibition of NF-kappaB transcription factor; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; protein amino acid phosphorylation; regulation of cytokine and chemokine mediated signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
Research Articles on IRAK2
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Product Notes
The IRAK2 irak2 (Catalog #AAA1273781) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCCTGCT ACATCTACCA GCTGCCCTCC TGGGTGCTGG ACGACCTGTG CCGCAACATG GACGCGCTCA GCGAGTGGGA CTGGATGGAG TTCGCCTCCT ACGTGATCAC AGACCTGACC CAGCTGCGGA AGATCAAGTC CATGGAGCGG GTGCAGGGTG TGAGCATCAC GCGGGAGCTG CTGTGGTGGT GGGGCATGCG GCAGGCCACC GTCCAGCAAC TTGTGGACCT CCTGTGCCGC CTGGAGCTCT ACCGGGCTGC CCAGATCATC CTGAACTGGA AACCGGCTCC TGAAATCAGG TGTCCCATTC CAGCCTTCCC TGACTCTGTG AAGCCAGAAA AGCCTTTGGC AGCTTCTGTA AGAAAGGCTG AGGATGAACA GGAAGAGGGG CAGCCTGTGA GGATGGCCAC CTTTCCAGGC CCAGGGTCCT CTCCAGCCAG AGCCCACCAG CCGGCCTTTC TCCAGCCTCC TGAAGAAGAT GCCCCTCATT CCTTGAGAAG CGACCTCCCC ACTTCGTCTG ATTCAAAGGA CTTCAGCACC TCCATTCCTA AGCAGGAAAA ACTTTTGAGC TTGGCTGGAG ACAGCCTTTT CTGGAGTGAG GCAGACGTGG TCCAGGCAAC CGATGACTTC AATCAAAACC GCAAAATCAG CCAGGGGACC TTTGCTGACG TCTACAGAGG GCACAGGCAC GGGAAGCCAT TCGTCTTCAA GAAGCTCAGA GAGACAGCCT GTTCAAGTCC AGGATCAATC GAAAGATTCT TCCAGGCAGA GTTGCAGATT TGTCTTAGAT GCTGCCACCC CAATGTCTTA CCTGTGCTGG GCTTCTGTGC TGCAAGACAG TTTCACAGCT TCATCTACCC CTACATGGCA AATGGTTCCC TACAGGACAG ACTGCAGGGT CAGGGTGGCT CGGACCCCCT CCCCTGGCCC CAGCGTGTCA GCATCTGCTC AGGGCTGCTC TGTGCCGTCG AGTACCTGCA TGGTCTGGAG ATCATCCACA GCAACGTCAA GAGCTCTAAT GTCTTGCTGG ACCAAAATCT CACCCCCAAA CTTGCTCACC CAATGGCTCA TCTGTGTCCT GTCAACAAAA GGTCAAAATA CACCATGATG AAGACTCACC TGCTCCGGAC GTCAGCCGCG TATCTGCCAG AGGATTTCAT CCGGGTGGGG CAGCTGACAA AGCGAGTGGA CATCTTCAGC TGTGGAATAG TGTTGGCCGA GGTCCTCACG GGCATCCCTG CAATGGATAA CAACCGAAGC CCGGTTTACC TGAAGGACTT ACTCCTCAGT GATATTCCAA GCAGCACCGC CTCGCTCTGC TCCAGGAAGA CGGGCGTGGA GAACGTGATG GCAAAGGAGA TCTGCCAGAA GTACCTGGAG AAGGGCGCAG GGAGGCTTCC GGAGGACTGC GCCGAGGCCC TGGCCACGGC TGCCTGCCTG TGCCTGCGGA GGCGTAACAC CAGCCTGCAG GAGGTGTGTG GCTCTGTGGC TGCTGTGGAA GAGCGGCTCC GAGGTCGGGA GACGTTGCTC CCTTGGAGTG GGCTTTCTGA GGGTACAGGC TCTTCTTCCA ACACCCCAGA GGAAACAGAC GACGTTGACA ATTCCAGCCT TGATGCCTCC TCCTCCATGA GTGTGGCACC CTGGGCAGGG GCTGCCACCC CACTTCTCCC CACAGAGAAT GGGGAAGGAA GGCTGCGGGT CATCGTGGGA AGGGAGGCTG ACTCCTCCTC TGAGGCCTGT GTTGGCCTGG AGCCTCCCCA GGATGTTACA GAAACTTCGT GGCAAATTGA GATCAATGAG GCCAAAAGGA AACTGATGGA GAATATTCTG CTCTACAAAG AGGAAAAAGT GGACAGCATT GAGCTCTTTG GCCCCTGA. It is sometimes possible for the material contained within the vial of "IRAK2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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