AHCY cdna clone
AHCY cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Uniprot Description
SAHH: Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Defects in AHCY are the cause of hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD). A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy. Belongs to the adenosylhomocysteinase family.
Protein type: Amino Acid Metabolism - cysteine and methionine; Hydrolase; EC 3.3.1.1; Other Amino Acids Metabolism - selenoamino acid
Chromosomal Location of Human Ortholog: 20q11.22
Cellular Component: cytoplasm; cytosol
Molecular Function: adenosylhomocysteinase activity; protein binding
Biological Process: methylation; S-adenosylmethionine cycle; sulfur amino acid metabolic process
Disease: Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency
Research Articles on AHCY
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Product Notes
The AHCY ahcy (Catalog #AAA1273471) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtctgaca aactgcccta caaagtcgcc gacatcggcc tggctgcctg gggacgcaag gccctggaca ttgctgagaa cgagatgccg ggcctgatgc gtatgcggga gcggtactcg gcctccaagc cactgaaggg cgcccgcatc gctggctgcc tgcacatgac cgtggagacg gccgtcctca ttgagaccct cgtcaccctg ggtgctgagg tgcagtggtc cagctgcaac atcttctcca cccaggacca tgcggcggct gccattgcca aggctggcat tccggtgtat gcctggaagg gcgaaacgga cgaggagtac ctgtggtgca ttgagcagac cctgtacttc aaggacgggc ccctcaacat gattctggac gacgggggcg acctcaccaa cctcatccac accaagtacc cgcagcttct gccaggcatc cgaggcatct ctgaggagac cacgactggg gtccacaacc tctacaagat gatggccaat gggatcctca aggtgcctgc catcaatgtc aatgactccg tcaccaagag caagtttgac aacctctatg gctgccggga gtccctcata gatggcatca agcgggccac agatgtgatg attgccggca aggtagcggt ggtagcaggc tatggtgatg tgggcaaggg ctgtgcccag gccctgcggg gtttcggagc ccgcgtcatc atcaccgaga ttgaccccat caacgcactg caggctgcca tggagggcta tgaggtgacc accatggatg aggcctgtca ggagggcaac atctttgtca ccaccacagg ctgtattgac atcatccttg gccggcactt tgagcagatg aaggatgatg ccattgtgtg taacattgga cactttgacg tggagatcga tgtcaagtgg ctcaacgaga acgccgtgga gaaggtgaac atcaagccgc aggtggaccg gtatcggttg aagaatgggc gccgcatcat cctgctggcc gagggtcggc tggtcaacct gggttgtgcc atgggccacc ccagcttcgt gatgagtaac tccttcacca accaggtgat ggcgcagatc gagctgtgga cccatccaga caagtacccc gttggggttc atttcctgcc caagaagctg gatgaggcag tggctgaagc ccacctgggc aagctgaatg tgaagttgac caagctaact gagaagcaag cccagtacct gggcatgtcc tgtgatggcc ccttcaagcc ggatcactac cgctactga. It is sometimes possible for the material contained within the vial of "AHCY, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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