RAPGEF4 cdna clone
RAPGEF4 cDNA Clone
Gene Names
RAPGEF4; EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII
Synonyms
RAPGEF4; RAPGEF4 cDNA Clone; RAPGEF4 cdna clone
Sequence
atgctctacaagaaatatcgacagtatatggcaggacttctggctcctccttatggtgttatggaaacgggctctaacaatgacaggattcctgacaaggagaacacacctctcattgaacctcacgttcctcttcgtcctgctaacaccattaccaaggtcccttcagagaagatcctcagagctggaaaaattttacgaaatgccattctctctcgagcacctcacatgataagagatagaaaataccacctaaagacatacagacaatgctgtgtgggaactgaactggtggactggatgatgcagcagacaccatgtgttcactcccggactcaagctgttggcatgtggcaagtcctgttagaagatggtgttctcaaccacgtggaccaggagcaccatttccaagacaaatatttattctatcgatttctggatgatgagcacgaggatgcccctttgcctactgaggaggagaagaaggagtgtgatgaggagctccaggacaccatgctgctgctgtcacagatgggccgcgacgcccacatgaggatgatccttcgcaaaccacctggccagaggactgtggatgacctagagattatctatgaggagcttcttcatattaaagccttatcccatctttctaccacagtgaaacgagagttagcaggtgttctcatttttgagtctcacgccaaaggagggactgtgttgtttaaccagggggaagaaggtacctcctggtacattattctaaaaggatcagtgaatgtagtcatttacggcaagggtgtggtctgcaccctgcatgaaggagatgacttcggcaagttagcactagtgaatgatgccccacgagctgcctctatcgtcttacgagaagataactgccatttcttaagagtagacaaggaggatttcaaccggatcctaagggacgtggaggcgaatacagtcagacttaaagaacatgaccaagatgtcttggtgctggagaaggtcccagcagggaacagagcttctaatcaaggaaactcacagcctcagcaaaagtatactgtgatgtcaggaacacctgaaaaaattttagagcgttttctagaaacaatacgccttgaggcaactttaaatgaagcaacagattctgttttaaatgactttattatgatgcactgtgtttttatgccaaatacccagctttgcccggcactggtggcccactaccacgcacagccttcacaaggtacagaacaggagaaaatggattatgccctcaacaataagaggcgagtcatccgcctggttctacagtgggctgccatgtatggagacctcctgcaagaggatgacgtgtctatggccttcctggaggagttttatgtatctgtatcagatgatgcccggatgattgctgccctcaaggagcaactgccagagttggagaagattgtcaagcaaatctcagaagatgcaaaggcaccacaaaagaagcacaaggttattttgcaacagttcaatacgggcgatgagagagcccagaagcgccagcctatccgcggctctgatgaagttctgtttaaggtctattgcatggaccacacctacacaaccattcgggtgccagtggccacttcggtgaaggaagtcatcagtgcagttgccgacaagctgggctccggggagggcctgatcatagtcaagatgagttccggaggagaaaaggtggtgctcaaacctaatgatgtttcagtatttacgacgctcaccattaatggacgcctgtttgcttgcccgcgagagcaattcgattcactgactccattaccagaacaggaaggcccaactgttggaacagtgggaacttttgaactgatgagctccaaagatttagcataccagatgacaatttatgattgggaactcttcaactgcgtgcatgagctggagctaatctatcacacatttggaaggcataattttaaaaagaccacagcaaacttggatttgttcctgaggagatttaatgaaattcagttttgggtcgtcactgagatctgcctttgttctcagctcagcaagcgtgttcagctattaaaaaaatttattaagatagcagcccactgtaaggagtataaaaatctgaattccttttttgccatcgtcatgggactaagtaacgttgctgtgagccgcttggcactaacgtgggagaaactgccaagcaagttcaagaagttctatgcggagtttgaaagtttaatggacacttcaaggaaccacagggcctacaggctgacagtagctaagctggaacctcctctcatccccttcatgcctttgctcattaaagatatgacatttactcatgaggggaacaagacgttcattgacaatctagtaaactttgaaaaaatgcgcatgattgcaaatacggccagaacagtgagatactacaggagccaacccttcaatcctgatgcagctcaagctaataagaaccatcaggatgtccggagttatgtacggcaattaaatgtgattgacaaccagagaactttatcacagatgtcacacagattagagcctcgtcgaccatag
Sequence Length
2604
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
96,269 Da
NCBI Official Full Name
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4, mRNA
NCBI Official Synonym Full Names
Rap guanine nucleotide exchange factor 4
NCBI Official Symbol
RAPGEF4
NCBI Official Synonym Symbols
EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII
NCBI Protein Information
rap guanine nucleotide exchange factor 4
UniProt Protein Name
Rap guanine nucleotide exchange factor 4
Protein Family
UniProt Gene Name
RAPGEF4
UniProt Synonym Gene Names
CGEF2; EPAC2; EPAC 2; cAMP-GEFII
UniProt Entry Name
RPGF4_HUMAN
Uniprot Description
RAPGEF4: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2. Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. 3 isoforms of the human protein are produced by alternative promoter.
Protein type: GEFs, Ras; GEFs
Chromosomal Location of Human Ortholog: 2q31-q32
Cellular Component: membrane; plasma membrane
Molecular Function: cAMP binding; guanyl-nucleotide exchange factor activity; protein binding; Ras GTPase binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: G-protein coupled receptor protein signaling pathway; regulation of insulin secretion
Research Articles on RAPGEF4
Similar Products
Product Notes
The RAPGEF4 rapgef4 (Catalog #AAA1272979) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgctctaca agaaatatcg acagtatatg gcaggacttc tggctcctcc ttatggtgtt atggaaacgg gctctaacaa tgacaggatt cctgacaagg agaacacacc tctcattgaa cctcacgttc ctcttcgtcc tgctaacacc attaccaagg tcccttcaga gaagatcctc agagctggaa aaattttacg aaatgccatt ctctctcgag cacctcacat gataagagat agaaaatacc acctaaagac atacagacaa tgctgtgtgg gaactgaact ggtggactgg atgatgcagc agacaccatg tgttcactcc cggactcaag ctgttggcat gtggcaagtc ctgttagaag atggtgttct caaccacgtg gaccaggagc accatttcca agacaaatat ttattctatc gatttctgga tgatgagcac gaggatgccc ctttgcctac tgaggaggag aagaaggagt gtgatgagga gctccaggac accatgctgc tgctgtcaca gatgggccgc gacgcccaca tgaggatgat ccttcgcaaa ccacctggcc agaggactgt ggatgaccta gagattatct atgaggagct tcttcatatt aaagccttat cccatctttc taccacagtg aaacgagagt tagcaggtgt tctcattttt gagtctcacg ccaaaggagg gactgtgttg tttaaccagg gggaagaagg tacctcctgg tacattattc taaaaggatc agtgaatgta gtcatttacg gcaagggtgt ggtctgcacc ctgcatgaag gagatgactt cggcaagtta gcactagtga atgatgcccc acgagctgcc tctatcgtct tacgagaaga taactgccat ttcttaagag tagacaagga ggatttcaac cggatcctaa gggacgtgga ggcgaataca gtcagactta aagaacatga ccaagatgtc ttggtgctgg agaaggtccc agcagggaac agagcttcta atcaaggaaa ctcacagcct cagcaaaagt atactgtgat gtcaggaaca cctgaaaaaa ttttagagcg ttttctagaa acaatacgcc ttgaggcaac tttaaatgaa gcaacagatt ctgttttaaa tgactttatt atgatgcact gtgtttttat gccaaatacc cagctttgcc cggcactggt ggcccactac cacgcacagc cttcacaagg tacagaacag gagaaaatgg attatgccct caacaataag aggcgagtca tccgcctggt tctacagtgg gctgccatgt atggagacct cctgcaagag gatgacgtgt ctatggcctt cctggaggag ttttatgtat ctgtatcaga tgatgcccgg atgattgctg ccctcaagga gcaactgcca gagttggaga agattgtcaa gcaaatctca gaagatgcaa aggcaccaca aaagaagcac aaggttattt tgcaacagtt caatacgggc gatgagagag cccagaagcg ccagcctatc cgcggctctg atgaagttct gtttaaggtc tattgcatgg accacaccta cacaaccatt cgggtgccag tggccacttc ggtgaaggaa gtcatcagtg cagttgccga caagctgggc tccggggagg gcctgatcat agtcaagatg agttccggag gagaaaaggt ggtgctcaaa cctaatgatg tttcagtatt tacgacgctc accattaatg gacgcctgtt tgcttgcccg cgagagcaat tcgattcact gactccatta ccagaacagg aaggcccaac tgttggaaca gtgggaactt ttgaactgat gagctccaaa gatttagcat accagatgac aatttatgat tgggaactct tcaactgcgt gcatgagctg gagctaatct atcacacatt tggaaggcat aattttaaaa agaccacagc aaacttggat ttgttcctga ggagatttaa tgaaattcag ttttgggtcg tcactgagat ctgcctttgt tctcagctca gcaagcgtgt tcagctatta aaaaaattta ttaagatagc agcccactgt aaggagtata aaaatctgaa ttcctttttt gccatcgtca tgggactaag taacgttgct gtgagccgct tggcactaac gtgggagaaa ctgccaagca agttcaagaa gttctatgcg gagtttgaaa gtttaatgga cacttcaagg aaccacaggg cctacaggct gacagtagct aagctggaac ctcctctcat ccccttcatg cctttgctca ttaaagatat gacatttact catgagggga acaagacgtt cattgacaat ctagtaaact ttgaaaaaat gcgcatgatt gcaaatacgg ccagaacagt gagatactac aggagccaac ccttcaatcc tgatgcagct caagctaata agaaccatca ggatgtccgg agttatgtac ggcaattaaa tgtgattgac aaccagagaa ctttatcaca gatgtcacac agattagagc ctcgtcgacc atag. It is sometimes possible for the material contained within the vial of "RAPGEF4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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