DAXX cdna clone
DAXX cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Uniprot Description
DAXX: a transcriptional co-regulatory protein. Proposed to mediate activation of the JNK pathway and apoptosis via ASK1 in response to signaling from FAS and TGF-betaR2. Glucose deprivation activates the ASK1-SEK1-JNK1-HIPK1 pathway, relocalizing Daxx from the nucleus to the cytoplasm, where Daxx binds to ASK1, and subsequently leads to ASK1 oligomerization. Interaction with HSP27 may prevent interaction with TGF-betaR2 and ASK1 and block DAXX-mediated apoptosis. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Two alternatively spliced isoforms have been described.
Protein type: Nucleolus; Nuclear receptor co-regulator; Apoptosis; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: chromosome, pericentric region; cytoplasm; cytosol; nucleoplasm; nucleus; PML body
Molecular Function: androgen receptor binding; enzyme binding; heat shock protein binding; histone binding; p53 binding; protein binding; protein kinase activator activity; protein kinase binding; protein N-terminus binding; receptor signaling protein activity; transcription corepressor activity; ubiquitin protein ligase binding
Biological Process: activation of JNK activity; androgen receptor signaling pathway; apoptosis; chromatin remodeling; induction of apoptosis via death domain receptors; negative regulation of transcription, DNA-dependent; nucleosome assembly; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase activity; regulation of protein ubiquitination; regulation of transcription, DNA-dependent
Research Articles on DAXX
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Product Notes
The DAXX daxx (Catalog #AAA1271448) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCCACCG CTAACAGCAT CATCGTGCTG GATGATGATG ACGAAGATGA AGCAGCTGCT CAGCCAGGGC CCTCCCACCC ACTCCCCAAT GCGGCCTCAC CTGGGGCAGA AGCCCCTAGC TCCTCTGAGC CTCATGGGGC CAGAGGAAGC AGTAGTTCGG GCGGCAAGAA ATGCTACAAG CTGGAGAATG AGAAGCTGTT CGAAGAGTTC CTTGAACTTT GTAAGATGCA GACAGCAGAC CACCCTGAGG TGGTCCCATT CCTCTATAAC CGGCAGCAAC GTGCCCACTC TCTGTTTTTG GCCTCGGCGG AGTTCTGCAA CATCCTCTCT AGGGTCCTGT CTCGGGCCCG GAGCCGGCCA GCCAAGCTCT ATGTCTACAT CAATGAGCTC TGCACTGTTC TCAAGGCCCA CTCAGCCAAA AAGAAGCTGA ACTTGGCCCC TGCCGCCACC ACCTCCAATG AGCCCTCTGG GAATAACCCT CCCACACACC TCTCCTTGGA CCCCACAAAT GCTGAAAACA CTGCCTCTCA GTCTCCAAGG ACCCGTGGTT CCCGGCGGCA GATCCAGCGT TTGGAGCAGC TGCTGGCGCT CTATGTGGCA GAGATCCGGC GGCTGCAGGA AAAGGAGTTG GATCTCTCAG AATTGGATGA CCCAGACTCC GCATACCTGC AGGAGGCACG GTTGAAGCGT AAGCTGATCC GCCTCTTTGG GCGACTATGT GAGCTGAAAG ACTGCTCTTC ACTGACCGGC CGTGTCATAG AGCAGCGCAT CCCCTACCGT GGCACCCGCT ACCCAGAGGT TAACAGGCGC ATTGAGCGGC TCATCAACAA GCCAGGGCCT GATACCTTCC CTGACTATGG GGATGTGCTT CGGGCTGTAG AGAAGGCAGC TGCCCGACAC AGCCTTGGCC TCCCCCGACA GCAGCTCCAG CTCATGGCTC AGGATGCCTT CCGAGATGTG GGCATCAGGT TACAGGAGCG ACGTCACCTC GATCTCATCT ACAACTTTGG CTGCCACCTC ACAGATGACT ATAGGCCAGG CGTTGACCCT GCACTATCAG ATCCTGTGTT GGCCCGGCGC CTTCGGGAAA ACCGGAGTTT GGCCATGAGT CGGCTGGATG AGGTCATCTC CAAATATGCA ATGTTGCAAG ACAAAAGTGA GGAGGGCGAG AGAAAAAAGA GAAGAGCTCG GCTCCAAGGC ACCTCTTCCC ACTCTGCAGA CACCCCCGAA GCCTCCTTGG ATTCTGGTGA GGGCCCTAGT GGAATGGCAT CCCAGGGGTG CCCTTCTGCC TCCAGAGCTG AGACAGATGA CGAAGACGAT GAGGAGAGTG ATGAGGAAGA GGAGGAGGAG GAGGAAGAAG AAGAGGAGGA GGCCACAGAT TCTGAAGAGG AGGAGGATCT GGAACAGATG CAGGAGGGTC AGGAGGATGA TGAAGAGGAG GACGAAGAGG AAGAAGCAGC AGCAGGTAAA GATGGAGACA AGAGCCCCAT GTCCTCACTA CAGATCTCCA ATGAAAAGAA CCTGGAACCT GGCAAACAGA TCAGCAGATC TTCAGGGGAG CAGCAAAACA AAGGACGCAT AGTGTCACCA TCGTTACTGT CAGAAGAACC CCTGGCCCCC TCCAGCATAG ATGCTGAAAG CAATGGAGAA CAGCCTGAGG AGCTGACCCT GGAGGAAGAA AGCCCTGTGT CTCAGCTCTT TGAGCTAGAG ATTGAAGCTT TGCCCCTGGA TACCCCTTCC TCTGTGGAGA CGGACATTTC CTCTTCCAGG AAGCAATCAG AGGAGCCCTT CACCACTGTC TTAGAGAATG GAGCAGGCAT GGTCTCTTCT ACTTCCTTCA ATGGAGGCGT CTCTCCTCAC AACTGGGGAG ATTCTGGTCC CCCCTGCAAA AAATCTCGGA AGGAGAAGAA GCAAACAGGA TCAGGGCCAT TAGGAAACAG CTATGTGGAA AGGCAAAGGT CAGTGCATGA GAAGAATGGG AAAAAGATAT GTACCCTGCC CAGCCCACCT TCCCCCTTGG CTTCCTTGGC CCCAGTTGCT GATTCCTCCA CGAGGGTGGA CTCTCCCAGC CATGGCCTGG TGACCAGCTC CCTCTGCATC CCTTCTCCAG CCCGGCTGTC CCAAACCCCC CATTCACAGC CTCCTCGGCC TGGTACTTGC AAGACAAGTG TGGCCACACA ATGCGATCCA GAAGAGATCA TCGTGCTCTC AGACTCTGAT TAG. It is sometimes possible for the material contained within the vial of "DAXX, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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