C1orf124 cdna clone
C1orf124 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Uniprot Description
SPRTN: Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Also required for localization of DNA polymerase eta (POLH) to sites of UV damage. Belongs to the Spartan family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 1q42.12-q43
Cellular Component: nuclear speck; nucleoplasm; nucleus
Molecular Function: protein binding; ubiquitin binding
Biological Process: bypass DNA synthesis; positive regulation of protein ubiquitination; response to DNA damage stimulus; response to UV
Disease: Ruijs-aalfs Syndrome
Research Articles on C1orf124
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Product Notes
The C1orf124 sprtn (Catalog #AAA1271419) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggatgatg acttgatgtt ggcactgcgg cttcaggagg agtggaactt gcaggaggcg gagcgcgatc atgcccagga gtccctgtcg ctagtggacg cgtcgtggga gttggtggac cccacaccgg acttgcaggc actgtttgtt cagtttaacg accaattctt ctggggccag ctggaggccg tcgaggtgaa gtggagcgtg cgaatgaccc tgtgtgctgg gatatgcagc tatgaaggga agggtggaat gtgttccatc cgtctcagcg aacccctttt gaagttgagg ccaagaaagg atcttgtaga gaccctcctg catgaaatga tacatgccta tttatttgtc actaataacg acaaagaccg agaagggcat ggtccagaat tttgtaaaca tatgcatcgc atcaacagcc tgactggagc caatataacg gtataccata cttttcacga tgaggtggat gagtatcggc gacactggtg gcgctgcaat gggccgtgcc agcacaggcc accgtattac ggctatgtca aacgagctac taacagggaa ccctctgctc atgactattg gtgggctgag caccagaaaa cctgtggagg cacttacata aaaatcaagg aaccagagaa ttactcaaaa aaaggcaaag gaaaggcaaa actaggaaag gaaccagtat tggccgcaga gaataaagat aaacccaaca gaggtgaggc ccagctagta atccctttta gtgggaaagg atatgttcta ggagaaacaa gcaatttacc ttcacctggg aaactgatca cttcacatgc cattaataaa acccaagatc ttttaaatca aaaccattca gcaaatgctg taagacttaa ttctaaaatc aaggtgaaat ttgaacagaa tggttcaagt aaaaattctc atctggtctc ccctgctgtt agtaacagtc accaaaatgt tctaagcaac tactttccta gagtatcatt tgccaaccaa aaggctttca gaggtgtgaa tggatctcca aggataagtg taacagttgg caacatccct aaaaactcag tctcttctag ttctcagaga agggtttcat cttctaagat atccctaaga aattcttcaa aagtaacgga atcagcatct gtgatgccat cccaggatgt gagtgggtct gaagatacat tcccaaataa acgacctagg ctagaagata agactgtttt tgacaatttt tttatcaaga aagagcaaat aaaaagcagt ggtaatgatc caaagtatag tacaaccaca gctcagaatt ccagcagttc atccagtcag agcaaaatgg ttaattgccc agtttgtcag aatgaagttc tggagtctca gattaatgag cacttggact ggtgccttga aggtgacagc atcaaagtca aaagcgaaga aagtctttga. It is sometimes possible for the material contained within the vial of "C1orf124, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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