ETS1 cdna clone
ETS1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Uniprot Description
Ets-1: a proto-oncogenic transcription factor homologous to the v-ets erythroblastosis virus oncogene. The DNA binding activity of Ets1 is controlled by kinases and transcription factors. It contributes to the regulation of cellular differentiation in hematopoietic cells. Ets1 promotes invasive behavior in endothelial cells, vascular smooth muscle cells and epithelial cancer cells. Regulates the expression of MMP1, MMP3, MMP9 and uPA as well as of VEGF and VEGFR gene expression. Two alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Transcription factor; Oncoprotein; DNA-binding
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA binding; identical protein binding; protein binding; transcription factor activity
Biological Process: cell motility involved in cell locomotion; immune response; negative regulation of cell proliferation; PML body organization and biogenesis; positive regulation of cell motility; positive regulation of erythrocyte differentiation; positive regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of angiogenesis
Research Articles on ETS1
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Product Notes
The ETS1 ets1 (Catalog #AAA1271142) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaaggcgg ccgtcgatct caagccgact ctcaccatca tcaagacgga aaaagtcgat ctggagcttt tcccctcccc ggatatggaa tgtgcagatg tcccactatt aactccaagc agcaaagaaa tgatgtctca agcattaaaa gctactttca gtggtttcac taaagaacag caacgactgg ggatcccaaa agacccccgg cagtggacag aaacccatgt tcgggactgg gtgatgtggg ctgtgaatga attcagcctg aaaggtgtag acttccagaa gttctgtatg aatggagcag ccctctgcgc cctgggtaaa gactgctttc tcgagctggc cccagacttt gttggggaca tcttatggga acatctagag atcctgcaga aagaggatgt gaaaccatat caagttaatg gagtcaaccc agcctatcca gaatcccgct atacctcgga ttacttcatt agctatggta ttgagcatgc ccagtgtgtt ccaccatcgg agttctcaga gcccagcttc atcacagagt cctatcagac gctccatccc atcagctcgg aagagctcct ctccctcaag tatgagaatg actacccctc ggtcattctc cgagaccctc tccagacaga caccttgcag aatgactact ttgctatcaa acaagaagtc gtcaccccag acaacatgtg catggggagg accagtcgtg gtaaactcgg gggccaggac tcttttgaaa gcatagagag ctacgatagt tgtggccagg agatggggaa agaggaaaaa caaacctaa. It is sometimes possible for the material contained within the vial of "ETS1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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