ITGAM cdna clone
ITGAM cDNA Clone
Gene Names
ITGAM; CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
Synonyms
ITGAM; ITGAM cDNA Clone; ITGAM cdna clone
Sequence
ATGGCTCTCAGAGTCCTTCTGTTAACAGCCTTGACCTTATGTCATGGGTTCAACTTGGACACTGAAAACGCAATGACCTTCCAAGAGAACGCAAGGGGCTTCGGGCAGAGCGTGGTCCAGCTTCAGGGATCCAGGGTGGTGGTTGGAGCCCCCCAGGAGATAGTGGCTGCCAACCAAAGGGGCAGCCTCTACCAGTGCGACTACAGCACAGGCTCATGCGAGCCCATCCGCCTGCAGGTCCCCGTGGAGGCCGTGAACATGTCCCTGGGCCTGTCCCTGGCAGCCACCACCAGCCCCCCTCAGCTGCTGGCCTGTGGTCCCACCGTGCACCAGACTTGCAGTGAGAACACGTATGTGAAAGGGCTCTGCTTCCTGTTTGGATCCAACCTACGGCAGCAGCCCCAGAAGTTCCCAGAGGCCCTCCGAGGGTGTCCTCAAGAGGATAGTGACATTGCCTTCTTGATTGATGGCTCTGGTAGCATCATCCCACATGACTTTCGGCGGATGAAGGAGTTTGTCTCAACTGTGATGGAGCAATTAAAAAAGTCCAAAACCTTGTTCTCTTTGATGCAGTACTCTGAAGAATTCCGGATTCACTTTACCTTCAAAGAGTTCCAGAACAACCCTAACCCAAGATCACTGGTGAAGCCAATAACGCAGCTGCTTGGGCGGACACACACGGCCACGGGCATCCGCAAAGTGGTACGAGAGCTGTTTAACATCACCAACGGAGCCCGAAAGAATGCCTTTAAGATCCTAGTTGTCATCACGGATGGAGAAAAGTTTGGCGATCCCTTGGGATATGAGGATGTCATCCCTGAGGCAGACAGAGAGGGAGTCATTCGCTACGTCATTGGGGTGGGAGATGCCTTCCGCAGTGAGAAATCCCGCCAAGAGCTTAATACCATCGCATCCAAGCCGCCTCGTGATCACGTGTTCCAGGTGAATAACTTTGAGGCTCTGAAGACCATTCAGAACCAGCTTCGGGAGAAGATCTTTGCGATCGAGGGTACTCAGACAGGAAGTAGCAGCTCCTTTGAGCATGAGATGTCTCAGGAAGGCTTCAGCGCTGCCATCACCTCTAATGGCCCCTTGCTGAGCACTGTGGGGAGCTATGACTGGGCTGGTGGAGTCTTTCTATATACATCAAAGGAGAAAAGCACCTTCATCAACATGACCAGAGTGGATTCAGACATGAATGATGCTTACTTGGGTTATGCTGCCGCCATCATCTTACGGAACCGGGTGCAAAGCCTGGTTCTGGGGGCACCTCGATATCAGCACATCGGCCTGGTAGCGATGTTCAGGCAGAACACTGGCACGTGGGAGTCCAACGCTAATGTCAAGGGCACCCAGATCGGCGCCTACTTCGGGGCCTCCCTCTGCTCCGTGGACGTGGACAGCAACGGCAGCACCGACCTGGTCCTCATCGGGGCCCCCCATTACTACGAGCAGACCCGAGGGGGCCAGGTGTCCGTGTGCCCCTTGCCCAGGGGGAGGGCTCGGTGGCAGTGTGATGCTGTTCTCTACGGGGAGCAGGGCCAACCCTGGGGCCGCTTTGGGGCAGCCCTAACAGTGCTGGGGGACGTAAATGGGGACAAGCTGACGGACGTGGCCATTGGGGCCCCAGGAGAGGAGGACAACCGGGGTGCTGTTTACCTGTTTCACGGAACCTCAGGATCTGGCATCAGCCCCTCCCATAGCCAGCGGATAGCAGGCTCCAAGCTCTCTCCCAGGCTCCAGTATTTTGGTCAGTCACTGAGTGGGGGCCAGGACCTCACAATGGATGGACTGGTAGACCTGACTGTAGGAGCCCAGGGGCACGTGCTGCTGCTCAGGTCCCAGCCAGTACTGAGAGTCAAGGCAATCATGGAGTTCAATCCCAGGGAAGTGGCAAGGAATGTATTTGAGTGTAATGATCAGGTGGTGAAAGGCAAGGAAGCCGGAGAGGTCAGAGTCTGCCTCCATGTCCAGAAGAGCACACGGGATCGGCTAAGAGAAGGACAGATCCAGAGTGTTGTGACTTATGACCTGGCTCTGGACTCCGGCCGCCCACATTCCCGCGCCGTCTTCAATGAGACAAAGAACAGCACACGCAGACAGACACAGGTCTTGGGGCTGACCCAGACTTGTGAGACCCTGAAACTACAGTTGCCGAATTGCATCGAGGACCCAGTGAGCCCCATTGTGCTGCGCCTGAACTTCTCTCTGGTGGGAACGCCATTGTCTGCTTTCGGGAACCTCCGGCCAGTGCTGGCGGAGGATGCTCAGAGACTCTTCACAGCCTTGTTTCCCTTTGAGAAGAATTGTGGCAATGACAACATCTGCCAGGATGACCTCAGCATCACCTTCAGTTTCATGAGCCTGGACTGCCTCGTGGTGGGTGGGCCCCGGGAGTTCAACGTGACAGTGACTGTGAGAAATGATGGTGAGGACTCCTACAGGACACAGGTCACCTTCTTCTTCCCGCTTGACCTGTCCTACCGGAAGGTGTCCACGCTCCAGAACCAGCGCTCACAGCGATCCTGGCGCCTGGCCTGTGAGTCTGCCTCCTCCACCGAAGTGTCTGGGGCCTTGAAGAGCACCAGCTGCAGCATAAACCACCCCATCTTCCCGGAAAACTCAGAGGTCACCTTTAATATCACGTTTGATGTAGACTCTAAGGCTTCCCTTGGAAACAAACTGCTCCTCAAGGCCAATGTGACCAGTGAGAACAACATGCCCAGAACCAACAAAACCGAATTCCAACTGGAGCTGCCGGTGAAATATGCTGTCTACATGGTGGTCACCAGCCATGGGGTCTCCACTAAATATCTCAACTTCACGGCCTCAGAGAATACCAGTCGGGTCATGCAGCATCAATATCAGGTCAGCAACCTGGGGCAGAGGAGCCTCCCCATCAGCCTGGTGTTCTTGGTGCCCGTCCGGCTGAACCAGACTGTCATATGGGACCGCCCCCAGGTCACCTTCTCCGAGAACCTCTCGAGTACGTGCCACACCAAGGAGCGCTTGCCCTCTCACTCCGACTTTCTGGCTGAGCTTCGGAAGGCCCCCGTGGTGAACTGCTCCATCGCTGTCTGCCAGAGAATCCAGTGTGACATCCCGTTCTTTGGCATCCAGGAAGAATTCAATGCTACCCTCAAAGGCAACCTCTCGTTTGACTGGTACATCAAGACCTCGCATAACCACCTCCTGATCGTGAGCACAGCTGAGATCTTGTTTAACGATTCCGTGTTCACCCTGCTGCCGGGACAGGGGGCGTTTGTGAGGTCCCAGACGGAGACCAAAGTGGAGCCGTTCGAGGTCCCCAACCCCCTGCCGCTCATCGTGGGCAGCTCTGTCGGGGGACTGCTGCTCCTGGCCCTCATCACCGCCGCGCTGTACAAGCTCGGCTTCTTTAAGCGGCAATACAAGGACATGATGAGTGAAGGGGGTCCCCCGGGGGCCGAACCCCAGTAG
Sequence Length
3459
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
127,307 Da
NCBI Official Full Name
Homo sapiens integrin, alpha M (complement component 3 receptor 3 subunit), mRNA
NCBI Official Synonym Full Names
integrin subunit alpha M
NCBI Official Symbol
ITGAM
NCBI Official Synonym Symbols
CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
NCBI Protein Information
integrin alpha-M
UniProt Protein Name
Integrin alpha-M
Protein Family
UniProt Gene Name
ITGAM
UniProt Synonym Gene Names
CD11B; CR3A
UniProt Entry Name
ITAM_HUMAN
NCBI Description
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Description
ITGAM: a single-pass type I membrane protein of the integrin alpha chain family. Implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Also known as CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. A receptor for fibrinogen, factor X and ICAM1. Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Predominantly expressed in monocytes and granulocytes.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cell surface; extracellular space; plasma membrane
Molecular Function: glycoprotein binding; protein binding
Biological Process: extracellular matrix organization and biogenesis; leukocyte migration; toll-like receptor 4 signaling pathway
Disease: Systemic Lupus Erythematosus, Susceptibility To, 6
Research Articles on ITGAM
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Product Notes
The ITGAM itgam (Catalog #AAA1270802) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCTCTCA GAGTCCTTCT GTTAACAGCC TTGACCTTAT GTCATGGGTT CAACTTGGAC ACTGAAAACG CAATGACCTT CCAAGAGAAC GCAAGGGGCT TCGGGCAGAG CGTGGTCCAG CTTCAGGGAT CCAGGGTGGT GGTTGGAGCC CCCCAGGAGA TAGTGGCTGC CAACCAAAGG GGCAGCCTCT ACCAGTGCGA CTACAGCACA GGCTCATGCG AGCCCATCCG CCTGCAGGTC CCCGTGGAGG CCGTGAACAT GTCCCTGGGC CTGTCCCTGG CAGCCACCAC CAGCCCCCCT CAGCTGCTGG CCTGTGGTCC CACCGTGCAC CAGACTTGCA GTGAGAACAC GTATGTGAAA GGGCTCTGCT TCCTGTTTGG ATCCAACCTA CGGCAGCAGC CCCAGAAGTT CCCAGAGGCC CTCCGAGGGT GTCCTCAAGA GGATAGTGAC ATTGCCTTCT TGATTGATGG CTCTGGTAGC ATCATCCCAC ATGACTTTCG GCGGATGAAG GAGTTTGTCT CAACTGTGAT GGAGCAATTA AAAAAGTCCA AAACCTTGTT CTCTTTGATG CAGTACTCTG AAGAATTCCG GATTCACTTT ACCTTCAAAG AGTTCCAGAA CAACCCTAAC CCAAGATCAC TGGTGAAGCC AATAACGCAG CTGCTTGGGC GGACACACAC GGCCACGGGC ATCCGCAAAG TGGTACGAGA GCTGTTTAAC ATCACCAACG GAGCCCGAAA GAATGCCTTT AAGATCCTAG TTGTCATCAC GGATGGAGAA AAGTTTGGCG ATCCCTTGGG ATATGAGGAT GTCATCCCTG AGGCAGACAG AGAGGGAGTC ATTCGCTACG TCATTGGGGT GGGAGATGCC TTCCGCAGTG AGAAATCCCG CCAAGAGCTT AATACCATCG CATCCAAGCC GCCTCGTGAT CACGTGTTCC AGGTGAATAA CTTTGAGGCT CTGAAGACCA TTCAGAACCA GCTTCGGGAG AAGATCTTTG CGATCGAGGG TACTCAGACA GGAAGTAGCA GCTCCTTTGA GCATGAGATG TCTCAGGAAG GCTTCAGCGC TGCCATCACC TCTAATGGCC CCTTGCTGAG CACTGTGGGG AGCTATGACT GGGCTGGTGG AGTCTTTCTA TATACATCAA AGGAGAAAAG CACCTTCATC AACATGACCA GAGTGGATTC AGACATGAAT GATGCTTACT TGGGTTATGC TGCCGCCATC ATCTTACGGA ACCGGGTGCA AAGCCTGGTT CTGGGGGCAC CTCGATATCA GCACATCGGC CTGGTAGCGA TGTTCAGGCA GAACACTGGC ACGTGGGAGT CCAACGCTAA TGTCAAGGGC ACCCAGATCG GCGCCTACTT CGGGGCCTCC CTCTGCTCCG TGGACGTGGA CAGCAACGGC AGCACCGACC TGGTCCTCAT CGGGGCCCCC CATTACTACG AGCAGACCCG AGGGGGCCAG GTGTCCGTGT GCCCCTTGCC CAGGGGGAGG GCTCGGTGGC AGTGTGATGC TGTTCTCTAC GGGGAGCAGG GCCAACCCTG GGGCCGCTTT GGGGCAGCCC TAACAGTGCT GGGGGACGTA AATGGGGACA AGCTGACGGA CGTGGCCATT GGGGCCCCAG GAGAGGAGGA CAACCGGGGT GCTGTTTACC TGTTTCACGG AACCTCAGGA TCTGGCATCA GCCCCTCCCA TAGCCAGCGG ATAGCAGGCT CCAAGCTCTC TCCCAGGCTC CAGTATTTTG GTCAGTCACT GAGTGGGGGC CAGGACCTCA CAATGGATGG ACTGGTAGAC CTGACTGTAG GAGCCCAGGG GCACGTGCTG CTGCTCAGGT CCCAGCCAGT ACTGAGAGTC AAGGCAATCA TGGAGTTCAA TCCCAGGGAA GTGGCAAGGA ATGTATTTGA GTGTAATGAT CAGGTGGTGA AAGGCAAGGA AGCCGGAGAG GTCAGAGTCT GCCTCCATGT CCAGAAGAGC ACACGGGATC GGCTAAGAGA AGGACAGATC CAGAGTGTTG TGACTTATGA CCTGGCTCTG GACTCCGGCC GCCCACATTC CCGCGCCGTC TTCAATGAGA CAAAGAACAG CACACGCAGA CAGACACAGG TCTTGGGGCT GACCCAGACT TGTGAGACCC TGAAACTACA GTTGCCGAAT TGCATCGAGG ACCCAGTGAG CCCCATTGTG CTGCGCCTGA ACTTCTCTCT GGTGGGAACG CCATTGTCTG CTTTCGGGAA CCTCCGGCCA GTGCTGGCGG AGGATGCTCA GAGACTCTTC ACAGCCTTGT TTCCCTTTGA GAAGAATTGT GGCAATGACA ACATCTGCCA GGATGACCTC AGCATCACCT TCAGTTTCAT GAGCCTGGAC TGCCTCGTGG TGGGTGGGCC CCGGGAGTTC AACGTGACAG TGACTGTGAG AAATGATGGT GAGGACTCCT ACAGGACACA GGTCACCTTC TTCTTCCCGC TTGACCTGTC CTACCGGAAG GTGTCCACGC TCCAGAACCA GCGCTCACAG CGATCCTGGC GCCTGGCCTG TGAGTCTGCC TCCTCCACCG AAGTGTCTGG GGCCTTGAAG AGCACCAGCT GCAGCATAAA CCACCCCATC TTCCCGGAAA ACTCAGAGGT CACCTTTAAT ATCACGTTTG ATGTAGACTC TAAGGCTTCC CTTGGAAACA AACTGCTCCT CAAGGCCAAT GTGACCAGTG AGAACAACAT GCCCAGAACC AACAAAACCG AATTCCAACT GGAGCTGCCG GTGAAATATG CTGTCTACAT GGTGGTCACC AGCCATGGGG TCTCCACTAA ATATCTCAAC TTCACGGCCT CAGAGAATAC CAGTCGGGTC ATGCAGCATC AATATCAGGT CAGCAACCTG GGGCAGAGGA GCCTCCCCAT CAGCCTGGTG TTCTTGGTGC CCGTCCGGCT GAACCAGACT GTCATATGGG ACCGCCCCCA GGTCACCTTC TCCGAGAACC TCTCGAGTAC GTGCCACACC AAGGAGCGCT TGCCCTCTCA CTCCGACTTT CTGGCTGAGC TTCGGAAGGC CCCCGTGGTG AACTGCTCCA TCGCTGTCTG CCAGAGAATC CAGTGTGACA TCCCGTTCTT TGGCATCCAG GAAGAATTCA ATGCTACCCT CAAAGGCAAC CTCTCGTTTG ACTGGTACAT CAAGACCTCG CATAACCACC TCCTGATCGT GAGCACAGCT GAGATCTTGT TTAACGATTC CGTGTTCACC CTGCTGCCGG GACAGGGGGC GTTTGTGAGG TCCCAGACGG AGACCAAAGT GGAGCCGTTC GAGGTCCCCA ACCCCCTGCC GCTCATCGTG GGCAGCTCTG TCGGGGGACT GCTGCTCCTG GCCCTCATCA CCGCCGCGCT GTACAAGCTC GGCTTCTTTA AGCGGCAATA CAAGGACATG ATGAGTGAAG GGGGTCCCCC GGGGGCCGAA CCCCAGTAG. It is sometimes possible for the material contained within the vial of "ITGAM, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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