NUMB cdna clone
NUMB cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Description
NUMB: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. Interacts with CDH1 and TFAP2B. Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: cell-cell adherens junction; clathrin-coated vesicle; focal adhesion; plasma membrane
Molecular Function: protein binding
Biological Process: lateral ventricle development; neuroblast division in the subventricular zone; positive regulation of cell migration; positive regulation of neurogenesis
Research Articles on NUMB
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Product Notes
The NUMB numb (Catalog #AAA1270303) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaacaaat tacggcaaag ttttaggaga aagaaggatg tttatgttcc agaggccagt cgtccacatc agtggcagac agatgaagaa ggcgttcgca ccggaaaatg tagcttcccg gttaagtacc ttggccatgt agaagttgat gaatcaagag gaatgcacat ctgtgaagat gctgtaaaaa gattgaaagc tactggaaag aaagcagtta aagcagttct gtgggtctca gcagatggac tcagagttgt ggatgaaaaa actaaggacc tcatagttga ccagacgata gagaaagttt ctttctgtgc cccagacagg aactttgata gagccttttc ttacatatgc cgtgatggca ccactcgtcg ctggatctgt cactgcttca tggctgtcaa ggacacaggt gaaaggttga gccatgcagt aggctgtgct tttgcagcct gtttagagcg caagcagaag cgggagaagg aatgtggagt gactgctact tttgatgcta gtcggaccac ttttacaaga gaaggatcat tccgtgtcac aacagccact gaacaagcag aaagagagga gatcatgaaa caaatgcaag atgccaagaa aggtacaatc tgttctacag tgtgtattta tggaatgcag tttttcccaa caaggtatta ttttgaagct accaggggta aattttctca taatcaaaga gaacccttag caatataa. It is sometimes possible for the material contained within the vial of "NUMB, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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