BLNK cdna clone
BLNK cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Description
BLNK: an adaptor protein that bridges the B-cell receptor-associated kinases (BCR) with a multitude of signaling pathways, regulating biologic outcomes of B-cell function and development. Plays an important role in BCR-mediated PLCG1 activation and Ca(2 ) mobilization. Does not seem to be not required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Its phosphorylation is required for both Ca(2 ) and MAPK signaling pathways. Defects in BLNK are the cause of hypoglobulinemia and absent B-cells.It has tumor supressor activity that is lost in many cases of childhood pre-B acute lymphoblastic leukemia (ALL). Two alternatively spliced isoforms have been described; these are differentially involved in activation and apoptosis of B lymphocytes.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 10q23.2-q23.33
Cellular Component: cytoplasm; cytosol; plasma membrane
Molecular Function: protein binding; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor protein activity
Biological Process: humoral immune response; inflammatory response
Disease: Agammaglobulinemia 4, Autosomal Recessive
Research Articles on BLNK
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Product Notes
The BLNK blnk (Catalog #AAA1270295) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggacaagc ttaataaaat aaccgtcccc gccagtcaga agttgaggca gcttcaaaag atggtccatg atattaaaaa caatgaaggt ggaataatga ataaaatcaa aaagctaaaa gtcaaagcac ctccaagtgt tcctcgaagg gactacgctt cagagagccc tgctgacgaa gagcagcagt ggtccgatga ctttgacagc gactatgaaa atccagatga gcactcggac tcagagatgt acgtgatgcc cgccgaggag aacgctgatg acagctacga gccgcctcca gtagagcagg aaaccaggcc ggttcaccca gccctgccct tcgccagagg cgagtatata gacaatcgat caagccagag gcattcccca cccttcagca agacacttcc cagtaagccc agctggcctt cagagaaagc aaggctcacc tccaccctgc cggccctgac tgctttgcag aaacctcaag tcccacccaa acccaaaggc ctccttgagg atgaggctga ttatgtggtc cccgtggaag ataatgatga aaactatatt catcccacag aaagcagttc acctccacct gaaaaagctc ccatggtgaa tagatcaacc aagccaaatt cctcaacgcc cgcctctcct ccaggaacag cttcaggtcg aaacagtggg gcctgggaaa ccaagtcacc tccaccagct gcaccatccc cgttgccacg ggccgggaaa aaaccaacga caccactgaa gacaactcca gttgcctctc aacagaatgc ttcaagtgtt tgtgaagaaa aacctatacc tgctgaacgc caccgagggt caagtcacag acaagaagct gtgcagtcac cagtgtttcc tcctgcccag aaacaaatcc accaaaaacc catacctctg ccaagattta cagaaggggg aaacccaact gtggatgggc ccctacccag cttttcatct aattccacta tttcagaaca ggaagctggc gttctctgca agccatggta tgctggagcc tgtgatcgaa agtctgctga agaggcattg cacagatcaa acaaggatgg atcatttctt attcggaaaa gctctggcca tgattccaaa caaccatata cactagttgt attctttaat aagcgagtat ataatattcc tgtgcgattt attgaagcaa caaaacaata tgccttgggc agaaagaaaa atggtgaaga gtactttgga agtgttgctg aaatcatcag gaatcatcaa catagtcctt tggttcttat tgacagtcag aataacacaa aagattccac cagactgaag tatgcagtta aagtttcata a. It is sometimes possible for the material contained within the vial of "BLNK, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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