TXNRD1 cdna clone
TXNRD1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
TRXR1: a cytoplasmic pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity.
Protein type: Nuclear receptor co-regulator; Oxidoreductase; Nucleotide Metabolism - pyrimidine; EC 1.8.1.9
Chromosomal Location of Human Ortholog: 12q23-q24.1
Cellular Component: cytosol
Molecular Function: protein binding; thioredoxin-disulfide reductase activity
Biological Process: nucleobase, nucleoside and nucleotide interconversion; response to reactive oxygen species; selenium metabolic process
Research Articles on TXNRD1
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Product Notes
The TXNRD1 txnrd1 (Catalog #AAA1270025) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaacggcc ctgaagatct tcccaagtcc tatgactatg accttatcat cattggaggt ggctcaggag gtctggcagc tgctaaggag gcagcccaat atggcaagaa ggtgatggtc ctggactttg tcactcccac ccctcttgga actagatggg gtcttggagg aacatgtgtg aatgtgggtt gcatacctaa aaaactgatg catcaagcag ctttgttagg acaagccctg caagactctc gaaattatgg atggaaagtc gaggagacag ttaagcatga ttgggacaga atgatagaag ctgtacagaa tcacattggc tctttgaatt ggggctaccg agtagctctg cgggagaaaa aagtcgtcta tgagaatgct tatgggcaat ttattggtcc tcacaggatt aaggcaacaa ataataaagg caaagaaaaa atttattcag cagagagatt tctcattgcc actggtgaaa gaccacgtta cttgggcatc cctggtgaca aagaatactg catcagcagt gatgatcttt tctccttgcc ttactgcccg ggtaagaccc tggttgttgg agcatcctat gtcgctttgg agtgcgctgg atttcttgct ggtattggtt tagacgtcac tgttatggtt aggtccattc ttcttagagg atttgaccag gacatggcca acaaaattgg tgaacacatg gaagaacatg gcatcaagtt tataagacag ttcgtaccaa ttaaagttga acaaattgaa gcagggacac caggccgact cagagtagta gctcagtcca ccaatagtga ggaaatcatt gaaggagaat ataatacggt gatgctggca ataggaagag atgcttgcac aagaaaaatt ggcttagaaa ccgtaggggt gaagataaat gaaaagactg gaaaaatacc tgtcacagat gaagaacaga ccaatgtgcc ttacatctat gccattggcg atatattgga ggataaggtg gagctcaccc cagttgcaat ccaggcagga agattgctgg ctcagaggct ctatgcaggt tccactgtca agtgtgacta tgaaaatgtt ccaaccactg tatttactcc tttggaatat ggtgcttgtg gcctttctga ggagaaagct gtggagaagt ttggggaaga aaatattgag gtttaccata gttacttttg gccattggaa tggacgattc cgtcaagaga taacaacaaa tgttatgcaa aaataatctg taatactaaa gacaatgaac gtgttgtggg ctttcacgta ctgggtccaa atgctggaga agttacacaa ggctttgcag ctgcgctcaa atgtggactg accaaaaagc agctggacag cacaattgga atccaccctg tctgtgcaga ggtattcaca acattgtctg tgaccaagcg ctctggggca agcatcctcc aggctggctg ctgaggttaa. It is sometimes possible for the material contained within the vial of "TXNRD1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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