WDR4 cdna clone
WDR4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Description
WDR4: a WD40 repeat protein. Required for 7-methylguanosine modification of tRNA. Forms a complex with METTL1. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: protein binding; tRNA (guanine-N7-)-methyltransferase activity
Biological Process: tRNA modification
Research Articles on WDR4
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Product Notes
The WDR4 wdr4 (Catalog #AAA1269790) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgctgttag atgtggctgt gagtcctgat gaccgcttca tcctcactgc cgaccgggac gagaagatcc gagtcagctg ggccgcggcg ccccatagca tcgagtcctt ctgcttgggg cacacagagt ttgtgagccg tatctccgtg gtgccaactc agcccgggct gcttctgtcc tcctctgggg acggcaccct gaggctctgg gagtacagga gcggccgcca gctgcactgc tgtcacctgg ccagtctgca ggagctggtg gacccccagg ccccccagaa gtttgccgcg tccaggattg cattctggtg ccaggagaac tgcgtggcgc tcctgtgcga cggcacttct gtggtctaca tcttccagct ggacgcccgc agacagcagt tggtgtacag gcagcagctg gcgttccagc accaagtgtg ggacgtggct ttcgaggaga cccaggggct gtgggtgctc caggactgcc aggaagcccc cctggtgctc tacaggcctg tgggcgacca gtggcagtct gttcctgaga gcaccgtgtt aaagaaagtc tctggtgttc ttcgtgggaa ctgggccatg ctggaaggct ctgccggcgc agacgccagc ttcagcagtc tctacaaggc cacgttcgac aacgtgacct cctacctgaa gaagaaagag gagagactgc agcagcagct agagaagaag cagcggcgcc ggagtccccc gcctgggccc gacgggcatg ccaagaagat gagaccgggg gaggcgacgc taagttgctg a. It is sometimes possible for the material contained within the vial of "WDR4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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