SLC29A4 cdna clone
SLC29A4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the SLC29A/ENT transporter protein family. The encoded membrane protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Description
SLC29A4: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia. Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7p22.1
Cellular Component: plasma membrane
Molecular Function: nucleoside transmembrane transporter activity
Research Articles on SLC29A4
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Product Notes
The SLC29A4 slc29a4 (Catalog #AAA1269697) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgggctccg tggggagcca gcgccttgag gagcccagcg tggcaggcac accagacccg ggcgtagtga tgagcttcac cttcgacagt caccagctgg aggaggcggc ggaggcggct cagggccagg gccttagggc caggggcgtc ccagctttca cggatactac attggacgag ccagtgcccg atgaccgtta tcacgccatc tactttgcga tgctgctggc tggcgtgggc ttcctgctgc catacaacag cttcatcacg gacgtggact acctgcatca caagtaccca gggacctcca tcgtgtttga catgagcctc acctacatct tggtggcact ggcagctgtc ctcctgaaca acgtcctggt ggagagactg accctgcaca ccaggatcac cgcagcatct gcgacgtgtg gctgcagctc ttctctcggg accaggccta cgccatcaac ctggccgctg tgggcaccgt ggccttcggc tgcacagcaa tccagcttct acgggtacac ggggatgctg cccaagcggt acacgcaggg ggtgatgacc ggggagagca cggcgggcgt gatgatctct ctgagccgca tcctcacgaa gctgctgctg cccgacgagc gcgccagcac gctcatcttc ttcctggtgt cggtggcgct ggagctgctg tgtttcctgc tgcacctgtt agtgcggcgc agccgcttcg tgctcttcta taccacacgg ccgcgtgaca gccaccgggg caggccaggc ctgggcaggg gctatggcta ccgcgtgcac cacgacgttg tcgccgggga cgtccacttc gagcacccag ccccggccct ggcccccaac gagtccccaa aggacagccc agcccacgag gtgaccggca gcggcggggc ctacatgcgc tttgacgtgc cgcggccaag ggtccagcgc agctggccca ccttcagagc cctgttactg caccgctacg tggtggcgcg ggtgatctgg gccgacatgc tctccatcgc cgtgacctac ttcatcacgc tgtgcctgtt ccccggcctc gagtctgaga tccgccactg catcctgggc gagtggctgc ccatcctcat catggctgtg ttcaacctgt cagacttcgt gggcaagatc ctggcagccc tgcccgtgga ctggcggggc acccacctgc tggcctgctc ctgcctgcgt gtggtcttca tccccctctt catcctgtgc gtctacccca gcggcatgcc cgccctccgt caccccgcct ggccctgcat cttctcactg ctcatgggca tcagcaacgg ctacttcggc agcgtgccca tgatcctggc ggcaggcaaa gtgagcccca agcagcggga gctggcaggg aacaccatga ccgtgtccta catgtcaggg ctgacgctgg ggtccgccgt ggcctactgc acctacagcc tcacccgcga cgctcacggc agctgcctgc acgcctccac cgccaatggt tccatcctcg caggcctctg a. It is sometimes possible for the material contained within the vial of "SLC29A4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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