XRCC5 cdna clone
XRCC5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
Uniprot Description
Ku80: the 80-kilodalton subunit of the Ku complex, also known as ATP-dependant DNA helicase II. A single stranded DNA-dependent ATP-dependent helicase. It functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70.
Protein type: RNA-binding; EC 3.6.1.-; EC 3.6.4.-; DNA-binding; Helicase; Nucleolus; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: cytosol; membrane; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm; nucleus; plasma membrane
Molecular Function: 5'-deoxyribose-5-phosphate lyase activity; damaged DNA binding; double-stranded DNA binding; double-stranded telomeric DNA binding; protein binding; protein C-terminus binding; telomeric DNA binding; ubiquitin protein ligase binding
Biological Process: double-strand break repair; double-strand break repair via nonhomologous end joining; negative regulation of transcription, DNA-dependent; positive regulation of interferon type I production; regulation of smooth muscle cell proliferation; telomere maintenance
Research Articles on XRCC5
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Product Notes
The XRCC5 xrcc5 (Catalog #AAA1269493) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggtgcggt cggggaataa ggcagctgtt gtgctgtgta tggacgtggg ctttaccatg agtaactcca ttcctggtat agaatcccca tttgaacaag caaagaaggt gataaccatg tttgtacagc gacaggtgtt tgctgagaac aaggatgaga ttgctttagt cctgtttggt acagatggca ctgacaatcc cctttctggt ggggatcagt atcagaacat cacagtgcac agacatctga tgctaccaga ttttgatttg ctggaggaca ttgaaagcaa aatccaacca ggttctcaac aggctgactt cctggatgca ctaatcgtga gcatggatgt gattcaacat gaaacaatag gaaagaagtt tgagaagagg catattgaaa tattcactga cctcagcagc cgattcagca aaagtcagct ggatattata attcatagct tgaagaaatg tgacatctcc ctgcaattct tcttgccttt ctcacttggc aaggaagatg gaagtgggga cagaggagat ggcccctttc gcttaggtgg ccatgggcct tcctttccac taaaaggaat taccgaacag caaaaagaag gtcttgagat agtgaaaatg gtgatgatat ctttagaagg tgaagatggg ttggatgaaa tttattcatt cagtgagagt ctgagaaaac tgtgcgtctt caagaaaatt gagaggcatt ccattcactg gccctgccga ctgaccattg gctccaattt gtctataagg attgcagcct ataaatcgat tctacaggag agagttaaaa agacttggac agttgtggat gcaaaaaccc taaaaaaaga agatatacaa aaagaaacag tttattgctt aaatgatgat gatgaaactg aagttttaaa agaggatatt attcaagggt tccgctatgg aagtgatata gttcctttct ctaaagtgga tgaggaacaa atgaaatata aatcggaggg gaagtgcttc tctgttttgg gattttgtaa atcttctcag gttcagagaa gattcttcat gggaaatcaa gttctaaagg tctttgcagc aagagatgat gaggcagctg cagttgcact ttcctccctg attcatgctt tggatgactt agacatggtg gccatagttc gatatgctta tgacaaaaga gctaatcctc aagtcggcgt ggcttttcct catatcaagc ataactatga gtgtttagtg tatgtgcagc tgcctttcat ggaagacttg cggcaataca tgttttcatc cttgaaaaac agtaagaaat atgctcccac cgaggcacag ttgaatgctg ttgatgcttt gattgactcc atgagcttgg caaagaaaga tgagaagaca gacacccttg aagacttgtt tccaaccacc aaaatcccaa atcctcgatt tcagagatta tttcagtgtc tgctgcacag agctttacat ccccgggagc ctctaccccc aattcagcag catatttgga atatgctgaa tcctcccgct gaggtgacaa cgaaaagtca gattcctctc tctaaaataa agaccctttt tcctctgatt gaagccaaga aaaaggatca agtgactgct caggaaattt tccaagacaa ccatgaagat ggacctacag ctaaaaaatt aaagactgag caagggggag cccacttcag cgtctccagt ctggctgaag gcagtgtcac ctctgttgga agtgtgaatc ctgctgaaaa cttccgtgtt ctagtgaaac agaagaaggc cagctttgag gaagcgagta accagctcat aaatcacatc gaacagtttt tggatactaa tgaaacaccg tattttatga agagcataga ctgcatccga gccttccggg aagaagccat taagttttca gaagagcagc gctttaacaa cttcctgaaa gcccttcaag agaaagtgga aattaaacaa ttaaatcatt tctgggaaat tgttgtccag gatggaatta ctctgatcac caaagaggaa gcctctggaa gttctgtcac agctgaggaa gccaaaaagt ttctggcccc caaagacaaa ccaagtggag acacagcagc tgtatttgaa gaaggtggtg atgtggacga tttattggac atgatatag. It is sometimes possible for the material contained within the vial of "XRCC5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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