ARHGEF7 cdna clone
ARHGEF7 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]
Uniprot Description
ARHGEF7: a RAC1 guanine nucleotide exchange factor (GEF). Can induce membrane ruffling. Interacts with PAK kinases through its SH3 domain. Acts both as an activator and a downstream target for Cdc42. Its EGF-dependent phosphorylation activates its nucleotide exchange factor for Cdc42 and regulates its interaction with the E3 ligase Cbl, thus modulating Cbl-catalysed EGFR degradation. Its phosphorylation status is necessary to maintain the balance between normal signaling by EGFR and Src versus aberrant growth and transformation. Four alternatively spliced isoforms have been described.
Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: cell soma; cytosol; focal adhesion; lamellipodium; neuron projection; protein complex
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein kinase binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: ephrin receptor signaling pathway; focal adhesion formation; Golgi organization and biogenesis; lamellipodium biogenesis; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction
Research Articles on ARHGEF7
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Product Notes
The ARHGEF7 arhgef7 (Catalog #AAA1269073) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaattccg ccgagcaaac cgttacgtgg ctcatcactc tgggggtgct ggagtcgccc aaaaaaacca tctcggaccc ggagggcttt ctgcaggcgt cgctgaagga tggggtggtc ctctgcaggc tgctggagcg cctgctcccc gggaccatcg agaaaacgtt tgatgcaaat gatttgtatc aggggcagaa ttttaacaag gtcctcagtt ccttagtgac tctaaataaa gtaacagcag acatcgggct ggggagtgac tccgtgtgtg cccggccctc gtctcaccgc ataaagtctt ttgactccct tggatcacag tctttgcaca ctcggacttc aaaactgttc cagggccagt atcggagttt ggacatgacc gataatagca acaatcaact ggtagtaaga gcaaagttta acttccagca gaccaatgag gacgagcttt ccttctcaaa aggagacgtc atccatgtca cccgtgtgga agagggaggc tggtgggagg gcacactcaa cggccggacc ggctggttcc ccagcaacta cgtgcgcgag gtcaaggcca gcgagaagcc tgtgtctccc aaatcaggaa cactgaagag ccctcccaaa ggatttgata cgactgccat aaacaaaagc tattacaatg tggtgctaca gaatatttta gaaacagaaa atgaatattc taaagaactt cagactgtgc tttcaacgta cctacggcca ttgcagacca gtgagaagtt aagttcagca aacatttcat atttaatggg aaatctagaa gaaatatgtt ctttccagca aatgctcgta cagtctttag aagaatgcac caagttgccc gaagctaagc agagagtcgg aggctgcttt ttaaacctga tgccacagat gaaaaccctg tacctcacgt attgtgccaa tcacccttct gcagtgaatg tcctcacgga acacagtgag gagttggggg agttcatgga gaccaaaggt gccagcagcc ctgggattct cgtgctgacc acgggcctga gcaaaccctt catgcgcctg gataaatacc ctacgctgct caaagagctc gagagacaca tggaggatta tcatacagat agacaagata ttcaaaaatc catggctgcc ttcaaaaacc tttcagccca atgtcaagaa gtccggaaga ggaaagagct tgagctgcag atcctgacgg aagccatccg gaactgggag ggcgatgaca ttaaaactct gggcaacgtc acttacatgt cccaggtcct gattcagtgt gccggaagtg aggaaaagaa tgaaagatat cttctactct tcccaaatgt tttgctaatg ttgtctgcca gtcctaggat gagtggcttt atctatcagg gaaagcttcc aacgacagga atgacaatca caaagcttga ggacagtgaa aatcatagaa atgcatttga aatatcaggg agcgtgattg agcggatatt agtgtcgtgc aacaaccagc aggatctgca ggaatgggtg gagcacctac agaagcaaac gaaggtcacg tctgtgggaa accccaccat aaagcctcat tcagtgccat ctcataccct cccctcccac ccggtcactc cgtccagcaa gcacgcagac agcaagcccg cgccgctgac gcccgcctac cacacgctgc cccacccctc ccaccacggc accccgcaca ccaccatcaa ctggggaccc ctggagcctc cgaaaacacc caagccctgg agcctgagct gcctgcggcc cgcgcctccc ctccggccct cagctgctct ctgctacaag gaggatctta gtaagagccc taagaccatg aaaaagctgc tgcccaagcg caaacctgaa cggaagcctt cagatgagga gttcgcgtcc cggaaaagca cagctgcttt ggaagaagat gctcagattc tgaaagtcat tgaagcttac tgcaccagcg ccaaaacaag gcaaacactc aattcaacat ggcaaggcac tgacctgttg cataatcacg tcttggctga tgatgaccaa ccaagcctag actccctggg gcgtcgcagt agcctttctc gtttggagcc ttcagacctc tcggaagact ctgactatga cagtatatgg acagcccata gttacagaat gggttctaca tctcgtaaga gctgttgctc atatatctct caccagaact aa. It is sometimes possible for the material contained within the vial of "ARHGEF7, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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