ARHGEF2 cdna clone
ARHGEF2 cDNA Clone
Gene Names
ARHGEF2; GEF; P40; GEFH1; LFP40; GEF-H1
Synonyms
ARHGEF2; ARHGEF2 cDNA Clone; ARHGEF2 cdna clone
Sequence
atgaaggaagccaaggatgcccgctataccaatgggcacctcttcaccaccatttcagtttcaggcatgaccatgtgctatgcctgtaacaagagcatcacagccaaggaagccctcatctgcccaacctgcaatgtgactatccacaaccgctgtaaagacaccctcgccaactgtaccaaggtcaagcagaagcaacagaaagcggccctgctgaagaacaacaccgccttgcagtccgtttctcttcgaagtaagacaaccatccgggagcggccaagctcggccatctacccctccgacagcttccggcagtccctcctgggctcccgccgtggccgctcctccttgtctttagccaagagtgtttctaccaccaacattgctggacatttcaatgatgagtctcccctggggctgcgccggatcctctcacagtccacagactccctcaacatgcggaaccgaaccctatccgtggaatccctcattgacgaagcagaggtaatctacagtgagctgatgagtgactttgagatggatgagaaggactttgcagctgactcttggagtcttgctgtggacagcagcttcctgcagcagcataaaaaggaggtgatgaagcagcaagatgtcatctatgagctaatccagacagagctgcaccatgtgaggacactgaagatcatgacccgcctcttccgcacggggatgctggaagagctacacttggagccaggagtggtccagggcctgttcccctgcgtggacgagctcagtgacatccatacacgcttcctcagccagctattagaacgccgacgccaggccctgtgccctggcagcacccggaactttgtcatccatcgcttgggtgatctgctcatcagccagttctcaggtcctagtgcggagcagatgtgtaagacctactcggagttctgcagccgccacagcaaggccttaaagctctataaggagctgtacgcccgagacaaacgcttccagcaattcatccggaaagtgacccgccccgccgtgctcaagcggcacggggtacaggagtgcatcctgctggtgactcagcgcatcaccaagtacccgttactcatcagccgcatcctgcagcattcccacgggatcgaggaggagcgccaggacctgaccacagcactggggctagtgaaggagctgctgtccaatgtggacgagggtatttatcagctggagaaaggggcccgtctgcaggagatctacaaccgcatggaccctcgggcccaaaccccagtgcctggcaagggcccctttggccgagaggaacttctgaggcgcaaactcatccacgatggctgcctgctctggaagacagcgacggggcgcttcaaagatgtgctagtgctgctgatgacagatgtactggtgtttctccaggaaaaggaccagaagtacatctttcctaccctggacaagccttcagtggtatcgctgcagaatctaatcgtacgagacattgccaaccaggagaaagggatgtttctgatcagcgcagccccacctgagatgtacgaggtgcacacagcatcccgggatgaccggagcacctggatccgggtcattcagcagagcgtgcgcacatgcccatccagggaggacttccccctgattgagacagaggatgaggcttacctgcggcgaattaagatggagttgcagcagaaggaccgggcactggtggagctgctgcgagagaaggtcgggctgtttgctgagatgacccatttccaggccgaagaggatggtggcagtgggatggccctgcccaccctgcccaggggccttttccgctctgagtcccttgagtcccctcgtggcgagcggctgctgcaggatgccatccgtgaggtggagggtctgaaagacctgctggtggggccaggagtggaactgctcttgacaccccgagagccagccctgcccttggaaccagacagcggtggtaacacgagtcctggggtcactgccaatggtgaggccagaaccttcaatggctccattgaactctgcagagctgactcagactctagccagagggatcgaaatggaaatcagctgagatcaccgcaagaggaggcgttacagcgattggtcaatctctatggacttctacatggcctacaggcagctgtggcccagcaggacactctgatggaagcccggttccctgagggccctgagcggcgggagaagctgtgccgagccaactctcgggatggggaggctggcagggctggggctgcccctgtggcccctgaaaagcaggccacggaactggcattactgcagcggcaacatgcgctgctgcaggaggagctacggcgctgccggcggctaggtgaagaacgggcaaccgaagctggcagcctggaggcccggctccgggagagtgagcaggcccgggcactgctggagcgtgaggccgaagaggctcgaaggcagctggccgccctgggccagaccgagccactcccagctgaggccccctgggcccgcagacctgtggatcctcggcggcgcagcctccccgcaggcgatgccctgtacttgagtttcaaccccccacagcccagccgaggcactgaccgcctggatctacctgtcactactcgctctgtccatcgaaactttgaggaccgagagaggcaggaactggggagccccgaagagcggctgcaagacagcagtgaccctgacactggcagcgaggaggaaggtagcagccgtctgtctccgccccacagtccacgagactttaccagaatgcaggacatcccggaggagacggagagccgcgacggggaggctgtagcctccgagagctaa
Sequence Length
2880
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
108,242 Da
NCBI Official Full Name
Homo sapiens rho/rac guanine nucleotide exchange factor (GEF) 2, mRNA
NCBI Official Synonym Full Names
Rho/Rac guanine nucleotide exchange factor 2
NCBI Official Symbol
ARHGEF2
NCBI Official Synonym Symbols
GEF; P40; GEFH1; LFP40; GEF-H1
NCBI Protein Information
rho guanine nucleotide exchange factor 2
UniProt Protein Name
Rho guanine nucleotide exchange factor 2
Protein Family
UniProt Gene Name
ARHGEF2
UniProt Synonym Gene Names
KIAA0651; LFP40; GEF-H1
UniProt Entry Name
ARHG2_HUMAN
NCBI Description
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
Uniprot Description
ARHGEF2: a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. Mediates cross-talk between microtubules and the actin cytoskeleton. Contains a phorbol esters/diacylglycerol binding and PH domain.
Protein type: Motility/polarity/chemotaxis; GEFs, Rac/Rho; GEFs
Chromosomal Location of Human Ortholog: 1q21-q22
Cellular Component: cytoplasm; cytoskeleton; cytosol; focal adhesion; microtubule; protein complex; vesicle
Molecular Function: guanyl-nucleotide exchange factor activity; microtubule binding; protein binding; Rac GTPase binding; Rac guanyl-nucleotide exchange factor activity; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity; transcription factor binding
Biological Process: actin filament organization; activation of NF-kappaB transcription factor; cell morphogenesis; negative regulation of microtubule depolymerization; positive regulation of apoptosis; positive regulation of interleukin-6 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of cell proliferation; regulation of small GTPase mediated signal transduction
Research Articles on ARHGEF2
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Product Notes
The ARHGEF2 arhgef2 (Catalog #AAA1268877) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaaggaag ccaaggatgc ccgctatacc aatgggcacc tcttcaccac catttcagtt tcaggcatga ccatgtgcta tgcctgtaac aagagcatca cagccaagga agccctcatc tgcccaacct gcaatgtgac tatccacaac cgctgtaaag acaccctcgc caactgtacc aaggtcaagc agaagcaaca gaaagcggcc ctgctgaaga acaacaccgc cttgcagtcc gtttctcttc gaagtaagac aaccatccgg gagcggccaa gctcggccat ctacccctcc gacagcttcc ggcagtccct cctgggctcc cgccgtggcc gctcctcctt gtctttagcc aagagtgttt ctaccaccaa cattgctgga catttcaatg atgagtctcc cctggggctg cgccggatcc tctcacagtc cacagactcc ctcaacatgc ggaaccgaac cctatccgtg gaatccctca ttgacgaagc agaggtaatc tacagtgagc tgatgagtga ctttgagatg gatgagaagg actttgcagc tgactcttgg agtcttgctg tggacagcag cttcctgcag cagcataaaa aggaggtgat gaagcagcaa gatgtcatct atgagctaat ccagacagag ctgcaccatg tgaggacact gaagatcatg acccgcctct tccgcacggg gatgctggaa gagctacact tggagccagg agtggtccag ggcctgttcc cctgcgtgga cgagctcagt gacatccata cacgcttcct cagccagcta ttagaacgcc gacgccaggc cctgtgccct ggcagcaccc ggaactttgt catccatcgc ttgggtgatc tgctcatcag ccagttctca ggtcctagtg cggagcagat gtgtaagacc tactcggagt tctgcagccg ccacagcaag gccttaaagc tctataagga gctgtacgcc cgagacaaac gcttccagca attcatccgg aaagtgaccc gccccgccgt gctcaagcgg cacggggtac aggagtgcat cctgctggtg actcagcgca tcaccaagta cccgttactc atcagccgca tcctgcagca ttcccacggg atcgaggagg agcgccagga cctgaccaca gcactggggc tagtgaagga gctgctgtcc aatgtggacg agggtattta tcagctggag aaaggggccc gtctgcagga gatctacaac cgcatggacc ctcgggccca aaccccagtg cctggcaagg gcccctttgg ccgagaggaa cttctgaggc gcaaactcat ccacgatggc tgcctgctct ggaagacagc gacggggcgc ttcaaagatg tgctagtgct gctgatgaca gatgtactgg tgtttctcca ggaaaaggac cagaagtaca tctttcctac cctggacaag ccttcagtgg tatcgctgca gaatctaatc gtacgagaca ttgccaacca ggagaaaggg atgtttctga tcagcgcagc cccacctgag atgtacgagg tgcacacagc atcccgggat gaccggagca cctggatccg ggtcattcag cagagcgtgc gcacatgccc atccagggag gacttccccc tgattgagac agaggatgag gcttacctgc ggcgaattaa gatggagttg cagcagaagg accgggcact ggtggagctg ctgcgagaga aggtcgggct gtttgctgag atgacccatt tccaggccga agaggatggt ggcagtggga tggccctgcc caccctgccc aggggccttt tccgctctga gtcccttgag tcccctcgtg gcgagcggct gctgcaggat gccatccgtg aggtggaggg tctgaaagac ctgctggtgg ggccaggagt ggaactgctc ttgacacccc gagagccagc cctgcccttg gaaccagaca gcggtggtaa cacgagtcct ggggtcactg ccaatggtga ggccagaacc ttcaatggct ccattgaact ctgcagagct gactcagact ctagccagag ggatcgaaat ggaaatcagc tgagatcacc gcaagaggag gcgttacagc gattggtcaa tctctatgga cttctacatg gcctacaggc agctgtggcc cagcaggaca ctctgatgga agcccggttc cctgagggcc ctgagcggcg ggagaagctg tgccgagcca actctcggga tggggaggct ggcagggctg gggctgcccc tgtggcccct gaaaagcagg ccacggaact ggcattactg cagcggcaac atgcgctgct gcaggaggag ctacggcgct gccggcggct aggtgaagaa cgggcaaccg aagctggcag cctggaggcc cggctccggg agagtgagca ggcccgggca ctgctggagc gtgaggccga agaggctcga aggcagctgg ccgccctggg ccagaccgag ccactcccag ctgaggcccc ctgggcccgc agacctgtgg atcctcggcg gcgcagcctc cccgcaggcg atgccctgta cttgagtttc aaccccccac agcccagccg aggcactgac cgcctggatc tacctgtcac tactcgctct gtccatcgaa actttgagga ccgagagagg caggaactgg ggagccccga agagcggctg caagacagca gtgaccctga cactggcagc gaggaggaag gtagcagccg tctgtctccg ccccacagtc cacgagactt taccagaatg caggacatcc cggaggagac ggagagccgc gacggggagg ctgtagcctc cgagagctaa. It is sometimes possible for the material contained within the vial of "ARHGEF2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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