ABCC11 cdna clone
ABCC11 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
ABCC11: Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Transporter; Transporter, ABC family; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 16q12.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: anion transmembrane-transporting ATPase activity; organic anion transmembrane transporter activity; purine nucleotide transmembrane transporter activity
Biological Process: organic anion transport; purine nucleotide transport; transmembrane transport
Disease: Apocrine Gland Secretion, Variation In
Research Articles on ABCC11
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Product Notes
The ABCC11 abcc11 (Catalog #AAA1268541) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgactagga agaggacata ctgggtgccc aactcttctg gtggcctcgt gaatcgtggc atcgacatag gcgatgacat ggtttcagga cttatttata aaacctatac tctccaagat ggcccctgga gtcagcaaga gagaaatcct gaggctccag ggagggcagc tgtcccaccg tgggggaagt atgatgctgc cttgagaacc atgattccct tccgtcccaa gccgaggttt cctgcccccc agcccctgga caatgctggc ctgttctcct acctcaccgt gtcatggctc accccgctca tgatccaaag cttacggagt cgcttagatg agaacaccat ccctccactg tcagtccatg atgcctcaga caaaaatgtc caaaggcttc accgcctttg ggaagaagaa gtctcaaggc gagggattga aaaagcttca gtgcttctgg tgatgctgag gttccagaga acaaggttga ttttcgatgc acttctgggc atctgcttct gcattgccag tgtactcggg ccaatattga ttataccaaa gatcctggaa tattcagaag agcagttggg gaatgttgtc catggagtgg gactctgctt tgcccttttt ctctccgaat gtgtgaagtc tctgagtttc tcctccagtt ggatcatcaa ccaacgcaca gccatcaggt tccgagcagc tgtttcctcc tttgcctttg agaagctcat ccaatttaag tctgtaatac acatcacctc aggagaggcc atcagcttct tcaccggtga tgtaaactac ctgtttgaag gggtgtgcta tggaccccta gtactgatca cctgcgcatc gctggtcatc tgcagcattt cttcctactt cattattgga tacactgcat ttattgccat cttatgctat ctcctggttt tcccactggc ggtattcatg acaagaatgg ctgtgaaggc tcagcatcac acatctgagg tcagcgacca gcgcatccgt gtgaccagtg aagttctcac ttgcattaag ctgattaaaa tgtacacatg ggagaaacca tttgcaaaaa tcattgaaga cctaagaagg aaggaaagga aactattgga gaagtgcggg cttgtccaga gcctgacaag tataaccttg ttcatcatcc ccacagtggc cacagcggtc tgggttctca tccacacatc cttaaagctg aaactcacag cgtcaatggc cttcagcatg ctggcctcct tgaatctcct tcggctgtca gtgttctttg tgcctattgc agtcaaaggt ctcacgaatt ccaagtctgc agtgatgagg ttcaagaagt ttttcctcca ggagagccct gttttctatg tccagacatt acaagacccc agcaaagctc tggtctttga ggaggccacc ttgtcatggc aacagacctg tcccgggatc gtcaatgggg cactggagct ggagaggaac gggcatgctt ctgaggggat gaccaggcct agagatgccc tcgggccaga ggaagaaggg aacagcctgg gcccagagtt gcacaagatc aacctggtgg tgtccaaggt agccttgttc aggccacgca ggcaggccag ctgccaggct ctcaggacct ga. It is sometimes possible for the material contained within the vial of "ABCC11, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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