PDGFRB cdna clone
PDGFRB cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]
Uniprot Description
PDGFRB: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation, thereby recruiting SH2-containing proteins including Grb2, Src, GAP, PTPN11, PI3 kinase, PLC-gamma and Nck. Regulates cell growth, actin reorganization, migration and differentiation. A variety of myeloproliferative disorders and cancers result from translocations that activate PDGFRbeta by fusion with proteins such as TEL/ETV6, H2, CEV14/TRP11, rabaptin 5, and huntington interacting protein 1. Gleevec treatment of TEL fusions has been successful. Overexpressed in metastatic medulloblastoma. Inhibitors: Gleevec, Sutent.
Protein type: Membrane protein, integral; EC 2.7.10.1; Oncoprotein; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; PDGFR family
Chromosomal Location of Human Ortholog: 5q33.1
Cellular Component: apical plasma membrane; cytoplasm; focal adhesion; intrinsic to plasma membrane; membrane; nucleus; plasma membrane
Molecular Function: phosphatidylinositol-4,5-bisphosphate 3-kinase activity; platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor activity; platelet-derived growth factor receptor binding; protein binding; protein kinase binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding
Biological Process: cardiac myofibril assembly; cell migration; MAPKKK cascade; peptidyl-tyrosine phosphorylation; phosphatidylinositol metabolic process; phosphoinositide-mediated signaling; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of MAP kinase activity; positive regulation of mitosis; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of phosphoprotein phosphatase activity; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; protein amino acid autophosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of phosphoinositide 3-kinase cascade; signal transduction
Disease: Basal Ganglia Calcification, Idiopathic, 1; Basal Ganglia Calcification, Idiopathic, 4; Kosaki Overgrowth Syndrome; Myeloproliferative Disorder, Chronic, With Eosinophilia; Myofibromatosis, Infantile, 1; Premature Aging Syndrome, Penttinen Type
Research Articles on PDGFRB
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Product Notes
The PDGFRB pdgfrb (Catalog #AAA1267952) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcggcttc cgggtgcgat gccagctctg gccctcaaag gcgagctgct gttgctgtct ctcctgttac ttctggaacc acagatctct cagggcctgg tcgtcacacc cccggggcca gagcttgtcc tcaatgtctc cagcaccttc gttctgacct gctcgggttc agctccggtg gtgtgggaac ggatgtccca ggagccccca caggaaatgg ccaaggccca ggatggcacc ttctccagcg tgctcacact gaccaacctc actgggctag acacgggaga atacttttgc acccacaatg actcccgtgg actggagacc gatgagcgga aacggctcta catctttgtg ccagatccca ccgtgggctt cctccctaat gatgccgagg aactattcat ctttctcacg gaaataactg agatcaccat tccatgccga gtaacagacc cacagctggt ggtgacactg cacgagaaga aaggggacgt tgcactgcct gtcccctatg atcaccaacg tggctttttt ggtatctttg aggacagaag ctacatctgc aaaaccacca ttggggacag ggaggtggat tctgatgcct actatgtcta cagactccag gtgtcatcca tcaacgtctc tgtgaacgca gtgcagactg tggtccgcca gggtgagaac atcaccctca tgtgcattgt gatcgggaat gaggtggtca acttcgagtg gacatacccc cgcaaagaaa gtgggcggct ggtggagccg gtgactgact tcctcttgga tatgccttac cacatccgct ccatcctgca catccccagt gccgagttag aagactcggg gacctacacc tgcaatgtga cggagagtgt gaatgaccat caggatgaaa aggccatcaa catcaccgtg gttgagagcg gctacgtgcg gctcctggga gaggtgggca cactacaatt tgctgagctg catcggagcc ggacactgca ggtagtgttc gaggcctacc caccgcccac tgtcctgtgg ttcaaagaca accgcaccct gggcgactcc agcgctggcg aaatcgccct gtccacgcgc aacgtgtcgg agacccggta tgtgtcagag ctgacactgg ttcgcgtgaa ggtggcagag gctggccact acaccatgcg ggccttccat gaggatgctg aggtccagct ctccttccag ctacagatca atgtccctgt ccgagtgctg gagctaagtg agagccaccc tgacagtggg gaacagacag tccgctgtcg tggccggggc atgccccagc cgaacatcat ctggtctgcc tgcagagacc tcaaaaggtg tccacgtgag ctgccgccca cgctgctggg gaacagttcc gaagaggaga gccagctgga gactaacgtg acgtactggg aggaggagca ggagtttgag gtggtgagca cactgcgtct gcagcacgtg gatcggccac tgtcggtgcg ctgcacgctg cgcaacgctg tgggccagga cacgcaggag gtcatcgtgg tgccacactc cttgcccttt aaggtggtgg tgatctcagc catcctggcc ctggtggtgc tcaccatcat ctcccttatc atcctcatca tgctttggca gaagaagcca cgttacgaga tccgatggaa ggtgattgag tctgtgagct ctgacggcca tgagtacatc tacgtggacc ccatgcagct gccctatgac tccacgtggg agctgccgcg ggaccagctt gtgctgggac gcaccctcgg ctctggggcc tttgggcagg tggtggaggc cacggctcat ggcctgagcc attctcaggc cacgatgaaa gtggccgtca agatgcttaa atccacagcc cgcagcagtg agaagcaagc ccttatgtcg gagctgaaga tcatgagtca ccttgggccc cacctgaacg tggtcaacct gttgggggcc tgcaccaaag gaggacccat ctatatcatc actgagtact gccgctacgg agacctggtg gactacctgc accgcaacaa acacaccttc ctgcagcacc actccgacaa gcgccgcccg cccagcgcgg agctctacag caatgctctg cccgttgggc tccccctgcc cagccatgtg tccttgaccg gggagagcga cggtggctac atggacatga gcaaggacga gtcggtggac tatgtgccca tgctggacat gaaaggagac gtcaaatatg cagacatcga gtcctccaac tacatggccc cttacgataa ctacgttccc tctgcccctg agaggacctg ccgagcaact ttgatcaacg agtctccagt gctaagctac atggacctcg tgggcttcag ctaccaggtg gccaatggca tggagtttct ggcctccaag aactgcgtcc acagagacct ggcggctagg aacgtgctca tctgtgaagg caagctggtc aagatctgtg actttggcct ggctcgagac atcatgcggg actcgaatta catctccaaa ggcagcacct ttttgccttt aaagtggatg gctccggaga gcatcttcaa cagcctctac accaccctga gcgacgtgtg gtccttcggg atcctgctct gggagatctt caccttgggt ggcacccctt acccagagct gcccatgaac gagcagttct acaatgccat caaacggggt taccgcatgg cccagcctgc ccatgcctcc gacgagatct atgagatcat gcagaagtgc tgggaagaga agtttgagat tcggcccccc ttctcccagc tggtgctgct tctcgagaga ctgttgggcg aaggttacaa aaagaagtac cagcaggtgg atgaggagtt tctgaggagt gaccacccag ccatccttcg gtcccaggcc cgcttgcctg ggttccatgg cctccgatct cccctggaca ccagctccgt cctctatact gccgtgcagc ccaatgaggg tgacaacgac tatatcatcc ccctgcctga ccccaaaccc gaggttgctg acgagggccc actggagggt tcccccagcc tagccagctc caccctgaat gaagtcaaca cctcctcaac catctcctgt gacagccccc tggagcccca ggacgaacca gagccagagc cccagcttga gctccaggtg gagccggagc cagagctgga acagttgccg gattcggggt gccctgcgcc tcgggcggaa gcagaggata gcttcctgta g. It is sometimes possible for the material contained within the vial of "PDGFRB, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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