DMRT1 cdna clone
DMRT1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]
Uniprot Description
DMRT1: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis. Defects in DMRT1 may be a cause of testicular germ cell tumor (TGCT). A common solid malignancy in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms. Defects in DMRT1 may be a cause of 46,XY sex reversal type 4 (SRXY4). A condition characterized by male-to- female sex reversal in the presence of a normal 46,XY karyotype. Patients display complete or partial gonadal dysgenesis and a chromosome 9p deletion. Belongs to the DMRT family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 9p24.3
Cellular Component: nucleus
Molecular Function: protein homodimerization activity; transcription factor activity
Biological Process: male sex determination; male sex differentiation; negative regulation of meiosis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mitosis; positive regulation of transcription from RNA polymerase II promoter; Sertoli cell differentiation; sex differentiation
Research Articles on DMRT1
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Product Notes
The DMRT1 dmrt1 (Catalog #AAA1267692) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcccaacg acgaggcatt cagcaagccc tctacaccgt cggaagcccc tcacgccccc ggggtaccgc cgcagggcag agccgggggc tttggcaaag cgtctggggc gctagtgggg gcggccagcg gctcgagcgc cgggggcagc agcagaggag gcggctccgg ctccggggcg tcggacctgg gtgccgggag caagaagtcc ccgcggctgc ccaagtgcgc acgctgcagg aaccacggct acgcctcgcc gctcaagggc cacaagcgct tctgcatgtg gcgcgactgc cagtgcaaga agtgcaacct gatcgccgag aggcagcgcg tgatggccgc gcaggtggcc ctgagaaggc agcaggccca ggaggaggaa ttgggtatca gccaccccat cccactgccc agtgcggccg agctgcttgt caaaagagag aacaatggca gtaacccgtg cctcatgact gagtgcagtg gcacctctca gccaccgccg gccagtgtcc ccaccactgc agcttcagag ggacgtatgg tcatccagga tattcctgct gtcaccagca gagggcatgt ggagaacaca cctgacctgg tttcagactc cacctactac agcagcttct accagccgtc tctgtttcct tattacaaca atctatacaa ctgcccgcag tactccatgg ccttggctgc tgattctgct tctggggagg tgggaaatcc cctcggggga tcccctgtga agaacagcct tcggggcctc cccggacctt atgtgcctgg tcagacagga aaccagtggc agatgaagaa catggagaac cgccatgcaa tgagctccca gtacaggatg cattcttact acccgcctcc ctcttacctg ggccagagcg tgccccagtt cttcactttt gaggatgctc cctcttaccc ggaagccagg gcgagcgtat tctcgccgcc cagcagtcaa gattctggct tggtttccct ctcgagcagc tctcctatta gtaacaagag cacaaaggca gtgcttgaat gtgagcctgc gtcggagccc agcagcttca cagtcactcc cgtcatcgag gaggacgagt ga. It is sometimes possible for the material contained within the vial of "DMRT1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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