NCK1 cdna clone
NCK1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
Uniprot Description
NCK1: adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 3q21
Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; endoplasmic reticulum; plasma membrane; protein phosphatase type 1 complex; ribosome; trans-Golgi network
Molecular Function: ARF guanyl-nucleotide exchange factor activity; protein binding; protein binding, bridging; protein kinase inhibitor activity; receptor binding; receptor tyrosine kinase binding
Biological Process: negative regulation of peptidyl-serine phosphorylation; positive regulation of actin filament polymerization; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; T cell activation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; vesicle-mediated transport
Research Articles on NCK1
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Product Notes
The NCK1 nck1 (Catalog #AAA1266491) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcagaag aagtggtggt agtagccaaa tttgattatg tggcccaaca agaacaagag ttggacatca agaagaatga gagattatgg cttctggatg attctaagtc ctggtggcga gttcgaaatt ccatgaataa aacaggtttt gtgccttcta actatgtgga aaggaaaaac agtgctcgga aagcatctat tgtgaaaaac ctaaaggata ccttaggcat tggaaaagtg aaaagaaaac ctagtgtgcc agattctgca tctcctgctg atgatagttt tgttgaccca ggggaacgtc tctatgacct caacatgccc gcttatgtga aatttaacta catggctgag agagaggatg aattatcatt gataaagggg acaaaggtga tcgtcatgga gaaatgcagt gatgggtggt ggcgtggtag ctacaatgga caagttggat ggttcccttc aaactatgta actgaagaag gtgacagtcc tttgggtgac catgtgggtt ctctgtcaga gaaattagca gcagtcgtca ataacctaaa tactgggcaa gtgttgcatg tggtacaggc tctttaccca ttcagctcat ctaatgatga agaacttaat ttcgagaaag gagatgtaat ggatgttatt gaaaaacctg aaaatgaccc agagtggtgg aaatgcagga agatcaatgg tatggttggt ctagtaccaa aaaactatgt taccgttatg cagaataatc cattaacttc aggtttggaa ccatcacctc cacagtgtga ttacattagg ccttcactca ctggaaagtt tgctggcaat ccttggtatt atggcaaagt caccaggcat caagcagaaa tggcattaaa tgaaagagga catgaagggg atttcctcat tcgtgatagt gaatcttcgc caaatgattt ctcagtatca ctaaaagcac aagggaaaaa caagcatttt aaagtccaac taaaagagac tgtctactgc attgggcagc gtaaattcag caccatggaa gaacttgtag aacattacaa aaaggcacca atttttacaa gtgaacaagg agaaaaatta tatcttgtca agcatttatc atga. It is sometimes possible for the material contained within the vial of "NCK1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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