RAD18 cdna clone
RAD18 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
Uniprot Description
RAD18: a structural maintenance of chromosomes (SMC) protein involved in postreplication repair of UV-damaged DNA. Has ssDNA binding activity. Interacts with Rad6 through a conserved ring-finger motif. Rad6 is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA.
Protein type: EC 6.3.2.19; DNA repair, damage; EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: centrosome; nuclear inclusion body; nucleoplasm; nucleus; replication fork
Molecular Function: identical protein binding; polyubiquitin binding; protein binding; protein complex binding; single-stranded DNA-dependent ATPase activity; ubiquitin protein ligase binding; Y-form DNA binding
Biological Process: DNA damage response, detection of DNA damage; positive regulation of chromosome segregation; postreplication repair; protein autoubiquitination; protein monoubiquitination; response to DNA damage stimulus; response to UV
Research Articles on RAD18
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Product Notes
The RAD18 rad18 (Catalog #AAA1266436) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggactccc tggccgagtc tcggtggcct ccgggcctgg cagtcatgaa gacaatagat gatttgctgc ggtgtggaat ttgcttcgag tatttcaaca ttgcaatgat aatacctcag tgttcacata actactgctc tctctgtata agaaaatttc tgtcctataa aactcagtgt ccaacttgct gtgtgactgt cacagagccg gatctgaaaa ataaccgcat attagatgaa ctggtaaaaa gcttgaattt tgcacggaat catctgctgc agtttgcttt agagtcacca gccaaatctc ctgcttcttc ctcttcaaag aatcttgctg tcaaagtata tactcctgta gcctccagac agtctttaaa gcaggggagc aggttaatgg ataatttctt gatcagagaa atgagtggtt ctacatcaga gttgttgata aaagaaaata aaagcaaatt cagccctcaa aaagaggcga gccctgctgc aaagaccaaa gagacacgtt ctgtagaaga gatcgctcca gatccctcag aggctaagcg tcctgagcca ccctcgacat ccactttgaa acaagttact aaagtggatt gtcctgtttg cggggttaac attccagaaa gtcacattaa taagcattta gacagctgtt tatcacgcga agagaagaag gaaagcctca gaagttctgt tcacaaaagg aagccgctgc ccaaaactgt atataatttg ctctctgatc gtgatttaaa gaaaaagcta aaagagcatg gattatctat tcaaggaaat aaacaacagc tcattaaaag gcaccaagaa tttgtacaca tgtacaatgc ccaatgcgat gctttgcatc ctaaatcagc tgctgaaata gttcaagaaa tcgaaaatat agagaagact aggatgcgtc ttgaagctag taaactcaat gaaagtgtaa tggtttttac aaaggaccaa acagaaaagg aaatagatga aatccacagt aaatatcgta aaaaacataa gagtgaattt cagcttctgg tggatcaggc tagaaaagga tacaagaaaa ttgctggaat gtcacaaaaa acagtaacaa taacaaaaga agatgaatct acagaaaagc tatcttctgt atgcatggga caggaagata atatgacctc agtaacaaac cacttttctc aatcaaagct ggactcccca gaggaattgg aacctgacag agaagaggat tcttctagct gtattgatat tcaagaagtt ctttcttcat cagaatcaga ttcatgcaat agttccagtt cagacatcat aagagatctt ttagaagaag aggaagcctg ggaagcatca cataaaaacg atcttcaaga cacagaaata agtccaagac agaatcgccg cacaagagcc gctgaaagtg ctgagattga accaagaaac aagcgtaata ggaattaa. It is sometimes possible for the material contained within the vial of "RAD18, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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