Platelet-activating factor acetylhydrolase IB subunit alpha (PAFAH1B1) Recombinant Protein | PAFAH1B1 recombinant protein

Recombinant Cat Platelet-activating factor acetylhydrolase IB subunit alpha (PAFAH1B1)

Cat. Num. AAA1261805

• Gene Names: PAFAH1B1; LIS1; LIS-1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Platelet-activating factor acetylhydrolase IB subunit alpha (PAFAH1B1); Recombinant Cat Platelet-activating factor acetylhydrolase IB subunit alpha (PAFAH1B1); PAFAH1B1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-410, Full length protein
• Sequence: MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR
• Sequence Length: 410

• Species: Felis catus (Cat) (Felis silvestris catus)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for PAFAH1B1 recombinant protein

This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.

NCBI and Uniprot Product Information

• NCBI GI #: 167234378
• NCBI GeneID: 100135766
• NCBI Accession #: NP_001107812.1
• NCBI GenBank Nucleotide #: NM_001114340.1
• UniProt Accession #: B0LSW3
• Molecular Weight: 46,670 Da
• NCBI Official Full Name: platelet-activating factor acetylhydrolase IB subunit alpha
• NCBI Official Symbol: PAFAH1B1
• NCBI Official Synonym Symbols: LIS1; LIS-1
• NCBI Protein Information: platelet-activating factor acetylhydrolase IB subunit alpha
• UniProt Protein Name: Platelet-activating factor acetylhydrolase IB subunit alpha
• Protein Family: Platelet-activating factor acetylhydrolase
• UniProt Gene Name: PAFAH1B1
• UniProt Synonym Gene Names: LIS-1; PAF-AH 45 kDa subunit; PAFAH alpha

Uniprot Description

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos.