Frizzled-1 (FZD1) Recombinant Protein | FZD1 recombinant protein
Recombinant Chicken Frizzled-1 (FZD1)
NCBI and Uniprot Product Information
Uniprot Description
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
By similarity.
Tissue specificity: Expressed in the lens, otic placode (medial wall of the vesicle) and in epibranchial placode. Also expressed in the developing somites (dermomyotome).
Developmental stage: Somites and placodal expression appears at stage 9. At this stage, more obvious expression is detected in the neural tube (midbrain and rostral hindbrain), and persists through about stage 15. Strongly expressed in the ectoderm and around the otic placodes at stage 12. At stage 16, otic expression declines, expression in epibranchial placodes begins and peaks at stage 20. Expression in the lens of the eye is first seen at about stage 15, more evident at stage 16. At stage 17, seen in the ectoderm and mesenchyme of the limb primordia. Detected at stage 20 in the lip of the optic cup, in the mesenchyme surrounding the eye, in the ectoderm overlying the lens and in the ectoderm caudal and ventral of the olfactory placodes. From stages 20-30, expressed in cartilage and in the dermomyotomes and migrating sclerotomal cells forming vertebrae.
Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway
By similarity.The FZ domain is involved in binding with Wnt ligands
By similarity.
Sequence similarities: Belongs to the G-protein coupled receptor Fz/Smo family.Contains 1 FZ (frizzled) domain.
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Product Notes
The FZD1 fzd1 (Catalog #AAA1250514) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 49-592. The amino acid sequence is listed below: QPAAQPAALS ERGISIPDHG YCQPISIPLC TDIAYNQTIM PNLLGHTNQE DAGLEVHQFY PLVKVQCSAE LKFFLCSMYA PVCTVLEQAL PPCRSLCERA RQGCEALMNK FGFQWPDTLR CEKFPVHGAG ELCVGQNASE RGTPTPALRP ESWTSNPHRG GGAGGSGPGE ARGRFSCPRA LKVPSYLNYR FLGEKDCGAP CEPGRLYGLM YFGPEELRFS RTWIGIWSVL CCASTLFTVL TYLVDMKRFS YPERPIIFLS GCYTAVAVAY IAGFLLEERV VCNERFAEDG SRTVAQGTKR EGCTILFMML YFFGMASSIW WVILSLTWFL AAGMKWGHEA IEANSQYFHL AAWAVPAIKT ITILALGQVD GDVLSGVCFV GINNVDALRG FVLAPLFVYL FIGTSFLLAG FVSLFRIRTI MKHDGTKTEK LEKLMVRIGI FSVLYTVPAT IVIACYFYEQ AFREQWERSW VTQSCKSYAI PCPNNHSSHH PPMSPDFTVF MIKYLMTLIV GITSGFWIWS GKTLNSWRKF YTRLTNSKQG ETTV. It is sometimes possible for the material contained within the vial of "Frizzled-1 (FZD1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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