Sensor protein CpxA (cpxA) Recombinant Protein | cpxA recombinant protein

Recombinant Escherichia coli Sensor protein CpxA (cpxA), partial

Cat. Num. AAA1239569

• Gene Names: cpxA; ecfB; ECK3904; eup; JW3882; rssE; ssd
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Sensor protein CpxA (cpxA); Recombinant Escherichia coli Sensor protein CpxA (cpxA); partial; cpxA recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-457
• Sequence: MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAPPGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVELVGPFSVRDGEDNYQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS
• Sequence Length: 457

• Species: Escherichia coli (strain K12)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 16131751
• NCBI GeneID: 948405
• NCBI Accession #: NP_418347.1
• NCBI GenBank Nucleotide #: NC_000913.3
• UniProt Accession #: P0AE82; P08336; Q2M8K8
• Molecular Weight: 51,624 Da
• NCBI Official Full Name: sensory histidine kinase in two-component regulatory system with CpxR
• NCBI Official Symbol: cpxA
• NCBI Official Synonym Symbols: ecfB; ECK3904; eup; JW3882; rssE; ssd
• NCBI Protein Information: sensory histidine kinase in two-component regulatory system with CpxR
• UniProt Protein Name: Sensor histidine kinase CpxA
• Protein Family: Sensor protein
• UniProt Gene Name: cpxA
• UniProt Synonym Gene Names: ecfB; eup; ssd

NCBI Description

The sensor protein CpxA is part of the two-component CpxA/CpxR signal transduction system. [More information is available at EcoCyc: EG10163].

Uniprot Description

Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA (PubMed:7883164, PubMed:9401031, PubMed:9473036). Activates CpxR by phosphorylation; has autokinase, phosphotransferase and (in the presence of Mg2+ and/or ATP or ADP) phosphatase activity (PubMed:9401031, PubMed:17259177, PubMed:24492262). The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition (PubMed:16166523, PubMed:17259177, PubMed:25207645). Involved in several diverse cellular processes, including the functioning of acetohydroxyacid synthetase I, the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid (PubMed:8432716), and the synthesis, translocation, or stability of cell envelope proteins (PubMed:7883164). Activates transcription of periplasmic protease degP, probably by phosphorylating the cognate response protein CpxR; overexpression of an outer membrane lipoprotein NlpE also leads to transcription of degP via CpxRA (PubMed:7883164). Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation (PubMed:11830644).