Frizzled-3 (fzd3) Recombinant Protein | fzd3 recombinant protein
Recombinant Xenopus laevis Frizzled-3 (fzd3)
NCBI and Uniprot Product Information
Uniprot Description
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt8.
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Probable.
Tissue specificity: Expression restricted to the early nervous system.
Developmental stage: Low expression from cleavage stages to the end of gastrulation; increases from neurulation onward. During neurulation, first localized to the anterior neural folds. As neurulation proceeds, the expression extends to the trunk neural fold, with low levels in the posterior neural fold. At the end of neurulation, strongly expressed as a large band in the midbrain. After neural tube closure, also detected in the optic lobes and otic vesicles. During the late development, expression remains restricted to the nervous system. Detected until at least the larval stages.
Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. Ref.2The FZ domain is involved in binding with Wnt ligands
By similarity. Ref.2
Sequence similarities: Belongs to the G-protein coupled receptor Fz/Smo family.Contains 1 FZ (frizzled) domain.
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Product Notes
The fzd3 fzd3 (Catalog #AAA1235372) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 17-664. The amino acid sequence is listed below: QKSMGHSLFA CEPITLRMCQ DLPYNSTFMP NLLNHYDQQT AALAMEPFHP MVNLECSRDL RPFLCALYTP VCMEYGRMTL PCRKLCQRAY NECFKLMEMF GVPWPEEMEC SRFPDCDEPY PRIVDISLSG EPSEETPLAV QRDYGFWCPR ELKIDPDLRS SFLGVRDCSP PCPHMYFRRE ELSFARYFIG VISIVCLSAT LFTFLTFLID VTRFRYPERP IIFYAVCYMM VSLIFFIGFL LEDKVACNGA NPSQYKASTV TQGSHNKACT MLFMVLYFFT MAGSVWWVIL TITWFLAAVP KWGSEAIEKK ALLFHASAWG IPGTLTIILL AMNKIEGDNI SGVCFVGLYD VHALRYFVLA PLCLDVVVGV SLLLAGIISL NRVRIEIPLE KENQDKLVKF MIRIGVFSIL YLVPLLVVIG CYFYEQAYRG VWETTWVQER CREYHIPCPY KVTQTSRPDL ILFLMKYLML LVVGIPSVFW VGSKKTCFEW ASFFHGRKKK AGVNESRQVL QEPDFAQSLL RDPNTPIVRK SRGTSTQGTS THASSTQLAM LDDQRSKAGS VQSKVSSYHG SLHRSRDGRY TPCSYRGIEE RLPHGSMSHL TDHSRHSSTH RLNEQSHQGS IRDLSNPLAH ISHGTSMNRV IEADATSA. It is sometimes possible for the material contained within the vial of "Frizzled-3 (fzd3), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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