Flap endonuclease 1 (rad2) Recombinant Protein | rad2 recombinant protein
Recombinant Schizosaccharomyces japonicus Flap endonuclease 1 (rad2)
NCBI and Uniprot Product Information
Uniprot Description
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
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Product Notes
The rad2 rad2 (Catalog #AAA1227173) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-377, Full length. The amino acid sequence is listed below: MGIKGLSQVI ADNCPSAVRH NDIKNYFGRK VAIDASMSLY QFLIQVRGQD GQQLMNDQGE TTSHLMGMFY RTLRMVDNGL KPCYVFDGKP PTLKSGELAK RASRQQKARE EREEAKEVGT AEMVDKFAKR TVRVTRQHND EAKKLLELMG IPYVNAPCEA EAQCAALARA GKVYAAASED MDTMCFQAPI LLRHLTFSEQ RKEPISEYSF EKTIEGLNFT IEQFVDLCIL LGCDYCDPIR GVGPARAVEL IRQHGNLDNF VKDADKKKFP IPEDWPYQDA RRLFLEAEVQ EAKDIELKWR APDEQGIIKF LVEEKGFNED RVRVGINRLV KASKTIPQGR LDSFFKVLPS TKKEKEKPKA AAKRKRDTKS SAPKKKR. It is sometimes possible for the material contained within the vial of "Flap endonuclease 1 (rad2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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