3 beta-hydroxysteroid dehydrogenase type 7 (Hsd3b7) Recombinant Protein | Hsd3b7 recombinant protein

Recombinant Rat 3 beta-hydroxysteroid dehydrogenase type 7 (Hsd3b7)

• Gene Names: Hsd3b7; Cca2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: 3 beta-hydroxysteroid dehydrogenase type 7 (Hsd3b7); Recombinant Rat 3 beta-hydroxysteroid dehydrogenase type 7 (Hsd3b7); Recombinant 3 beta-hydroxysteroid dehydrogenase type 7 (Hsd3b7); 3 beta-hydroxysteroid dehydrogenase type 7; 3 beta-hydroxysteroid dehydrogenase type VII; 3-beta-HSD VII 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; C(27) 3-beta-HSD EC= 1.1.1.- Chol; Hsd3b7 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-338
• Sequence: MADSAQVPALVYLVTGGCGFLGEHIVRMLLEWEPRLRELRVFDLHLSSWLEELKTGPVQVTAIQGDVTQAHEVAAAMAGSHVVIHTAGLVDVFGKASPETIHKVNVQGTQNVIDACVQTGTRLLVYTSSMEVVGPNVKGHPFYRGNEDTPYEAIHRHPYPCSKALAEQLVLEANGRKGLRFGGRLFRAIPASVEHGRVYVGNVAWMHILVARELEQRAALMGGQVYFCYDKSPYKSYEDFNMEFLSPCGLRLIGTHPLLPYWLLVLLTALNALLQWLLRPLVLYTPLLNPYTLAVANTTFTVSTNKAQRHFGYKPLFSWEESRARTIHWVQAMEGSAW
• Sequence Length: 338

• Species: Rattus norvegicus (Rat)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 21326449
• NCBI GeneID: 246211
• NCBI Accession #: NP_647545.1
• NCBI GenBank Nucleotide #: NM_139329.1
• UniProt Accession #: O35048
• Molecular Weight: 37,781 Da
• NCBI Official Full Name: 3 beta-hydroxysteroid dehydrogenase type 7
• NCBI Official Synonym Full Names: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
• NCBI Official Symbol: Hsd3b7
• NCBI Official Synonym Symbols: Cca2
• NCBI Protein Information: 3 beta-hydroxysteroid dehydrogenase type 7; 3-beta-HSD VII; c(27) 3-beta-HSD; confluent 3Y1 cell-associated 2; 3 beta-hydroxysteroid dehydrogenase type VII; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase
• UniProt Protein Name: 3 beta-hydroxysteroid dehydrogenase type 7
• Protein Family: 3 beta-hydroxysteroid dehydrogenase
• UniProt Gene Name: Hsd3b7
• UniProt Synonym Gene Names: 3-beta-HSD VII; C(27) 3-beta-HSD
• UniProt Entry Name: 3BHS7_RAT

NCBI Description

protein that is expressed in under growth-arrest conditions [RGD, Feb 2006]

Uniprot Description

HSD3B7: The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Defects in HSD3B7 are the cause of congenital bile acid synthesis defect type 1 (CBAS1); also known as neonatal progressive intrahepatic cholestasis. CBAS1 is due to a primary defect in bile synthesis leading to progressive liver disease. Clinical features include neonatal jaundice, severe intrahepatic cholestasis and cirrhosis. Belongs to the 3-beta-HSD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - primary bile acid biosynthesis; Membrane protein, multi-pass; Membrane protein, integral; EC 1.1.1.181; Oxidoreductase

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; integral to membrane

Molecular Function: cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity; 3-beta-hydroxy-delta5-steroid dehydrogenase activity; isomerase activity

Biological Process: bile acid metabolic process; regulation of cell growth; steroid biosynthetic process