Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (Nos1ap) Recombinant Protein | Nos1ap recombinant protein

Recombinant Rat Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (Nos1ap)

Cat. Num. AAA1217352

• Gene Names: Nos1ap; Capon
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (Nos1ap); Recombinant Rat Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (Nos1ap); Nos1ap recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-503, Full length protein
• Sequence: MPSKTKYNLVDDGHDLRIPLHNEDAFQHGISFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSDGSGDPGRQLTGAERVSTATAEETDIDAVEVPLPGNDILEFSRGVTDLDAIGKDGGSHIDTTVSPHPQEPMLAASPRMLLPSSSSSKPPGLGTGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQSTMGSQDSLLEITFRSGALPVLCESTTPKPEDLHSPLLGAGLADFAHPVGSPLGRRDCLVKLECFRFLPAEDNQPMAQGEPLLGGLELIKFRESGIASEYESNTDESEERDSWSQEELPRLLNVLQRQELGDSLDDEIAV
• Sequence Length: 503

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Nos1ap recombinant protein

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 20302133
• NCBI GeneID: 192363
• NCBI Accession #: NP_620277.1
• NCBI GenBank Nucleotide #: NM_138922.1
• UniProt Accession #: O54960
• Molecular Weight: 55,864 Da
• NCBI Official Full Name: carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
• NCBI Official Synonym Full Names: nitric oxide synthase 1 adaptor protein
• NCBI Official Symbol: Nos1ap
• NCBI Official Synonym Symbols: Capon
• NCBI Protein Information: carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
• UniProt Protein Name: Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
• Protein Family: Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
• UniProt Gene Name: Nos1ap
• UniProt Synonym Gene Names: Capon

NCBI Description

involved in regulating the interaction between neuronal nitric oxide synthase and PSD95 [RGD, Feb 2006]

Uniprot Description

Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4.