Telomere length regulator protein RIF1 (RIF1) Recombinant Protein | RIF1 recombinant protein

Recombinant Saccharomyces cerevisiae Telomere length regulator protein RIF1 (RIF1) , partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Telomere length regulator protein RIF1 (RIF1); Recombinant Saccharomyces cerevisiae Telomere length regulator protein RIF1 (RIF1); partial; RIF1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,916

• Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 398365841
• NCBI GeneID: 852578
• NCBI Accession #: NP_009834.4
• NCBI GenBank Nucleotide #: NM_001178623.4
• UniProt Accession #: P29539; P89507; D6VQS1
• Molecular Weight: 217,931 Da
• NCBI Official Full Name: DNA-binding protein RIF1
• NCBI Official Symbol: RIF1
• NCBI Protein Information: DNA-binding protein RIF1
• UniProt Protein Name: Telomere length regulator protein RIF1
• Protein Family: Telomere-associated protein
• UniProt Gene Name: RIF1

Uniprot Description

Negatively regulates telomere length by preventing telomere elongation or promoting degradation of the telomere ends. Recruited to telomeres by interaction with the C-terminus of RAP1, which binds directly to telomeric repeat DNA. This may create a negative feedback loop in which the addition of new telomere repeats creates binding sites for inhibitors of telomere length extension. May also influence the balance of transcriptional silencing at telomeres and the silent mating type locus HMR, which is mediated by SIR (Silent Information Regulator) proteins including SIR3 and SIR4. RIF1 competes with SIR proteins for binding to the C-terminus of RAP1. In the absence of RIF1, a limiting cellular pool of SIR proteins may preferentially associate with RAP1 at sub-telomeric loci, causing enhanced telomeric silencing and attenuated silencing of the HMR locus.