Immediate early glycoprotein (UL37) Recombinant Protein | UL37 recombinant protein
Recombinant Human cytomegalovirus Immediate early glycoprotein (UL37)
NCBI and Uniprot Product Information
Uniprot Description
Function: Isoform vMIA sequesters proapoptotic BAX at the outer mitochondrial membrane and prevents cytochrome c release and subsequent initiation of the proapoptotic cascade. Also provoques a calcium efflux from host endoplasmic reticulum and F-actin cytoskeleton disruption. Participates in the increase of host mitochondrial biogenesis, thus promoting viral replication by efficient use of newly made mitochondria. Ref.6 Ref.7 Ref.11Isoform gpUL37 may play a role in escape from the host antiviral response. Ref.6 Ref.7 Ref.11
Subunit structure: Isofom vMIA interacts with host BAX. Isoform vMIA interacts with host RSAD2/viperin; this interaction results in RSAD2/viperin relocalization from the endoplasmic reticulum to the mitochondria, actin cytoskeleton disruption and enhancement of infection. Ref.6 Ref.10
Subcellular location: Isoform gpUL37: Host membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host mitochondrion membrane; Single-pass membrane protein. Note: The C-terminal fragment localizes to the endoplasmic reticulum while the N-terminal fragment is stable and traffics to mitochondria. Ref.5 Ref.8 Ref.9Isoform vMIA: Host mitochondrion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Note: Transported from the endoplasmic reticulum (ER) through the mitochondrial associated membrane (MAMs) to the mitochondrial outer membrane. Associates with internal lipid rafts (LRs) in the MAM. Ref.5 Ref.8 Ref.9Isoform pUL37m: Host mitochondrion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Note: Not cleaved or N-glycosylated. Ref.5 Ref.8 Ref.9
Sequence similarities: Belongs to the immediate early glycoprotein family.
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Product Notes
The Immediate early glycoprotein (UL37) ul37 (Catalog #AAA1202908) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 23-487. The amino acid sequence is listed below: RWIQRKRLED PLPPWLRKKK ACALTRRSRH RLRRQHGVID GENSETERSV DLVAALLAEA GEESVTEDTE REDTEEERED EEEENEARTP EVNPIDAEGL SGLAREACEA LKKALRRHRF LWQRRQRARM LQHNGPQQSH HAAVFCRVHG LRGFQVSVWL LLTLLWSTGH GVSVRCTYHG TDVNRTSNTT SMNCHLNCTR NHTQIYNGPC LGTEARLPLN VTFNQSRRKW HSVMLKFGFQ YHLEGWFPLR VLNESREINV TEVHGEVACF RNDTNVTVGQ LTLNFTGHSY VLRAIAHTSP FESYVRWEET NVTDNATSSE NTTTVMSTLT KYAESDYIFL QDMCPRFLKR TVKLTRNKTK HNVTVTGNNM TTLPVWTPEC KGWTYWTTLS VMWRNRRSAL LRAKSRALGH WALLSICTVA AGSIALLSLF CILLIGLRRD LLEDFRYICR DEGSSSTKND VHRIV. It is sometimes possible for the material contained within the vial of "Immediate early glycoprotein (UL37), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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