Envelope glycoprotein E (gE) Recombinant Protein | US8 recombinant protein
Recombinant Human herpesvirus 1 Envelope glycoprotein E (gE)
NCBI and Uniprot Product Information
Uniprot Description
Function: In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells
By similarity. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips. Ref.5 Ref.7The heterodimer gE/gI serves as a receptor for the Fc part of host IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-HSV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host IgG-mediated immune responses. Ref.5 Ref.7
Subunit structure: Interacts with gI; this interaction enhances the Fc receptor function of gE
By similarity. The heterodimer gE/gI interacts with the Fc part of host IgG. Interacts (via C-terminus) with VP22 tegument protein; this interaction is necessary for the recruitment of VP22 to the Golgi and its packaging into virions. Interacts (via C-terminus) with UL11 tegument protein. Ref.5 Ref.8 Ref.9 Ref.10
Subcellular location: Virion membrane; Single-pass type I membrane protein
By similarity. Host cell membrane; Single-pass type I membrane protein
By similarity. Host cell junction. Host Golgi apparatus membrane; Single-pass membrane protein
By similarity. Host endosome membrane; Single-pass membrane protein
By similarity. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein. The heterodimer gE/gI then redistributes to cell junctions to promote cell-cell spread later in the infection.
Post-translational modification: Phosphorylated on serines within the acidic cluster
Potential. Phosphorylation determines whether endocytosed viral gE traffics to the trans-Golgi network or recycles to the cell membrane
Potential. Ref.6N-glycosylated, and sulfated. Ref.4
Sequence similarities: Belongs to the alphaherpesvirinae glycoprotein E family.
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Product Notes
The US8 ge (Catalog #AAA1199302) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 21-550. The amino acid sequence is listed below: GTPKTSWRRV SVGEDVSLLP APGPTGRGPT QKLLWAVEPL DGCGPLHPSW VSLMPPKQVP ETVVDAACMR APVPLAMAYA PPAPSATGGL RTDFVWQERA AVVNRSLVIH GVRETDSGLY TLSVGDIKDP ARQVASVVLV VQPAPVPTPP PTPADYDEDD NDEGEDESLA GTPASGTPRL PPPPAPPRSW PSAPEVSHVR GVTVRMETPE AILFSPGETF STNVSIHAIA HDDQTYSMDV VWLRFDVPTS CAEMRIYESC LYHPQLPECL SPADAPCAAS TWTSRLAVRS YAGCSRTNPP PRCSAEAHME PVPGLAWQAA SVNLEFRDAS PQHSGLYLCV VYVNDHIHAW GHITISTAAQ YRNAVVEQPL PQRGADLAEP THPHVGAPPH APPTHGALRL GAVMGAALLL SALGLSVWAC MTCWRRRAWR AVKSRASGKG PTYIRVADSE LYADWSSDSE GERDQVPWLA PPERPDSPST NGSGFEILSP TAPSVYPRSD GHQSRRQLTT FGSGRPDRRY SQASDSSVFW. It is sometimes possible for the material contained within the vial of "Envelope glycoprotein E (gE), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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