Replicase polyprotein 1a (1a) Recombinant Protein | orf1ab recombinant protein
Recombinant Bovine coronavirus Replicase polyprotein 1a (1a), partial
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Replicase polyprotein 1a (1a); Recombinant Bovine coronavirus Replicase polyprotein 1a (1a); partial; orf1ab recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
4370-4383
Sequence
SKDTNFLNGFGVRV
Sequence Length
4383
Species
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
797,266 Da
NCBI Official Full Name
orf1a polyprotein
NCBI Official Symbol
orf1ab
NCBI Protein Information
orf1ab polyprotein; orf1a polyprotein; Leader protein; MHV p65-like protein; coronavirus nsp1 (PL1-PRO, PL2-PRO, HD); coronavirus nsp2 (3CL-PRO); coronavirus nsp3 (HD2); coronavirus nsp4; coronavirus nsp5; coronavirus nsp6; coronavirus nsp7 (GFL); RNA-dependent RNA polymerase; coronavirus nsp10 (MB, NTPase/HEL); coronavirus nsp11; coronavirus nsp12; coronavirus nsp13; transmembrane domain 2
UniProt Protein Name
Replicase polyprotein 1a
UniProt Gene Name
1a
UniProt Synonym Gene Names
pp1a; nsp1; nsp2; nsp3; nsp4; 3CL-PRO; 3CLp; nsp6; nsp7; nsp8; nsp9; nsp10; GFL; nsp11
Uniprot Description
The papain-like proteinase 1 (PL1-PRO) and papain-like proteinase 2 (PL2-PRO) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3 ().
Research Articles on orf1ab
1. nsp1 is an RNA-binding protein that may function as a regulator of viral translation or replication.
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Product Notes
The orf1ab 1a (Catalog #AAA1193922) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 4370-4383. The amino acid sequence is listed below: SKDTNFLNGF GVRV. It is sometimes possible for the material contained within the vial of "Replicase polyprotein 1a (1a), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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